Calcium-D-Glucarate: Overview

Calcium D-glucarate is a botanical extract found in grapefruit, apples, oranges, broccoli and brussels sprouts.  Scientists are discovering that, like antioxidants such as vitamin C, carotenoids, and folic acid, D-Glucarate appears to protect against cancer and other diseases – but through a different mechanism.

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Although D-Glucaric Acid is a natural substance found in fruits and vegetables, our bodies also make small amounts of it as part of a process called 'glucuronidation' which is one of the body's natural detoxification processes.


D-Glucarate is naturally found in some vegetables and fruits, including cruciferous vegetables, bean sprouts and apples.  D-Glucarate in the form of its calcium salt, Calcium D-Glucarate, is marketed as a nutritional supplement.

Function; Why it is Recommended

Other antioxidants work by neutralizing toxic free radical damage in the body.  There are however, other mechanisms by which the human body can detoxify itself.  Glucuronidation is a detoxification process that occurs when toxins or carcinogens are combined with water-soluble substances, thus making them more easily removed from the body.  D-glucarate has been shown to support this vital process by inhibiting an enzyme called beta-glucuronidase.  When levels of this enzyme become elevated, it reverses the critical glucuronidation mechanism and releases the toxins back into the bloodstream.

One example of the importance of glucuronidation can be seen in the risk factors for breast cancer.  Excess levels of free estrogens and the beta-glucuronidase enzyme are associated with increased incidence of breast cancer.  The beta-glucuronidase enzyme is associated with an increase in the number of estrogen receptors.  D-Glucarate has been shown to lower estrogen receptors while reducing tumor growth.  When breast cells hyper-proliferate in response to excess estrogen stimulation, the risk of breast cancer increases.

In men, excess estrogen stimulation in the prostate gland can result in benign enlargement.  D-Glucarate suppresses the "bad" enzyme beta-glucuronidase, thus helping to protect against the carcinogenic effects of estrogen.  This discovery helps explain why those who eat certain types of vegetables and fruits have relatively low rates of cancer.

Calcium D-Glucarate is an excellent detoxifying agent.  It assists and strengthens glucuronidation, the important Phase 2 detoxification pathway.  This reduces serum estrogen levels and assists in the detoxification and excretion of xenobiotics, lipid-soluble toxins, and steroid hormones.

Calcium D-glucarate may help with the following:

Estrogen Removal
Many toxic chemicals in our home and garage increase levels of xenoestrogens (estrogen-like chemicals.)  These disrupt hormone balance in men and women.  Glucarate facilitates estrogen removal, and improves estrogen by-product formation so it may ease prostate conditions, PMS and other hormonal concerns.

For Bodybuilders
Glucarate improves physique by reducing total estrogen load; means it can lessen fluid retention and reverse gynecomastia ('man boobs').

Cholesterol Lowering
Preliminary results in humans show that glucarate can significantly reduce total cholesterol, LDL and triglycerides.

Cancer Prevention
Animal studies suggest Calcium D-Glucarate not only reduces risk, but may prevent tumor growth in the skin, breast, liver, colon, lung, bladder, and prostate.  Women with estrogen-dependent tumors (and men with prostate cancer) should absolutely ask about taking glucarate since it can reduce total estrogen load and improve estrogen metabolite ratios.

For people who suffer contamination from heavy metals/plasticizers and those with Multiple Chemical Sensitivity (MCS), auto-immune disorders or fibromyalgia, the detoxifying effect of glucarate offers great benefits by reducing total toxin burden.  Glucarate helps us to properly eliminate used-up medications.

Without enough D-Glucarate, the toxins that our bodies have isolated and 'packaged' for expulsion come unraveled and re-enter our circulation.

The detoxification of estrogen aspect is useful for bodybuilders, as well as men or women suffering symptoms of estrogen dominance.


Dosages vary from 500mg – 3,000mg total per day.


Glucarate has no known major side-effects and is safely taken in combination with antioxidants, protein shakes or medications.

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Calcium-D-Glucarate can help with the following:

Tumors, Malignant

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Calcium-D-Glucarate can help prevent the following:

Tumors, Malignant

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May be useful: may help with; may help prevent
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