Whole blood manganese levels are considered to be a reliable measure of body manganese. Hair manganese levels also correlate well with manganese levels in other body tissues, but dark hair dyes can contain manganese and thus falsely elevate readings. In the case of extremely high manganese levels obtained from scalp hair, pubic hair should be tested as a control. Low hair manganese levels are considered reliable.
Sohler (1979) compared blood manganese (Mn) levels in a group of patients with seizure activity to those in a control group. Blood Mn levels from control subjects had a mean of 14.8ng/gm (ppb). The blood Mn levels were significantly lower in the patients with seizure activity, at 9.9 +/- 4.9ng/gm, p < 0.005). In uncontrolled trials several doctors found that Mn is helpful in controlling seizures of both minor and major types.
In one case report, a twelve-year-old boy with poorly controlled epilepsy experienced a reduction in seizure frequency after receiving 20mg per day of manganese. Although this research is encouraging, it must still be considered preliminary.