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The macula is found at the center of the retina where the incoming rays of light are focused. The macula is very important, being responsible for what we see straight in front of us, the vision needed for detailed activities such as reading and writing, recognizing faces, fine work, and our ability to appreciate color.
Macular Degeneration is a condition whereby the delicate cells of the macula become damaged and stop working. We do not know why this is, although it tends to happen as people get older. Vision loss usually occurs gradually and typically affects both eyes at different rates.
Causes & Development The root causes are still unknown. There are two forms of age-related macular degeneration, namely "wet" and "dry".- For many people the visual cells simply cease to function, like the colors fading in an old photograph - this is known as 'dry' degeneration. 70% of patients have this "dry" form, which involves thinning of the macular tissues and disturbances in its pigmentation.
- The other 30% have the "wet" form, which can involve bleeding within and beneath the retina, opaque deposits, and eventually scar tissue. The "wet" form accounts for 90% of all cases of legal blindness amongst macular degeneration patients. The dry form will often begin to convert to wet, with the appearance of abnormal choroidal blood vessels - angiogenesis. The reason why angiogenesis occurs is unknown but it is believed that this additional blood vessel development is somehow caused by deposits being left in the back of the eye. These deposits are similar to age spots on the skin. These new blood vessels are fragile and have a propensity to leak and bleed, eventually forming scar tissue and resulting in irreversible vision loss.
- Different forms of macular degeneration may occur in younger patients. These non-age-related cases may be linked to heredity, diabetes, nutritional deficits, head injury, infection, or other factors.
- Inherited macular degeneration, which appears in some families but not in others, is known as macular dystrophy. Since macular degeneration affects most patients later in life, it is difficult to study successive generations in a family. Recent studies of twins indicate that both genetic and non-genetic factors play important roles in age-related macular degeneration. If several members of a family are sufferers then it is very important that other members have their eyes checked regularly.
- It has been demonstrated that the blue rays of the light spectrum seem to accelerate macular degeneration more than the others. This means that very bright light, such as sunlight or its reflection in the ocean and desert, may worsen macular degeneration. Special sunglasses that block out the blue end of the spectrum may decrease the progress of the disease.
- Hypertension tends to make some forms of macular degeneration worse, particularly in the "wet" form where the retinal tissues are invaded by new blood vessels. The medications used to treat hypertension have not been shown to have any direct effect on macular degeneration, but they may slow progression of the disease by reducing hypertension.
- Any type of smoking or exposure to tobacco smoke can accelerate the development of the "wet" type of macular degeneration.
Signs & Symptoms In the early stages your central vision may become blurred or distorted, with things looking an unusual size or shape. This may happen quickly or develop over several months. You may be very sensitive to light or actually see lights that are not there. People with the advanced condition will often notice a blank patch or dark spot in the centre of their sight. This makes activities like reading, writing and recognizing small objects or faces very difficult.
The formation of new blood vessels and exudates ("drusen") from blood vessels in and under the macula is often the first physical sign that macular degeneration may develop.
The following are NOT known to be linked to macular degeneration: floaters (moving spots caused by debris floating in the vitreous fluid between the lens and the retina); dry eye syndromes; cataracts and cataract surgery.
Diagnosis & Tests Early detection is important because a patient destined to develop macular degeneration can sometimes be treated before symptoms appear and this may delay or reduce the severity of the disease. Furthermore, as we develop better treatments for macular degeneration, whether they are medicinal, surgical, or low vision aids, those patients diagnosed with macular degeneration can sooner benefit from them.
Treatment & Prevention At this time there is no known cure for macular degeneration. There are ways to slow macular degeneration, depending on the type and the degree of the condition. Current treatments fall into three main categories:- Nutritional Intervention.
- Surgery. Laser surgery to remove the scar produced by macular degeneration has been successful in about 10% of people with disciform degeneration, mainly the younger patients. If the degeneration is associated with leaking blood vessels in the center of the macula and vision is worse than 20/70 then laser surgery called photocoagulation is recommended. This will not improve vision but generally reduces further vision loss. Unfortunately for most people, the area of degeneration is in the middle of the macula, at its focal point. This means that treatment cannot be given because the scars produced by the laser would make central vision worse rather than better. 'Dry' degeneration cannot be treated by laser.
