Corticosteroids: Overview

Corticosteroids are medicines that are similar to the natural hormone cortisone and belong to the family of drugs called steroids.

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Corticosteroids reduce inflammation throughout the body.  This class of drugs also helps normalize your immune system.  Corticosteroids can carry major side effects in some people, including weight gain and mood changes.  Some people may see a rise in blood sugar while taking corticosteroid medications.


Corticosteroids are used in several forms, to treat many different conditions.  Examples include inhalant corticosteroids that are used to prevent asthma attacks, and corticosteroid ointments, creams and gels that are used to treat skin problems.  Common varieties include beclomethasone (Beconase, Vancenase, Vanceril), betamethasone (Diprolene, Lotrisone), hydrocortisone, mometasone (Elocon), prednisone (Deltasone, Orasone), and triamcinolone (Azmacort, Nasacort).

Function; Why it is Recommended

They affect many body processes, including the breakdown of protein, fat, and carbohydrate; the activity of the nervous system; the balance of salt and water; and the regulation of blood pressure.

Due to their widespread effects, these drugs are useful in treating many medical conditions, but they can also have serious side-effects.

Because they reduce itching, swelling, redness, and allergic reactions, they are often used in treating skin problems, severe allergies, asthma, and arthritis.  These drugs also suppress the body's immune response, so they are used in patients who have received organ transplants, to reduce the chance of rejection.  In people whose bodies do not produce enough natural corticosteroids, the drugs can raise the levels of those hormones.  Corticosteroids also are used to treat certain cancers (along with other drugs), and to reduce inflammation in other medical conditions.


Gargling and rinsing the mouth with water after using inhalant corticosteroids helps prevent hoarseness and throat irritation.

Patients who take corticosteroids regularly should not stop taking them suddenly, even if their symptoms improve.  Gradually tapering the dose before stopping the drug completely can allow the body time to adjust.  If directed by a physician to reduce the dose, follow directions exactly and see the physician as often as directed.

Corticosteroid ointments, creams and gels can be absorbed through the skin and travel into the bloodstream.  This is not a problem unless large amounts are absorbed.  When this occurs, unwanted side-effects in other parts of the body are possible.  To reduce the chance of that happening, do not spread the medicine over too large an area and do not cover it with plastic wrap, adhesive bandage, or any other type of airtight covering unless told to by your physician.

Side-Effects; Counter-Indicators and Warnings

Side-effects are generally rare when corticosteroids are used for a short time.  However, prolonged use may lower the body's ability to fight off infections or may make infections harder to treat.  Other common side effects include changes in appetite (increase or decrease), nervousness, restlessness, sleep problems, and indigestion.  These problems usually go away as the body adjusts to the drug and do not require medical treatment.

Less common side-effects may occur with some forms of corticosteroids.  Inhalants may cause dry throat, headache, nausea, skin bruising or thinning, and an unpleasant taste.  Nasal spray forms may irritate the nose or throat, and ointments, gels, or creams may irritate the skin.  Again, these side-effects do not need medical attention unless they don't go away or they interfere with normal activities.

More serious side-effects are not common, but may occur.  If breathing problems, wheezing, or tightness in the chest occur, call a physician immediately.  Additional side-effects do not need emergency care, but should have prompt medical attention.  Anyone who is taking corticosteroids and has any of the symptoms listed below should check with the physician who prescribed the medicine as soon as possible:

  • White, curd-like patches in the mouth or throat
  • Pain when swallowing or eating
  • White patches or sores inside nose or in the anal area
  • Eye pain or vision problems
  • Loss of sense of taste or smell
  • Stomach or abdominal pains, nausea, or vomiting
  • Rash, acne, or other skin problems
  • Swelling of face, eyelids, or lips
  • Unusual tiredness or weakness
  • Stuffy, dry, or runny nose (continuing over time)
  • Watery eyes (continuing over time)
  • Black, tarry stools
  • Irregular heartbeat
  • Menstrual problems
  • Muscle cramps, weakness, or pain
  • Rapid weight gain
  • Unusual marks or bruises
  • Wounds that won't heal
  • Confusion, excitement, restlessness, mood swings, or unusual or disturbing thoughts or feelings
  • Hallucinations.

