Spherocytosis

Definition of Spherocytosis:

A disease of the blood characterized by the production of red blood cells (erythrocytes), that are sphere-shaped, rather than donut-shaped.  It is caused by a molecular defect in one or more of the proteins of the red blood cell cytoskeleton.  Because the cell skeleton has a defect, the blood cell contracts to its most surface-tension efficient and least flexible configuration, a sphere, rather than the more flexible donut-shape.  The sphere-shaped red blood cells are known as spherocytes.

Also: Spherocytes

Topics Related to Spherocytosis

CBC (Complete Blood Count) Test

...as a treatment
“...Increased MCHC values (hyperchromia) are seen in conditions where the hemoglobin is abnormally concentrated inside the red cells, such as in hereditary spherocytosis, a relatively rare congenital disorder...”

Hemolytic Anemia

...the condition
“...Congenital Hemolytic Anemia is a general term for hemolytic anemia that is present from birth and in which the lifespan of red blood cells is diminished, such as occurs in hereditary spherocytosis.  Congenital Nonspherocytic Hemolytic Anemia includes any of a group of inherited anemias characterized by shortened red cell survival, lack of spherocytosis, and normal osmotic fragility...”

Hyperbaric Oxygen

...as a treatment
“...Upper respiratory infection – Increased hemolysis; Hyperthermia; Hereditary spherocytosis; Optic neuritis – Possible increased optic nerve pathology; Malignant tumors – possible increased vascularity for tumors; Acidosis – Decreased threshold for oxygen seizures; Steroid use...”
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