Pressure/Fullness Under Left Rib Cage

What Causes Pressure Under Left Rib Cage?

Pressure under left rib cage can have various causes, ranging in severity from 'troubling' to 'generally fatal'.  Finding the true cause means ruling out or confirming each possibility – in other words, diagnosis.

Diagnosis is usually a complex process due to the sheer number of possible causes and related symptoms.  In order to diagnose pressure under left rib cage, we could:
  • Research the topic
  • Find a doctor with the time
  • Use a diagnostic computer system.
The process is the same, whichever method is used.

Step 1: List all Possible Causes

We begin by identifying the disease conditions which have "pressure under left rib cage" as a symptom.  Here are eight possibilities (more below):
  • Hypersplenism
  • Sarcoidosis
  • Leukemia
  • Valley Fever (Coccidioidomycosis)
  • Enlarged Spleen
  • Congestive Heart Failure
  • Hemolytic Anemia
  • Infectious Mononucleosis

Step 2: Build a Symptom Checklist

We then identify all possible symptoms and risk factors of each possible cause, and check the ones that apply:
high sensitivity to bright light
constant fatigue
regular infections
loss of appetite
rapid pulse rate
much reduced sense of smell
very pale fingernails
multiple painful inguinal nodes
waking up with choking sensation
possible enlarged liver
long-term hoarse voice
shortness of breath when at rest
... and more than 70 others

Step 3: Rule Out or Confirm each Possible Cause

A differential diagnosis of your symptoms and risk factors finds the likely cause of pressure under left rib cage:
Cause Probability Status
Leukemia 92% Confirm
Hemolytic Anemia 15% Unlikely
Infectious Mononucleosis 17% Unlikely
Valley Fever (Coccidioidomycosis) 1% Ruled out
Hypersplenism 0% Ruled out
Enlarged Spleen 0% Ruled out
Congestive Heart Failure 0% Ruled out
Sarcoidosis 0% Ruled out
* This is a simple example to illustrate the process

Arriving at a Correct Diagnosis

The Analyst™ is our online diagnosis tool that learns all about you through a straightforward process of multi-level questioning, providing diagnosis at the end.

If you indicate abdominal pain, The Analyst™ will ask further questions including this one:
Have you noticed pressure or 'fullness' under your lower left rib cage, which is painless or slightly tender? (Do not answer this question if there is significant pain in this area because that is covered elsewhere.)
Possible responses:
→ Don't know / the pain is significant
→ No
→ Yes, slight pressure with no/slight pain
→ Yes, definite pressure with no/slight pain
Based on your response to this question, which may indicate either no pressure under left rib cage or pressure under left rib cage, The Analyst™ will consider possibilities such as:
Enlarged Spleen
Enlarged Spleen also suggests the following possibilities:
Congestive Heart Failure
In severe failure of the right ventricle, elevated venous pressures are transmitted to the portal system, leading to congestion of the spleen and splenomegaly.
Hypersplenism
Hypersplenism is sometimes referred to as enlarged spleen (splenomegaly), but in fact an enlarged spleen is one of the symptoms of hypersplenism.  What differentiates hypersplenism is its premature destruction of blood cells.
Infectious Mononucleosis - Mono
About 50-75% of people with mononucleosis have some spleen enlargement, usually seen two to three weeks after they first become sick.  Whether or not the spleen is enlarged, people who have mono should not lift heavy objects or exercise vigorously – especially participating in contact sports – for two months after they get sick, because these activities increase the risk of rupturing the spleen, which can be life-threatening.  If you have mono and get a severe sharp, sudden pain on the left side of your upper abdomen, go to an emergency room immediately.
Leukemia
ALL, CML, or hairy cell leukemia can cause enlargement of the spleen.