The fifth prostaglandin subtype discovered, and usually separated into PGE1 and PGE2. These two, if made by the kidneys, slow sodium reabsorption; if within the uterus, induce a stronger response from less stimulus; if made in the stomach lining inhibit gastric secretion; if secreted by macrophages, target tissues become more accessible to infiltration and inflammation. These are the two prostaglandins whose levels are meant to be stabilized by gamma-linolenic acid (GLA) supplements.
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