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Endometriosis
  Endometriosis
 Signs, symptoms, indicators
 Conditions that suggest it
 Contributing risk factors
 Conditions suggested by it
 Treatment recommendations
 Prevention
 


Endometriosis is a disease affecting many millions of women and teens worldwide and a leading cause of female health problems. This condition causes tissue such as the endometrium (the tissue inside the uterus which is shed each month during menses) to build up outside the lining of the uterus, or in other parts of the uterus or other areas of the body. These implants respond to hormonal commands each month, break down and then bleed. Unlike the endometrium, however, these tissue deposits have no way of leaving the body. The result is internal bleeding, degeneration of blood and tissue shed from the growths, inflammation of the surrounding areas, expression of irritating enzymes and formation of scar tissue. In addition, depending on the location of the growths, interference with the bowel, bladder, intestines and other areas of the pelvic cavity can occur. Endometriosis has even been found in the skin and at other extra-pelvic locations like the arms and legs, and even in the brain.

Signs & Symptoms


The symptoms can be very diverse depending on where the implant is located. Symptoms which seem to come and go with the menstrual cycle are suspicious. The implant responds to the same hormonal messages as other uterine tissue, swelling and changing during the cycle. Because symptoms are so inconsistent and non-specific, it can easily masquerade as several other conditions, including adenomyosis, appendicitis, ovarian cysts, bowel obstructions, colon cancer, diverticulitis, fibroid tumors, gonorrhea, inflammatory bowel disease, irritable bowel syndrome, ovarian cancer, and pelvic inflammatory disease. Pain tends to increase with time and begins progressively earlier in each successive menstrual cycle.

Diagnosis & Tests
Endometriosis is a notoriously difficult condition to diagnose, the conclusion often being reached only after excluding other problems. The presence of endometriosis can only be confirmed through examination of the tissue. Fiberoptic laparoscopic techniques allow a direct look at the problematic tissue. The average age at diagnosis is 37 years, and the majority of cases occur in women between the ages of 25 and 40. Endometriosis is rare before the onset of menstruation and after menopause but not unknown.

Treatment & Prevention
Contrary to common misconceptions about the disease, there is no cure. There are, however, several methods of treatment which may alleviate some of the pain and symptoms.





Signs, symptoms & indicators of Endometriosis:
Symptoms - Abdominal Pain  (Severe) abdominal discomfort
  Slight/intermittent/constant abdominal fullness

Symptoms - Bowel Movements

  (Frequent/significant) red blood in stools
  Regular/frequent/occasional painful urge to defecate

Symptoms - Gas-Int - General

  Meal-related bloating

Symptoms - General

  Fatigue induced by light exertion

Symptoms - Reproductive - General

  Painful deep penetration during sex
  (Possible) ectopic pregnancy

Conditions that suggest Endometriosis:
Pain  Low Back Pain

Symptoms - Reproductive - General

  Endometriosis (confirmed)

Uro-Genital

  Painful Menstruation (Dysmenorrhea)
 Endometriosis is the most common cause of menstrual cramps.

  Female Infertility
 It has been estimated that some 25-50% of infertile women suffer from endometriosis. The cause of infertility is believed to result from the scarring and adhesions that form in the reproductive tract as a result of inflammation. Scar tissue and adhesions may reduce fertility by either obstructing or distorting the shape of the fallopian tubes, which in turn impedes the passage of sperm to the egg. In the event that sperm do reach the egg, they may encounter a hostile environment unfavorable to fertilization. Finally, scarring from endometriosis may obstruct the fallopian tubes so that if an egg is fertilized, it may be unable to travel to the uterus for implantation.

  Susceptibility To Miscarriages
  Menorrhagia (Heavy Periods)
  Metrorrhagia
  Increased Urinary Frequency

Risk factors for Endometriosis:
Habits  Aerobic Exercise Need
 Endometriosis has been linked to a lack of physical activity.

Medical Procedures

Counter-indicators:
  Total/radical/partial hysterectomy or hysterectomy with both ovaries or hysterectomy with one ovary (confirmed)

Symptoms - Allergy

  History of adult allergies

Symptoms - Food - Preferences

  Partial vegetarian/omnivorous diet
 A study in July, 2004 showed that the consumption of meats -- particularly beef and pork -- was associated with a significantly increased risk of developing endometriosis.

Symptoms - Reproductive - General

  Normal age at/late birth of first child
 A first pregnancy at a young age seems to protect against its development; the disease is more common in women whose first pregnancy, if any, is later in life.


Counter-indicators:
  (Very) early birth of first child
 A first pregnancy at a young age seems to protect against its development; the disease is more common in women whose first pregnancy, if any, is later in life.

