Your Basophil Count

What Causes Abnormal Basophil Count?

Abnormal basophil count can have various causes, ranging in severity from 'minor' to 'generally fatal'.  Finding the true cause means ruling out or confirming each possibility – in other words, diagnosis.

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Diagnosis is usually a complex process due to the sheer number of possible causes and related symptoms.  In order to diagnose abnormal basophil count, we could:

  • Research the topic
  • Find a doctor with the time
  • Use a diagnostic computer system.
The process is the same, whichever method is used.

Step 1: List all Possible Causes

We begin by identifying the disease conditions which have "abnormal basophil count" as a symptom.  Here are eight of many possibilities (more below):
  • Crohn's Disease
  • Asthma
  • Sinusitis
  • Myelofibrosis
  • Collagen Vascular Disease
  • Chickenpox
  • Eczema
  • Low Progesterone

Step 2: Build a Symptom Checklist

We then identify all possible symptoms and risk factors of each possible cause, and check the ones that apply:
appendix removed after age 20
significant abdominal distension
excessive flatulence
very frequent stools
very angry/hostile disposition
poor mental clarity
elevated lymphocyte count
hot flashes between period
water retention before menstruation
shortness of breath when at rest
orange stool color
occasional painful urge to defecate
... and more than 60 others

Step 3: Rule Out or Confirm each Possible Cause

A differential diagnosis of your symptoms and risk factors finds the likely cause of abnormal basophil count:
Cause Probability Status
Crohn's Disease 90% Confirm
Myelofibrosis 26% Unlikely
Asthma 19% Unlikely
Collagen Vascular Disease 1% Ruled out
Chickenpox 0% Ruled out
Eczema 0% Ruled out
Sinusitis 0% Ruled out
Low Progesterone 0% Ruled out
* This is a simple example to illustrate the process

Arriving at a Correct Diagnosis

The Analyst™ is our online diagnosis tool that learns all about you through a straightforward process of multi-level questioning, providing diagnosis at the end.

If you indicate having had recent lab tests, The Analyst™ will ask further questions including this one:
White Blood Cells - Basophil Percentage [fraction]
Possible responses:
→ Don't know
→ 0 to 2% [0.00-0.02] (normal)
→ 3 to 5% [0.03-0.05] (somewhat elevated)
→ 6 to 10% [0.06-0.10] (elevated)
→ Over 10% [0.10] (high)
Based on your response to this question, which may indicate normal basophil count, somewhat elevated basophil count, elevated basophil count or highly elevated basophil count, The Analyst™ will consider possibilities such as:
Chronic Myelogenous Leukemia (CML)

Basophil levels are normally very low, but a high basophil count can indicate a problem with the production and growth of blood cells in the bone narrow, as occurs in myeloproliferative disorders.

Eczema

Various chronic forms of dermatitis can increase basophil levels.

Progesterone Low or Estrogen Dominance

Increased estrogen can raise basophil levels.

Sinusitis

Chronic sinusitis can raise basophil levels.

... and also rule out issues such as:
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