This disease typically begins in the sigmoid colon and/or rectum, and then usually progresses until the entire colon is affected. Ulcerative colitis involves only the colonic mucosa, and the lesions are uniform and continuous with no areas of normal tissue interspersed between the diseased mucosa.
Both ulcerative colitis and Crohn's disease are chronic diseases that involve inflammation of the gastrointestinal tract. However, ulcerative colitis only affects the colon (large intestine), while Crohn's disease can affect the entire digestive system, from the mouth to the anus.
It is seen in both sexes equally, although white and Jewish people are more often affected. A person is five times more likely to get it if one parent has the condition. Peak occurrence is from 15-35 years of age, although any age is susceptible.
Ulcerative colitis primarily affects the colon and the rectum. About half of patients with ulcerative colitis have mild symptoms. Ulcerative colitis may also cause problems such as arthritis, inflammation of the eye, liver disease (fatty liver, hepatitis, cirrhosis, and primary sclerosing cholangitis), osteoporosis, skin rashes, anemia, and kidney stones. No one knows for sure why problems occur outside the colon. Scientists think these complications may occur when the immune system triggers inflammation in other parts of the body. These problems are usually mild and go away when the colitis is treated.
Systemic and extracolonic symptoms include: skin changes; liver disease; posterior uveitis, etc.; decreased growth and development; and failure to thrive (in children).
If the disease is limited to the rectosigmoidal area then stools may be normal or dry although there can also be constipation. Rectal mucous, which can be high in red and white blood cells, accompanies stools or occurs between bowel movements.
Ulcerative colitis may result in an increased urgency to defecate, up to 10 or 20 times per day.
In severe acute attacks there may be fever.
Because people with inflammatory bowel disease (IBD), like ulcerative colitis and Crohn's disease, have a much higher risk of both thromboses and osteoporosis, a team of researchers from McGill University in Montreal explored the idea that homocysteine excess may play an important role in this chronic gastrointestinal disease.
To test this hypothesis, they measured homocysteine levels in the plasma of 65 patients with IBD and in 127 healthy controls. Their results revealed a striking difference: The patients with IBD had nearly a six-fold increased incidence of hyperhomocysteinemia (homocysteine levels above the normal range) compared to controls.
About one in every seven patients in the IBD group had hyperhomocysteinemia. As expected, those with vitamin B12 deficiency tended to have higher homocysteine levels. Yet researchers were also surprised to find that 80% of the IBD patients with hyperhomocysteinemia had normal blood levels of vitamins.
This suggests that homocysteine imbalances could be an early warning sign of B-vitamin deficiency inside cells – one that occurs well before vitamin levels actually decline in serum. It is still too early to tell if treating high homocysteine could actually reduce IBD symptoms in patients.
Importantly, as homocysteine levels rose in the patients with IBD, so did the clinical ratings of IBD disease severity, including its length of duration and the use of steroid medications to treat it. [Am J Gastroenterol. 2001 96(7): pp.2143-9]
When the immune system triggers inflammation in other parts of the body because of ulcerative colitis, kidney stones may result. This influence is usually mild and stones may not be a problem once the colitis is treated.
Based on a study of 3,545 people who received live measles vaccine as children, their rate of developing ulcerative colitis was 2.5 times higher (3 times higher for Crohn's) compared to an unvaccinated group.
A variety of bacterial pathogens can cause severe gastrointestinal symptoms such as bloody diarrhea, fever or abdominal pain. In addition, many of these intestinal microbes can exacerbate or cause flare-ups of symptoms in patients who already have ulcerative colitis.
Crohn's disease affects men and women equally and seems to run in some families. About 20% of people with Crohn's disease have a blood relative with some form of IBD, most often a brother or sister and sometimes a parent or child. A person with one parent who had colitis is five times more likely to have the condition themselves.