  (Several) successful pregnancies or a successful pregnancy
 Endometriosis often regresses during pregnancy.

Endometriosis suggests the following may be present:
Tumors, Malignant  Breast Cancer
 Endometriosis has been linked to the environmental contaminant dioxin and a lack of physical activity, both of which are also associated with an increased breast cancer risk.

  Ovarian Cancer
 Endometriosis has been linked to the environmental contaminant dioxin and a lack of physical activity, both of which are associated with an increased ovarian cancer risk.

  Melanoma
 Endometriosis has been linked to the environmental contaminant dioxin and a lack of physical activity, both of which are also associated with an increased risk of melanoma.

Recommendations and treatments for Endometriosis:
Botanical  Vitex / Chasteberry
 Vitex (as a hormone normalizer) may be considered the most appropriate of the herbal remedies for the underlying processes involved in endometriosis.

  Black Cohosh
 As a uterine tonic, it may help relieve symptoms.

Hormone

  Natural Progesterone
 Progesterone intravaginally can reduce the bleeding and pain associated with endometriosis.

Lab Tests/Rule-Outs

  Test for Hormones
 Estrogen excess or progesterone deficiency may contribute to the severity of the symptoms.

Surgery/Invasive

  Surgery
 Laser techniques to destroy endometrial tissue are currently popular in conventional medicine as is removing the uterus, ovaries (and perhaps appendix) thus stopping the menstrual cycle altogether.

Preventive measures against Endometriosis:
Diet  Plant-Based Nutrition
 A study in July, 2004 showed that consumption of fresh fruits and green vegetables was associated with decreased risk of developing endometriosis, and preventing re-occurrence.


KEY
Weak or unproven link
Strong or generally accepted link
Proven definite or direct link
Strongly counter-indicative
Very strongly or absolutely counter-indicative
May do some good
Likely to help
Highly recommended


GLOSSARY

Cancer
Refers to the various types of malignant neoplasms that contain cells growing out of control and invading adjacent tissues, which may metastasize to distant tissues.

Colon (Colonic)
The part of the large intestine that extends to the rectum. The colon takes the contents of the small intestine, moving them to the rectum by contracting.

Cramp (Cramping, Cramps)
A sudden, involuntary, painful muscular contraction.

Diverticular Disease (Diverticulitis, Diverticulosis)
Some people develop small pouches (diverticula) that bulge outward through weak spots in the colon. Diverticulosis is the condition of having these pouches; diverticulitis is an inflammation or infection in these pouches. The conditions diverticulosis and diverticulitis are both referred to as diverticular disease. Diverticulosis may not cause any symptoms but could include mild cramps, bloating and constipation - all of which are common to other conditions such as IBS or ulcers. The most common symptoms of diverticulitis are abdominal pain and tenderness around the left side of the lower abdomen. When infection is the cause, fever, nausea, vomiting, chills, cramping and constipation may also occur.

Endometriosis
A condition whereby endometrial tissue builds up in parts of the uterus where it does not belong or areas outside of the uterus, forming 'ectopic implants'. Unlike the normal tissue lining the uterus, ectopic tissue has no place to shed in response to a decline in estrogen and progesterone. This results in debris and blood accumulating at the site of the implant leading to inflammation, scarring and adhesions that ultimately cause symptoms and complications. Symptoms typically occur in a cyclic fashion with menstrual periods, the most common being pelvic pain and cramping before and during periods; pain during intercourse; inability to conceive; fatigue; painful urination during periods; gastrointestinal symptoms such as diarrhea, constipation, and nausea.

Enzymes (Enzyme)
Specific protein catalysts produced by the cells that are crucial in chemical reactions and in building up or synthesizing most compounds in the body. Each enzyme performs a specific function without itself being consumed. For example, the digestive enzyme amylase acts on carbohydrates in foods to break them down.

Estrogen (Oestrogen)
One of the female sex hormones produced by the ovaries.

Gonorrhea
A sexually-transmitted disease that is often without symptoms. If there are symptoms in the female, they include frequent and painful urination, cloudy vaginal discharge, vaginal itching, inflammation of the pelvic area, and abnormal uterine bleeding. If the male has a purulent (pus-like) urethral discharge, he should assume he has gonorrhea until proven otherwise.

Herbs (Herb, Herbal)
Herbs may be used as dried extracts (capsules, powders, teas), glycerites (glycerine extracts), or tinctures (alcohol extracts). Unless otherwise indicated, teas should be made with one teaspoon herb per cup of hot water. Steep covered 5 to 10 minutes for leaf or flowers, and 10 to 20 minutes for roots. Tinctures may be used singly or in combination as noted. The high doses of single herbs suggested may be best taken as dried extracts (in capsules), although tinctures (60 drops four times per day) and teas (4 to 6 cups per day) may also be used.