Retinal transplantation is a new experimental approach to macular degeneration, but will require research to determine its safety and effectiveness. - Making the most of remaining vision. Low vision aids (such as brighter reading lights, magnifying glasses and more sophisticated devices) and techniques for maximizing the use of peripheral vision are used to help patients adapt better to their loss of central vision.
Prognosis; Seek medical attention if There is some good news: macular degeneration is not painful, and never leads to total blindness. It is the most common cause of poor sight in people over 60 but never leads to complete sight loss because it is only the central vision that is affected. Macular degeneration never affects vision at the outer edges of the eye, so most sufferers will have enough side vision to get around and keep their independence.
The bad news is that if you have macular degeneration in one eye then it will usually develop in the other also. In the early stages, only one eye may be affected, but as the disease progresses, both eyes are usually affected. Even with a loss of central vision, however, color vision and peripheral vision may remain clear.
In some cases, macular degeneration may be active and then slow down considerably, or even stop progressing for many years.
The following signs may be indicative of macular problems and anyone experiencing these symptoms should consult an ophthalmologist immediately:- The major risk factors: aging, atherosclerosis and hypertension.
- Straight lines appear distorted and, in some cases, the center of vision appears more distorted than the rest of the scene.
- A dark, blurry area or "white-out" appears in the center of vision.
- Color perception changes or diminishes.
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Signs, symptoms & indicators of Macular Degeneration: |  |  |  | | Symptoms - Head - Eyes/Ocular | Vision disturbances | In the early stages, central vision may be blurred or distorted, with things looking an unusual size or shape. This may happen quickly or develop over several months. |
(High) sensitivity to bright light | Those suffering from macular degeneration may be very sensitive to light or actually see lights that are not there. |
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Conditions that suggest Macular Degeneration:
Risk factors for Macular Degeneration: |  |  |  | | Addictions | Cigarette Smoke Damage | Any type of smoking or exposure to tobacco smoke can accelerate the development of the "wet" type of macular degeneration. Smokers on average exhibit only half the density of yellow macular pigment (lutein and zeaxanthin) and develop macular degeneration 7 years sooner than non-smokers. |
| Family History |
Macular degeneration in family | Children and young people can suffer from an inherited form of macular degeneration called macular dystrophy. Sometimes several members of a family will suffer from this, and if this is the case in your family it is very important that you have your eyes checked regularly. |
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Recommendations and treatments for Macular Degeneration: |  |  |  | | Amino Acid / Protein | L-Glutathione | Researchers have found that age-related macular degeneration correlates with low glutathione levels. When taking into consideration other variables such as smoking, age, cardiovascular disease and multivitamin use, depletion of glutathione by itself was thought to be a major contributing factor behind macular degeneration. [British Journal of Ophthalmology, 1994; 78 [10], pp.791-4)] |
| Botanical |
Bindweed | Bindweed prevents new vessel growth and may help stop the scarring and permanent damage seen with wet macular degeneration. The suggested dose is two 250mg capsules per day. |
Ginkgo Biloba | Ginkgo Biloba appears to reduce the risk of macular degeneration. [Recent Results in Pharmacology and Clinic, Fuenfgeld FW, ed. Berlin: Springer-Verlag, 1988; pp.231-6] |
| Diet |
Increased Fruit/Vegetable Consumption | There is evidence that eating fresh fruits and dark green, leafy vegetables (such as spinach and collard greens) may delay or reduce the severity of age-related macular degeneration. |
Low/Decreased Fat Diet | Mineral |
Zinc | Oral use of zinc has produced improvement in vision. Intravenous administration along with selenium have demonstrated benefits in the treatment of macular degeneration. According to researchers at Harvard University, however, zinc has shown mixed results. [Arch Ophthalmol 1988:106, pp.192-8] |
| Nutrient |
Lycopene | Vitamins |
Vitamin E |
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Preventive measures against Macular Degeneration: |  |  |  | | Botanical | Bilberry | Bilberry contains compounds which act as antioxidants in the retina, making it a possible preventive measure for macular degeneration [Klin Monatsbl Augenheikld Beih 1981;178: pp.386-9]. It also strengthens capillaries in the retina and reduces hemorrhaging [Minerva Med 1977;68: pp.3565-81]. An oral dose is in the range of 40 to 80mg (24% anthocyanosides) per day. |
