Sex Hormone Binding Globulin Level

What Causes Abnormal Sex Hormone Binding Globulin?

In order to deal properly with abnormal sex hormone binding globulin we need to understand and — if possible — remove the underlying causes and risk factors.  We need to ask: "What else is going on inside the body that might allow abnormal sex hormone binding globulin to develop?"

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Accurate diagnosis of the factors behind abnormal sex hormone binding globulin consists of three steps:

Step 1: List the Possible Causative Factors

Identify all disease conditions, lifestyle choices and environmental risk factors that can lead to abnormal sex hormone binding globulin.  Here are three possibilities:
  • Polycystic Ovary Syndrome
  • A Weight Problem
  • Hypothyroidism

Step 2: Build a Symptom Checklist

Identify all possible symptoms and risk factors of each possible cause, and check the ones that apply:
macrocytic red cells
poor concentration during cycle
depression with some anxiety
having low TT4 level
high air pollution exposure
low T3 free level
missing outer third of eyebrows
occasionally feeling unusually cold
elevated TSH
being highly lethargic
poor recovery from exertion
major swelling at front of neck
... and more than 40 others

Step 3: Rule Out or Confirm each Possible Cause

A differential diagnosis of your symptoms and risk factors finds the likely cause of abnormal sex hormone binding globulin:
Cause Probability Status
A Weight Problem 93% Confirm
Polycystic Ovary Syndrome 30% Unlikely
Hypothyroidism 4% Ruled out
* This is a simple example to illustrate the process

Arriving at a Correct Diagnosis

The Analyst™ is our online diagnosis tool that learns all about you through a straightforward process of multi-level questioning, providing diagnosis at the end.

If you indicate having had recent lab tests, The Analyst™ will ask further questions including this one:
If your Sex Hormone Binding Globulin (SHBG) level has been measured, what was the result?
Possible responses:
→ Don't know
→ Very low
→ Somewhat low
→ Normal
→ Elevated
Based on your response to this question, which may indicate very low SHBG, moderately low SHBG, normal SHBG or elevated SHBG, The Analyst™ will consider possibilities such as:
Hypothyroidism

Thyroid diseases such as hypothyroid affect hormonal balance.

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