Gilbert's Syndrome

Gilbert's Syndrome: Overview

Gilbert's Syndrome, characterized by a chronically elevated serum bilirubin level (1.2 to 3.0mg/dL), is the most common of all benign unconjugated hyper-bilirubinemias.  Previously considered rare, this disorder is now known to affect as much as 5% of the general population.

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Signs and Symptoms

The condition is usually asymptomatic, although some patients do complain about anorexia, malaise, and fatigue.  In a small study, the most common symptom was chocolate and sweet craving followed by fatigue.

Diagnosis and Tests

Mild unconjugated hyperbilirubinemia is the only significant laboratory abnormality, which is important clinically because it is often misdiagnosed as chronic hepatitis.

Signs, symptoms & indicators of Gilbert's Syndrome:

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Conditions that suggest Gilbert's Syndrome:

Lab Values

Elevated Bilirubin Levels

One common – and harmless – cause of elevated bilirubin is Gilbert's syndrome, a deficiency in an enzyme that helps break down bilirubin.

Recommendations for Gilbert's Syndrome:

Amino Acid / Protein

Methionine

Methionine, administered as SAM, resulted in a significant decreases in serum bilirubin in patients with Gilbert's syndrome in a recent clinical study.  SAM has been used with favorable results in a variety of other chronic liver diseases.  TMG also converts to SAMe while being considerably less expensive.

Supplements

TMG (Trimethylglycine)

Methionine, administered as SAM, resulted in a significant decreases in serum bilirubin in patients with Gilbert's syndrome in a recent clinical study.  SAM has been used with favorable results in a variety of other chronic liver diseases.  TMG also converts to SAMe while being considerably less expensive.

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