In children and teenagers, these medicines can stop or slow growth and affect the function of the adrenal glands (small glands located above each kidney, which secrete natural corticosteroids).  Another possible problem for children is that corticosteroids may make infections such as chickenpox and measles more serious.  In older people, corticosteroids may increase the risk of high blood pressure and bone disease.  Bone problems from corticosteroids are especially likely in older women.

Corticosteroids may interact with a variety of other medicines.  When this happens, the effects of one or both of the drugs may change, or the risk of side-effects may be greater.  Anyone who takes corticosteroids should let the physician know all other medicines he or she is taking.  Among the drugs that may interact with corticosteroids are: Insulin and diabetes medicines; Heart medicine such as digitalis; Diuretics (water pills); Medicine containing potassium or sodium; Immunizations (vaccinations); Cyclosporine (Sandimmune); Blood thinners, such as warfarin (Coumadin); Estrogen drugs, such as conjugated estrogens (Premarin) or oral contraceptives; Antacids (if taken frequently).

Patients taking corticosteroids over long periods may need to follow special diets, reducing the amount of sodium or increasing the amount of protein they eat, for example.

People with certain medical conditions or who are taking certain other medicines can have problems if they take corticosteroids.  Corticosteroids can also cover up the symptoms of some medical problems: if the condition gets worse, the patient has no way of knowing it.  Before taking these drugs, be sure to let the physician know about any of these conditions:

  • Allergies: Anyone who has had unusual reactions to corticosteroids in the past should let his or her physician know before taking the drugs again.  The physician should also be told about any allergies to foods, dyes, preservatives, or other substances.
  • Pregnancy: Too much use of corticosteroids during pregnancy may cause problems in the baby after it is born, such as slower growth.  Nasal and inhalant forms of the drugs are considered safer to use in pregnancy than are corticosteroids taken by mouth or injection.  When used properly, corticosteroid ointments, creams, and gels – used to treat skin conditions – are not known to cause any problems if used during pregnancy.
  • Breastfeeding: The safety of using corticosteroids while breastfeeding depends on the type of corticosteroid and the form in which it is being used.  When taken by mouth or injection, for example, the drugs pass into breast milk and may cause growth problems in nursing babies.  Creams, gels, and other forms that are applied to the skin are not known to cause problems in nursing babies whose mothers use them.  However, these medicines should not be applied to the breasts just before breastfeeding.  In general, women who are breastfeeding should ask their physicians before using any type of corticosteroid.
  • Diabetes: Corticosteroids may affect blood sugar levels.  Any person with diabetes who notices changes in blood or urine test results while taking corticosteroids should check with a physician.
  • Other medical conditions: Before using corticosteroids, people with any of the following medical problems should make sure their physicians are aware: Osteoporosis or any other bone disease; Current or past tuberculosis; Glaucoma or cataracts; Infections of any type (virus, bacteria, fungus, amoeba); Sores in the nose or recent nose surgery (if using nasal spray forms of corticosteroids); Underactive or overactive thyroid; Liver disease; Stomach or intestine problems; Heart disease; High blood pressure; High cholesterol; Kidney disease or kidney stones; Myasthenia gravis; Systemic lupus erythematosus (SLE); Emotional problems; Skin conditions that cause the skin to be thinner to bruise more easily.
  • Use of certain medicines: Taking corticosteroids with certain other drugs may affect the way the drugs work or may increase the chance of side-effects.

On This Page


Corticosteroids can help with the following:


Oral Lichen Planus

Corticosteroids (topical, oral or by injection) may reduce the inflammation caused by oral lichen planus.


Alopecia (Hair Loss)

Topical corticosteroids (medium to very high potency) or subcutaneous steroid injection.

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