What is the Cause of Unexplained Fever?

What Causes Unexplained Fever?

Unexplained fever can have various causes, ranging in severity from 'minor' to 'generally fatal'. Finding the true cause means ruling out or confirming each possibility – in other words, diagnosis.

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Diagnosis is usually a complex process due to the sheer number of possible causes and related symptoms. In order to diagnose unexplained fever, we could:

Research the topic
Find a doctor with the time
Use a diagnostic computer system.

The process is the same, whichever method is used.

Step 1: List all Possible Causes

We begin by identifying the disease conditions which have "unexplained fever" as a symptom. Here are eight of many possibilities (more below):

Ulcerative Colitis
Crohn's Disease
Malaria
Non-Hodgkin's Lymphoma
Juvenile Rheumatoid Arthritis
Cerebral Gland Dysfunction
Zinc Toxicity
HIV/AIDS

Step 2: Build a Symptom Checklist

We then identify all possible symptoms and risk factors of each possible cause, and check the ones that apply:

occasional unexplained nausea

significant neck pain

frequent swollen axillary nodes

frequent 'chills'

frequent mucus in stools

elevated eosinophil count

regular unexplained vomiting

non-vaginal candidiasis

swollen axillary nodes

being anxious/nervous

morning stiffness lasting hours

pitted nails

... and more than 100 others

Step 3: Rule Out or Confirm each Possible Cause

A differential diagnosis of your symptoms and risk factors finds the likely cause of unexplained fever:

Cause	Probability	Status
Malaria	96%	Confirm
Non-Hodgkin's Lymphoma	29%	Unlikely
Cerebral Gland Dysfunction	26%	Unlikely
Crohn's Disease	0%	Ruled out
Juvenile Rheumatoid Arthritis	0%	Ruled out
HIV/AIDS	0%	Ruled out
Zinc Toxicity	0%	Ruled out
Ulcerative Colitis	0%	Ruled out

* This is a simple example to illustrate the process

Arriving at a Correct Diagnosis

The Analyst™ is our online diagnosis tool that learns all about you through a straightforward process of multi-level questioning, providing diagnosis at the end.

In the Metabolic Symptoms section of the questionnaire, The Analyst™ will ask the following question about frequency of unexplained fevers:

How often do you get unexplained fevers?

Possible responses:

→ Never / rarely / don't know
→ Occasionally - one or two per year
→ Frequently - several/many per year

Based on your response to this question, which may indicate either occasional unexplained fevers or frequent unexplained fevers, The Analyst™ will consider possibilities such as:

Chronic / Hidden Infection

Crohn's Disease

Epstein-Barr Virus (EBV)

HIV/AIDS

Hypothalamus / Pituitary / Pineal Dysfunction

Juvenile Rheumatoid Arthritis

Lupus, SLE (Systemic Lupus Erythematosus)

A less common but more serious constitutional feature of SLE is persistent fever.

Malaria

Symptoms of malaria include fever and flu-like illness, including shaking chills, headache, muscle aches, and tiredness.

Non-Hodgkin's Lymphoma

Ovarian Cancer