Methionine: Overview

Methionine is one of the essential amino acids, and as such is not synthesized by the human body.  Methionine is one of only two amino acids that contains a sulfur group, important for methionine's role in the pathway of glutathione "charging".

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Methionine is found in animal products, and is important to control fat levels in the liver and the arteries.  In the absence of high animal product intake, there is a danger of not getting enough methionine.  This is the most common dietary deficiency seen in vegetarians.

Plant foods contain methionine as well: beans, seeds, onions, peanuts, lentils, and some grains.

Function; Why it is Recommended

Methionine acts as a methyl donor via SAM (S-adenosylmethionine), one of the principle sources of methyl groups in the body.  Listed as a lipotropic agent in the Merck Index, methionine is able to decrease the deposition and increase the movement of fat from the liver.

Methionine prevents fat build-up by assisting in the breakdown of fats; it detoxifies the digestive system; it is a powerful antioxidant; it reduces histamine levels; helps women excrete estrogen; helps to detoxify the liver.

Long-term use of methionine has been used to treat a variety of chronic liver conditions.

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Methionine can help with the following:

Environment / Toxicity

Copper Toxicity

Methionine is a useful treatment for copper poisoning and for lowering serum copper.


Histadelia (Histamine High)

Methionine supplements lower blood levels of histamine by increasing histamine breakdown.


Gilbert's Syndrome

Methionine, administered as SAM, resulted in a significant decreases in serum bilirubin in patients with Gilbert's syndrome in a recent clinical study.  SAM has been used with favorable results in a variety of other chronic liver diseases.  TMG also converts to SAMe while being considerably less expensive.

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