Adrafinil: Overview

Adrafinil stimulates brain activity.  Modafinil, which is similar but even more potent, can be expensive.  Both drugs act on certain receptors, making them more susceptible to norepinephrine.  This increases alertness, concentration, and short term memory, and improves hand-to-eye coordination.  Adrafinil is an alpha-adrenergic agonist chemically related to Modafinil.

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Adrafinil is supplied in 300mg tablets under the trade name Olmifon 300 to 1500mg.  Modafinil is supplied under the trade name Modiodal in 100mg tablets.


100 to 500mg a day is the usual dose.

Side-Effects; Counter-Indicators and Warnings

Side-effects include an increase in liver enzyme levels and therefore usage should be monitored.  Other side-effects include headaches, stomach pain, minor skin irritations, inner tension and mild agitation or aggression.

People with epilepsy, liver or kidney impairment, or those using tranquilizers should avoid Adrafinil and Modafinil.  Caution is advised if used in combination with norepinephrine-stimulating agents such as Yohimbine.

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