Although the term "uremia" literally means the presence of urea (and other nitrogen-containing wastes) in the blood, it is actually the complex terminal stage of kidney failure.
Uremia can also be caused by NSAIDs, especially in older patients who are being treated primarily with ibuprofen for arthritis.
Some of the early signs include lethargy, mental depression, loss of appetite, and edema; later symptoms include diarrhea, anemia, convulsions, coma, and a gray-brown coloration.
Treatment of uremia, which is directed at the underlying kidney disease, is usually with dialysis and renal transplantation.
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