Hormones (Hormone)
Chemical substances secreted by a variety of body organs that are carried by the bloodstream and usually influence cells some distance from the source of production. Hormones signal certain enzymes to perform their functions and, in this way, regulate such body functions as blood sugar levels, insulin levels, the menstrual cycle, and growth. These can be prescription, over-the-counter, synthetic or natural agents. Examples include adrenal hormones such as corticosteroids and aldosterone; glucagon, growth hormone, insulin, testosterone, estrogens, progestins, progesterone, DHEA, melatonin, and thyroid hormones such as thyroxine and calcitonin.

Irritable Bowel Syndrome (IBS)
A condition that causes upset intestines for a long period of time. It is very unpleasant to the sufferer but tends to be harmless and usually does not lead to more serious complaints. The symptoms vary from person to person and from day to day. In order to be diagnosed with IBS, a person must have at least three of the following symptoms: pain in the lower abdomen; bloating; constipation; diarrhea or alternating diarrhea and constipation; nausea; loss of appetite; tummy rumbling; flatulence; mucous in stools; indigestion; constant tiredness; frequent urination; low back pain; painful intercourse for women.

Melanoma
A life-threatening type of skin cancer that occurs in the cells (melanocytes) that produce melanin, the pigment found in skin, hair, and the iris of the eyes.

Menopause (Menopausal)
The cessation of menstruation (usually not official until 12 months have passed without periods), occurring at the average age of 52. As commonly used, the word denotes the time of a woman's life, usually between the ages of 45 and 54, when periods cease and any symptoms of low estrogen levels persist, including hot flashes, insomnia, anxiety, mood swings, loss of libido and vaginal dryness. When these early menopausal symptoms subside, a woman becomes postmenopausal.

Menstruation (Menses, Menstrual, Menstrual Cycle, Menstrual Cycles, Menstrual Flow, Menstrual Phase, Monthly Cycle)
The periodic discharge of blood, tissue fluid and mucus from the endometrium (lining of the uterus) that usually lasts from 3 - 5 days. It is caused by a sudden reduction in estrogens and progesterone.

Ovarian Cysts (Ovarian Cyst)
These occur in two forms, namely "functional" and "organic". Symptoms may not be present but can include pressure or pain in the abdomen, problems with urine flow or pain during sexual intercourse. Rarely, a very large cyst can become twisted and stop its own blood supply, possibly causing nausea, fever or severe abdominal pain. Functional ovarian cysts form part of the normal functioning of the ovary and are always benign. They may be either "follicular cysts", produced by all menstruating women every month and reaching up to 2-3cm in diameter before they rupture at ovulation, or "corpus luteum cysts", which appear after ovulation and may grow to produce "hemorrhagic cysts" if ovulation does not occur or is delayed. Rupture of such a cyst can sometimes cause painful ovulation or bleeding, which is often moderate and resolves by itself. Organic ovarian cysts may be benign or malignant and are not linked to the functioning of the ovary. They occur as either "dermoid cysts", which are benign tumors that may nevertheless recur on either ovary and contain elements derived from the skin (hairs, sebum, teeth), or other organic cysts.

Ovary (Ovaries)
Ovaries are about the size of an almond and lie on either side of the lower abdomen beside the uterus. They usually produce one egg each month and whether the egg is fertilized or not, the reproductive process follows a monthly cycle, with constant changes in various hormone levels, preparing another opportunity for conception. The ovary is responsible for most of the estrogen production in women. At menopause (sometime after middle-age), egg production ceases and hormone levels drop significantly.

Pelvic Inflammatory Disease (PID, Salpingitis)
A purulent (pus-like) vaginal discharge with fever and lower abdominal pain. Salpingitis: Inflammation of the fallopian tubes.

Progesterone
This is the hormone secreted after ovulation by the corpus luteum. It is a steroid (similar to a cholesterol), enters receptive cells to stimulate their growth, and acts as an anabolic agent. Estrogen should be viewed as the primary coat underneath all the cycles during a woman's reproductive years, with progesterone, its antagonist, surging for ten or twelve days in ovulatory months. Most of the actions of progesterone cannot occur without estrogen having previously induced the growth of progesterone-receptive binding sites.

Scar Tissue
Fibrous tissue replacing normal tissues destroyed by injury or disease.

Uterus (Uterine)
The part of the female reproductive system specialized to allow the implantation, growth and nourishment of a fetus during pregnancy.

Vitex
Vitex agnus castus. Common name: chaste tree berry.




Last updated: Apr 13, 2008


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