Oxidative Stress

Definition of Oxidative Stress:

An imbalance between free radicals and antioxidants in the body in which there are more free radicals present than can be kept in balance by antioxidants.  Although free radicals help fight off pathogens, they start doing damage to fatty tissue, DNA, and proteins when there are too many and this can lead to a wide variety of diseases over time.

Also: Free Radical Damage

Topics Related to Oxidative Stress

Alpha Lipoic Acid

...as a treatment
“...Lipoic acid fights free radical damage in both fatty and watery regions of cells and helps to recycle other antioxidants in what is described as "antioxidant synergism"...”

Alzheimer's Disease

...the condition
“...Increased free radical activity (oxidative stress) appears to fuel Alzheimer's pathology – acting simultaneously as a mediator, product, and trigger for this "clogging" process and its related neural damage...”
...our question about Duration of suboptimally controlled diabetes
“...Activation of this receptor leads to increased oxidative stress that may result in cellular damage...”
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More topics Related to Oxidative Stress

American Skullcap

...as a treatment
“...Both baicalin and baicalein are powerful antioxidants, protecting red blood cells from free radical damage better than vitamin E can...”

Antioxidant Requirement

...the condition
“...However, when large amounts of antioxidant nutrients are taken, they can also act as pro-oxidants by inducing oxidative stress.  Furthermore, pro-oxidant activity can induce either beneficial or harmful effects in biologic systems...”
...relationship to Parkinson's Disease
“The question as to what causes the destruction of the dopamine-producing cells has puzzled researchers for years but a consensus is now emerging that Parkinson's disease is caused by oxidative stress and metal toxicity...”


...recommendation Hawthorn Berry Extract
“...Proanthocyanadins stabilize collagen to prevent cholesterol deposits on arterial walls, prevent free radical damage, reduce peripheral vascular resistance, angina, cholesterol, and increase coronary and myocardial perfusion; hawthorn has a historic use in congestive heart failure; dosage 3 to...”


...as a treatment
“...Other antioxidants work by neutralizing toxic free radical damage in the body...”


...the condition
“...During cataract formation the normal protective mechanisms are unable to prevent free radical damage.  The lens, like many other tissues of the body, is dependent on adequate levels and activities of superoxide dismutase (SOD), catalase, glutathione (GSH), and adequate levels of...”


...as a treatment
“...The anti-aging benefits of Centrophenoxine include protection against free radical damage, increased mental energy, improved memory, and prevention and treatment of stroke and brain injury...”

Chelation Therapy

...as a treatment
“...Abnormally-situated nutritional metals, which speed free radical damage, and toxic metals such as lead, are most easily removed by EDTA...”

Concern Over Wrinkled Skin

...recommendation Sun Exposure Reduction / Sunscreen
“...A new ingredient in some skin care products, beta-glucan, increases the skin's resistance to oxidative stress induced by UVA rays...”

Consequences of Poor Diet

...our question about Amount of dairy product consumption
“...The sugars lactose and galactose that are found in milk can increase oxidative stress and chronic inflammation in the body – both of which are major causes of serious and chronic diseases...”

COPD (Chronic Obstructive Pulmonary Disease)

...recommendation Test Antioxidant Status
Oxidative stress appears to play a role...”

Coronary Disease / Heart Attack

...our question about Low-carbohydrate dieting
“...Uric acid itself has been tied to cardiovascular disease risk in virtually every instance it's been studied over the last 50 years, and may be an independent risk factor by increasing free radical damage or making the blood more susceptible to clotting...”

Dental Metal Removal

...as a treatment
“...The bowel of a healthy person may not be prone to free radical damage, but the damaged bowel of the metal toxic patient is potentially an area for added concern and monitoring.”

Diabetes Type I

...relationship to Alzheimer's Disease
“...Activation of this receptor leads to increased oxidative stress that may result in cellular damage...”
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More topics Related to Oxidative Stress

Diabetes Type II

...relationship to Alzheimer's Disease
“...Activation of this receptor leads to increased oxidative stress that may result in cellular damage...”

Gallbladder Disease

...relationship to Low Melatonin Level
“...Melatonin inhibits cholesterol secretion from the gallbladder, helps convert cholesterol to bile, and as an antioxidant can reduce oxidative stress on the gallbladder...”

Ginkgo Biloba

...as a treatment
“...Ginkgo extracts are used for almost any type of vascular disorder associated with spasms, hypoxia and free radical damage.  Ginkgo is a mild antioxidant and may be useful in asthma, coughs, and allergies...”

Hemochromatosis (Iron overload)

...recommendation Manganese
“Manganese can protect against the free radical damage from excess iron...”


...as a treatment
“...Unfortunately, too much iron can lead to oxidative stress (forming excessive free radicals) and adhesion of blood cells...”

Liver Detoxification / Support Requirement

...the condition
“...flushing; Fatty Infiltration reduction Alcohol avoidance; Low fat diet; High water-insoluble fiber consumption; Carnitine supplementation (other lipotropics less effective); Protection from free radical damage Vitamins C, E, Zinc, Selenium, Lipoic acid”
...our question about Exposure to solvents
“Long-term exposure to environmental pollutants and continued assaults on the detoxifying systems may lead to oxidative stress, high levels of phase 1 activity in the liver, and reduced phase 2 detoxification.”

Liver Detoxification Profile

...as a treatment
“...assess the body's capacity to carry out detoxification through functional challenges – caffeine, acetaminophen, and salicylate – which evaluate specific aspects of the detoxification process and free radical damage.  These functional assessments provide a comprehensive profile of the body's detoxification capacity and potential susceptibility to oxidative damage...”

Migraine/Tension Headaches

...relationship to Dehydration
“...Dehydration leads to ... Oxidative stress: A major trigger of migraines...”

Parkinson's Disease

...the condition
“...The finding that Parkinson's disease is almost certainly caused by oxidative stress aggravated by metal toxicity is a major step forward in understanding and eventually conquering the disease...”
...recommendation Heavy Metal Detoxification / Avoidance
“Parkinson's disease is almost certainly caused by oxidative stress aggravated by metal toxicity...”

Silymarin / Milk Thistle

...as a treatment
“...Studies since the 1930s, conducted mainly in Germany, researched that the silymarin found in the herb works to stabilize liver cell membranes and act as an antioxidant to protect liver cells from free radical damage.  It also helps regenerate healthy liver cells and boost the organ's ability to filter toxins from the blood...”

Syndrome X / Metabolic Syndrome

...recommendation Vitamin E
“Vitamin E is an important antioxidant that protects against free radical damage caused by high glucose and insulin levels in the blood...”
...recommendation Selenium
“Selenium is a mineral that works alongside vitamin E as part of the antioxidant protection against free radical damage caused by high insulin levels...”

Test Antioxidant Status

...as a treatment
“...Oxidative stress (caused by free radicals) can also result from exposure to pathogens and inappropriate lifestyle factors such as excessive exercise...”

Test Serum Uric Acid Levels

...as a treatment
“...Oxidative Stress Uric acid may be a marker of oxidative stress, and may have a potential therapeutic role as an antioxidant...”
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