Histapenia (Histamine Low)

Histapenia (Histamine Low): Overview

Serum copper levels in these patients are abnormally high.  Since copper is a brain stimulant and destroys histamine, the elevated serum (and presumably brain) copper level probably accounts for many symptoms, including the low blood histamine level.

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Histapenia (hista-: histamine; -penia: deficiency of) is a shortage of histamine in the body.  Histamine is an important brain chemical involved in many reactions.

Signs and Symptoms

Behavioral symptoms in high-copper histapenia include paranoia and hallucinations in younger patients, but depression may predominate in older patients.  The patient is usually classified as having chronic or process schizophrenia.  Some studies of schizophrenics have revealed high blood copper, as seen in histadelia, with low urinary copper (showing that copper is being retained) as well as low blood zinc.

Treatment and Prevention

The treatment program consists of the administration of zinc, manganese, vitamin C, niacin, vitamin B12, and folic acid.  With this treatment the high blood copper is slowly reduced and symptoms are slowly relieved in several months' time.

Signs, symptoms & indicators of Histapenia (Histamine Low):

Symptoms - Mind - General

Symptoms - Nervous


Conditions that suggest Histapenia (Histamine Low):



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Risk factors for Histapenia (Histamine Low):


(Severe) childhood hyperactivity

Low histamine children are hyperactive while often healthy in other respects.

Histapenia (Histamine Low) could instead be:



It has been found that 50% of patients classified as "schizophrenic" have low histamine levels in the blood and it rises to normal as they improve.  These same patients are found to have high copper levels.  Elevated copper decreases blood histamine.  Excess copper is linked with psychosis.  People with histapenia tend to have classic signs of schizophrenia, including canker sores, difficult orgasm with sex, no headaches or allergies, heavy growth of body hair, ideas of grandeur, undue suspicion of people, racing thoughts, the feeling that someone controls one's mind, seeing or hearing things abnormally, ringing in the ears, and others.

Recommendations for Histapenia (Histamine Low):

Amino Acid / Protein


Laboratory Testing



Copper levels are usually elevated in patients with histapenia.  Manganese and zinc supplementation increase copper excretion.


Zinc should be given once testing confirms a low zinc or high copper level.  Zinc and manganese allow for the normal storage of histamine in both basophils and the brain.  During treatment, the largest tissues of the body – namely the liver and muscles – are flushed of their copper first so that the serum copper may rise to aggravate mental symptoms.  If this occurs then the dose of zinc should be reduced for a two week period.

Not recommended

Excess copper may be acquired from commercial vitamins and minerals or drinking water flowing through copper pipes.  Distilled water may occasionally be needed to reduce copper intake.



Folic Acid

The rationale underlying this treatment is that folic acid in conjunction with vitamin B12 injections raises the blood histamine while lowering the degree of symptoms.

Vitamin C (Ascorbic Acid)

Zinc and manganese with vitamin C remove copper from the tissues.  Copper destroys histamine and therefore as copper levels decrease, histamine levels should return towards normal.

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