| Nutrient |
Lutein | Lutein, an antioxidant found in spinach and kale, works extremely well in protecting the retina against sunlight damage [Methods Enzymol 1992:213: pp.360-6]. Supplementation with 6mg of Lutein daily may decrease the occurrence of macular degeneration by more than 50% [JAMA 1994:272: pp.1413-20]. Lutein is one of the primary antioxidants for the macula rather than for the lens of the eye. |
| Vitamins |
Vitamin C (Ascorbic Acid) | Taking anti-oxidants such as vitamins C and E has beneficial protective effects against age-related macular degeneration (AMD). Since oxidative damage of the eye can cause macular degeneration, taking antioxidants may lower the disease’s occurrence. People with high levels of vitamin C, vitamin E and selenium appear to have a 70% lower risk of developing macular degeneration. [Arch Ophthalmol, December 1995:113(12, 15): pp.18-23; Arch Ophthalmol 1993:111: pp.104-9]
Long-term use of multiple antioxidants plus zinc and copper clearly reduced the risk of developing advanced AMD and the rate of visual acuity loss in a randomized, double-blind, placebo-controlled trial of 3,640 older adults (aged 55-80 years) with preexisting retinal abnormalities, advanced AMD or vision loss due to AMD who were followed for an average of 6.3 years. [AREDS Report No. 8. Arch Ophthalmol 2001;119(10): pp.1417-1436] |
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KEY |  | Weak or unproven link |  |  | Strong or generally accepted link |  |  | Proven definite or direct link |  |  | May do some good |  |  | Likely to help |  |  | Highly recommended |
GLOSSARY
Age Spots (Liver Spots) Flat, brown areas usually found on the face, hands, back and feet. They vary in size from 1/8 of an inch to several inches (0.3cm to several cm) and are associated with aging, but long-term sun exposure is also a major cause.
AIDS Acquired Immune Deficiency Syndrome. An immune system deficiency disorder that suddenly alters the body's ability to defend itself. The AIDS virus invades the T4 helper/inducer lymphocytes and multiplies, causing a breakdown in the body's immune system, eventually leading to overwhelming infection and/or cancer, with ultimate death.
Antioxidant (Antioxidants) A chemical compound that slows or prevents oxygen from reacting with other compounds. Antioxidants are substances that protect cells from oxidative damage caused by molecules called free radicals. These chemicals can damage important parts of cells, such as proteins, membranes, and DNA. Some antioxidants have been shown to have cancer-protecting potential because they neutralize free radicals. Examples include vitamins C and E, beta carotene, the minerals selenium and germanium, superoxide dismutase (SOD), coenzyme Q10, catalase, and some amino acids.
Atherosclerosis Common form of arteriosclerosis associated with the formation of atheromas which are deposits of yellow plaques containing cholesterol, lipids, and lipophages within the intima and inner media of arteries. This results in a narrowing of the arteries, which reduces the blood and oxygen flow to the heart and brain as well as to other parts of the body and can lead to a heart attack, stroke, or loss of function or gangrene of other tissues.
Cardiovascular Pertaining to the heart and blood vessels.
Carotenoid A group of red, orange and yellow pigments found in plant foods and in the tissues of organisms that consume plants. Carotenoids have antioxidant activity and some, but not all, can act as precursors of vitamin A. Studies have shown that several carotenoids other than beta-carotene are potent antioxidants that provide profound health benefits. Because of this, the scientific community has now recognized the importance of natural mixed carotenoids including beta-carotene.
Cataract (Cataracts) A steadily worsening disease of the eye in which the lens becomes cloudy as a result of the precipitation of proteins. Most cataracts are caused by the functions of the body breaking down. Eye trauma, such as from a puncture wound, may also result in cataracts.
Copper An essential mineral that is a component of several important enzymes in the body and is essential to good health. Copper is found in all body tissues. Copper deficiency leads to a variety of abnormalities, including anemia, skeletal defects, degeneration of the nervous system, reproductive failure, pronounced cardiovascular lesions, elevated blood cholesterol, impaired immunity and defects in the pigmentation and structure of hair. Copper is involved in iron incorporation into hemoglobin. It is also involved with vitamin C in the formation of collagen and the proper functioning in central nervous system. More than a dozen enzymes have been found to contain copper. The best studied are superoxide dismutase (SOD), cytochrome C oxidase, catalase, dopamine hydroxylase, uricase, tryptophan dioxygenase, lecithinase and other monoamine and diamine oxidases.