Long term stress increases the risk of Ulcerative Colitis flare-ups, according to a study by Susan Levenstein, MD, at the Nuovo Regina Margherita Hospital in Rome. [American Journal of Gastroenterology, May 2000]
Slippery elm's soothing mucilage effect has been used for disorders of the gastrointestinal tract. It is part of the herbal combination called "Robert's Formula", which is widely prized by naturopathic physicians for such intestinal inflammations as gastritis, Crohn's disease and ulcerative colitis. For digestive disorders, taking 500-1,000mg of powder tid is often recommended. It may be used in lozenge form as well.
One small, controlled, double-blind trial has shown that boswellia extract may be helpful for ulcerative colitis. [Eur J Med Res 1997;2: pp.37-43]
Short fasts can be beneficial, giving the entire organism an opportunity to restore its cellular and immunogenic integrity.
A study found Plantago ovata seed (the whole psyllium seed, not just the husk) at 10gm bid to be as effective as the drug mesalamine for maintaining remission in patients with ulcerative colitis. In addition, the Plantago ovata seed may help prevent colon cancer, a common complication of ulcerative colitis, because it increases colonic butyrate levels.
It may be wise to avoid the food additive carrageenan, found in various foods such as apple cider, hot dogs, most ice creams and prepared sauces and jellies, as it can produce inflammation and immunodeficiency and has been found to cause colitis and anaphylaxis in humans.
It has been suggested that as many as 80% of sufferers have low stomach acid (hypochlorhydria).
Foods should be eaten slowly and be well chewed. Eat in a calm atmosphere; do not read or watch television while eating. Any influence that may disrupt good digestion should be avoided.
Dr. McCann, originally with Kaiser Permanente in Ohio, has pioneered a dramatic, experimental treatment for inflammatory bowel disease which has induced a rapid remission in 16 out of 20 patients with ulcerative colitis. A two-day course of multiple broad-spectrum antibiotics to "decontaminate" the gut is followed by administration of defined strains of E. coli, and Lactobacillus acidophilus to produce a "reflorastation" of the colon. Others have not achieved this same degree of success. It may need to be combined with the specific carbohydrate diet described in the book Breaking the Vicious Cycle.
Stool analysis or a pancreatic trial will reveal if pancreatic enzymes are necessary.
Smokers have lower than average rates of ulcerative colitis, but higher than average rates of Crohn's disease. Some patients with ulcerative colitis, in fact, have reported that their disorder began after they quit smoking, and many studies have reinforced the association between smoking and protection against ulcerative colitis. Studies are showing that the nicotine patch helps to induce remission and reduce symptoms in almost 40% of patients who use it for four weeks. Another study found, however, that patches are not useful for maintaining remission. Side-effects, particularly in nonsmokers, include nausea, lightheadedness, and headache. Investigators are studying methods of applying nicotine directly into the colon. (No one should smoke for relief of ulcerative colitis symptoms; the risks from cigarettes far outweigh the potential benefits of their nicotine.)
Ulcerative colitis is both an autoimmune disorder and sensitive to stress. Using hydrocortisol to reduce inflammation followed by physiologic replacement doses when indicated is a reasonable supportive therapeutic strategy.
As many as 50% of sufferers will improve by avoiding food allergens such as dairy, wheat, corn and eggs.
Some doctors have reported reduced pain with the use of MSM.
Rectal insufflation of ozone can hasten tissue repair and kill bacteria that may be slowing the healing process.
Unresolved grief is sometimes a hidden contributing factor. Resolving the issue as completely as possible may hasten healing and reduce relapses.
Whether by supplement or by enema, pilot studies suggest butyrate is useful in reducing symptoms and restoring indicators of colon health in ulcerative colitis, although one study showed no benefit over placebo. Several doctors claim that many people are helped by butyrate enemas.
Butyrate by enema has substantially reduced the number of bowel movements and amount of bleeding in patients who have not responded to other therapies. This is especially true when the distal colon is involved – an area where the enema can easily reach.
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