Histadelia (Histamine High)

Histadelia (Histamine High): Overview

Histadelia, more common in males, is characterized by elevated blood levels of histamine.

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This is a disorder, prominent in males, of too much histamine in the blood, as opposed to histapenia in which case there is too little.

Signs and Symptoms

Symptoms include hyperactivity, compulsions, obsessions, inner tensions, blank mind episodes, phobias, chronic depression, and strong suicidal tendencies.  Physical signs can include little tolerance for pain, rapid metabolism, lean build, profuse sweating, seasonal allergies, and frequent colds.

Treatment and Prevention

The treatment of histadelia requires great patience because six to ten weeks are often needed before the beginning of significant improvement.  The treatment usually takes twelve months to complete.

Signs, symptoms & indicators of Histadelia (Histamine High):

Symptoms - Allergy

Excess nose/throat mucus

Histamine can cause additional mucus production.

Symptoms - Environment


Symptoms - Gas-Int - General

Symptoms - Head - Mouth/Oral


Symptoms - Metabolic


Histamine speeds up metabolism producing a tendency towards hyperactivity.

Symptoms - Mind - Emotional


Symptoms - Mind - General

Being a motivated person or being highly motivated

Those with elevated histamine (histadelics) tend to work compulsively.

Good creativity/imagination

Histadelics are often highly creative.

Symptoms - Nervous


Symptoms - Reproductive - General


Symptoms - Skeletal

Slender fingers and toes

Histadelics often have long fingers and toes.

Stubby fingers and toes

Histadelics often have long fingers and toes.

Conditions that suggest Histadelia (Histamine High):


Addictions / Addictive Tendencies

Nutritional treatment for drug and alcohol users will depend on the results of a test for blood histamine levels.  In one series of such analysis, all users proved to have high histamine levels, leading the scientist to conclude that this abnormality – with its impact on brain function – is a major force in creating addiction. [Nutrition Guide for the Prevention and Cure of Common Ailments and Diseases, Carlton Fredericks, PhD. p.58]






The overarousal seen in histadelia may contribute to insomnia.

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Histadelia (Histamine High) can lead to:



Histadelics are often chronically and suicidally depressed.

Histadelia (Histamine High) could instead be:



Some 15-20% of "schizophrenic" patients are in fact suffering from histadelia, which shares similar symptoms and can be misdiagnosed.

Recommendations for Histadelia (Histamine High):

Amino Acid / Protein


Methionine supplements lower blood levels of histamine by increasing histamine breakdown.

Laboratory Testing

Test Copper Levels

Testing serum or hair copper levels is usually adequate for evaluating copper status when low levels of copper are suspected and hair contamination with copper can be ruled out.  When in doubt, it would be better to use more accurate tests such as the 24 hour urine copper or serum ceruloplasmin.

Test Folic Acid Levels

Under certain conditions, such as anticipated or actual pregnancy, a simple lab test for serum folate levels is advisable.  If the test results show low levels, supplementation should be considered to prevent potential birth defects.



Not recommended
Folic Acid

Histadelics should avoid supplemental folic acid as it can produce excess histamine.  In fact, anti-folate drugs may be required.  Folic acid increases depression in histadelic patients and a trial of folic acid could be used to distinguish between histapenics and histadelics.  In extreme cases, folic acid in food or in multivitamins is enough to produce the adverse effects.

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Weak or unproven link: may be a sign or symptom of; may suggest
Weak or unproven link:
may be a sign or symptom of; may suggest
Strong or generally accepted link: is often a sign or symptom of; often suggests; often leads to; is sometimes misdiagnosed as
Strong or generally accepted link:
is often a sign or symptom of; often suggests; often leads to; is sometimes misdiagnosed as
Definite or direct link: usually leads to
Definite or direct link:
usually leads to
Weakly counter-indicative: may contraindicate
Weakly counter-indicative:
may contraindicate
Strong counter-indication: often contraindicates
Strong counter-indication:
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Moderately useful: often helps with
Moderately useful:
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Very useful: is highly recommended for
Very useful:
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Often counterindicated: is often not recommended for
Often counterindicated:
is often not recommended for
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