What Causes Elevated Urine MMA Levels?
Elevated urine MMA levels can have various causes, just like most other symptoms. Finding the true cause means ruling out or confirming each possibility – in other words, diagnosis.
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Diagnosis is usually a complex process due to the sheer number of possible causes and related symptoms. In order to diagnose elevated urine MMA levels, we could:
- Research the topic
- Find a doctor with the time
- Use a diagnostic computer system.
The process is the same, whichever method is used.
Step 1: List all Possible Causes
We begin by identifying the disease conditions which have "elevated urine MMA levels" as a symptom. For example, vitamin B12 need.
Step 2: Build a Symptom Checklist
We then identify all possible symptoms and risk factors of each possible cause, and check the ones that apply:
frequent episodes of diarrhea
reduced sense of taste
tender calf muscles
some vitamin B12 supplementation
H2-blocker antacid use
very great unexplained weight loss
broad-spectrum antibiotic use
slight tongue swelling
slightly impaired ability to walk
macrocytic red cells
... and more than 10 others
Step 3: Rule Out or Confirm each Possible Cause
A differential diagnosis of your symptoms and risk factors finds the likely cause of elevated urine MMA levels.
Arriving at a Correct Diagnosis
is our online diagnosis tool that learns all about you through a straightforward process of multi-level questioning, providing diagnosis at the end.
Urine MMA. Normal levels are below 3.8ug of MMA per mg of creatinine (below 3.6umol MMA per mmol of creatinine); Elevated levels are anything above this.
→ Don't know
Based on your response to this question, which may indicate either normal urine MMA levels or elevated urine MMA levels, The Analyst™
will consider possibilities such as Vitamin B12 Requirement
. The UMMA test is a functional assay. UMMA reflects cobalamin (Vitamin B12) activity at the tissue/cellular level since MMA levels are directly related to a B12-dependent metabolic pathway. The conversion of MMA to succinic acid requires vitamin B12. The metabolic pathway is: MMA → (coenzyme B12 ) → succinic acid.
Vitamin B12 deficiency impedes this pathway and causes MMA levels to increase. Thus, as water builds up behind a dam, high UMMA levels indicate a vitamin B12 deficiency.
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