Diabetes Mellitus (Diabetes, Diabetic, Diabetics) A disease with increased blood glucose levels due to lack or ineffectiveness of insulin. Diabetes is found in two forms; insulin-dependent diabetes (juvenile-onset) and non-insulin-dependent (adult-onset). Symptoms include increased thirst; increased urination; weight loss in spite of increased appetite; fatigue; nausea; vomiting; frequent infections including bladder, vaginal, and skin; blurred vision; impotence in men; bad breath; cessation of menses; diminished skin fullness. Other symptoms include bleeding gums; ear noise/buzzing; diarrhea; depression; confusion.
Exudates The feral and congested fluids built up in a bruise or infection. Unlike a transudate, which is merely edema from lymphatic congestion, exudates contain dead cells, erythrocytes, white blood cells and often pus.
Glutathione A natural sulfur-bearing peptide formed from the linking of three amino acids: glutamic acid, cysteine and glycine. Glutathione acts as an antioxidant and detoxicant and is involved with the selenium-containing enzyme glutathione peroxidase. Glutathione is also involved in amino acid transport across cell membranes and is a powerful free radical scavenger and antioxidant that removes unwanted substances from the body.
Hemorrhage (Hemorrhaging) Profuse blood flow.
Hypertension High blood pressure. Hypertension increases the risk of heart attack, stroke, and kidney failure because it adds to the workload of the heart, causing it to enlarge and, over time, to weaken; in addition, it may damage the walls of the arteries.
Macular Degeneration Increasingly poor eyesight often accompanied by light sensitivity, distorted vision and a blank or dark patch in the center of vision.
Milligram (mg, Milligrams) 0.001 or a thousandth of a gram.
Retina (Retinal) A 10-layered, frail nervous tissue membrane of the eye, parallel with the optic nerve. It receives images of outer objects and carries sight signals through the optic nerve to the brain.
Saturated Fat (Saturated Fats) A type of fat that is readily converted to LDL cholesterol and is thought to encourage production of arterial disease. Saturated fats tend to be hard at room temperature. Among saturated fats are animal fats, dairy products, and such vegetable oils as coconut and palm oils.
Scar Tissue Fibrous tissue replacing normal tissues destroyed by injury or disease.
Selenium An essential element involved primarily in enzymes that are antioxidants. Three selenium- containing enzymes are antioxidant peroxidases and a fourth selenium-containing enzyme is involved in thyroid hormone production. The prostate contains a selenium-containing protein and semen contains relatively large amounts of selenium. Clinical studies show that selenium is important in lowering the risk of several types of cancers. In combination with Vitamin E, selenium aids the production of antibodies and helps maintain a healthy heart. It also aids in the function of the pancreas, provides elasticity to tissues and helps cells defend themselves against damage from oxidation.
Vitamin C (Ascorbic Acid) A water-soluble antioxidant vitamin essential to the body's health. When bound to other nutrients, for example calcium, it would be referred to as "calcium ascorbate". As an antioxidant, it inhibits the formation of nitrosamines (a suspected carcinogen). Vitamin C is important for maintenance of bones, teeth, collagen and blood vessels (capillaries), enhances iron absorption and red blood cell formation, helps in the utilization of carbohydrates and synthesis of fats and proteins, aids in fighting bacterial infections, and interacts with other nutrients. It is present in citrus fruits, tomatoes, berries, potatoes and fresh, green leafy vegetables.
Vitamin E An essential fat-soluble vitamin. As an antioxidant, helps protect cell membranes, lipoproteins, fats and vitamin A from destructive oxidation. It helps protect red blood cells and is important for the proper function of nerves and muscles. For Vitamin E only, 1mg translates to 1 IU.
Zinc An essential trace mineral. The functions of zinc are enzymatic. There are over 70 metalloenzymes known to require zinc for their functions. The main biochemicals in which zinc has been found to be necessary include: enzymes and enzymatic function, protein synthesis and carbohydrate metabolism. Zinc is a constituent of insulin and male reproductive fluid. Zinc is necessary for the proper metabolism of alcohol, to get rid of the lactic acid that builds up in working muscles and to transfer it to the lungs. Zinc is involved in the health of the immune system, assists vitamin A utilization and is involved in the formation of bone and teeth.
Last updated: Sep 28, 2008
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