Abnormal lymphocyte count can have various causes, ranging in severity from 'minor' to 'generally fatal'. Finding the true cause means ruling out or confirming each possibility – in other words, diagnosis.
Diagnosis is usually a complex process due to the sheer number of possible causes and related symptoms. In order to diagnose abnormal lymphocyte count, we could:
|Whooping Cough||2%||Ruled out|
|Drug Side-Effects||0%||Ruled out|
|Splenectomy Side-Effects||0%||Ruled out|
White Blood Cells - Lymphocyte Percentage [fraction]
Possible responses:→ Don't know
→ Under 20% [0.20] (low)
→ 20 to 45% [0.20-0.45] (normal)
→ 46 to 55% [0.46-0.55] (elevated)
→ Over 55% [0.55] (high)
Certain drugs, such as mephenytoin, dilantin and para-aminosalicylic acid, can cause an increased lymphocyte count.
Lymphocytes are made in the bone marrow, so when the bone marrow isn't functioning properly, lymphocyte counts can drop.
Enlarged Spleen also suggests the following possibilities:
In severe failure of the right ventricle, elevated venous pressures are transmitted to the portal system, leading to congestion of the spleen and splenomegaly.
Hypersplenism is sometimes referred to as enlarged spleen (splenomegaly), but in fact an enlarged spleen is one of the symptoms of hypersplenism. What differentiates hypersplenism is its premature destruction of blood cells.
About 50-75% of people with mononucleosis have some spleen enlargement, usually seen two to three weeks after they first become sick. Whether or not the spleen is enlarged, people who have mono should not lift heavy objects or exercise vigorously – especially participating in contact sports – for two months after they get sick, because these activities increase the risk of rupturing the spleen, which can be life-threatening. If you have mono and get a severe sharp, sudden pain on the left side of your upper abdomen, go to an emergency room immediately.
ALL, CML, or hairy cell leukemia can cause enlargement of the spleen.
Autoimmune problems such as rheumatoid arthritis can cause reduced lymphocyte counts.
A complete blood count may show large numbers of lymphocytes in a pertussis patient.