Sex Hormone Binding Globulin Level

What Causes Abnormal Sex Hormone Binding Globulin?

In order to deal properly with abnormal sex hormone binding globulin we need to understand and — if possible — remove the underlying causes and risk factors.  We need to ask: "What else is going on inside the body that might allow abnormal sex hormone binding globulin to develop?"

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Accurate diagnosis of the factors behind abnormal sex hormone binding globulin consists of three steps:

Step 1: List the Possible Causative Factors

Identify all disease conditions, lifestyle choices and environmental risk factors that can lead to abnormal sex hormone binding globulin.  Here are three possibilities:
  • Hypothyroidism
  • A Weight Problem
  • Polycystic Ovary Syndrome

Step 2: Build a Symptom Checklist

Identify all possible symptoms and risk factors of each possible cause, and check the ones that apply:
having high percentage body fat
regular unexplained sadness/crying
hyperthyroidism in family members
difficulty losing weight
poor cold weather tolerance
hypothyroidism in family members
major swelling at front of neck
having hard stools
tonsils/adenoids out before age 20
high iodine consumption
major joint pain/swelling/stiffness
very low free T4
... and more than 40 others

Step 3: Rule Out or Confirm each Possible Cause

A differential diagnosis of your symptoms and risk factors finds the likely cause of abnormal sex hormone binding globulin:
Cause Probability Status
A Weight Problem 92% Confirm
Polycystic Ovary Syndrome 25% Unlikely
Hypothyroidism 5% Ruled out
* This is a simple example to illustrate the process

Arriving at a Correct Diagnosis

The Analyst™ is our online diagnosis tool that learns all about you through a straightforward process of multi-level questioning, providing diagnosis at the end.

If you indicate having had recent lab tests, The Analyst™ will ask further questions including this one:
If your Sex Hormone Binding Globulin (SHBG) level has been measured, what was the result?
Possible responses:
→ Don't know
→ Very low
→ Somewhat low
→ Normal
→ Elevated
Based on your response to this question, which may indicate very low SHBG, moderately low SHBG, normal SHBG or elevated SHBG, The Analyst™ will consider possibilities such as:
Problems Caused By Being Overweight

Obesity tends to increase the levels of sex hormone (estrogen, testosterone) activity, and decrease levels of sex hormone binding globulin.

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