This information regarding Naltrexone is being presented here because of its potential importance to seriously ill individuals and its record of safety.
Dr. Bernard Bihari, MD pioneered the use of Low Dose Naltrexone (LDN) in 1985.
Function; Why it is Recommended
By blocking opioid receptors, naltrexone also blocks the reception of the opioid hormones (endorphins
) that the brain and adrenal glands
produce. Many body tissues have receptors for the endorphins, including virtually every cell of the body's immune system.
Naltrexone is usually used in 50mg doses as a drug to help heroin or opium addicts, by blocking the effect of such drugs. FDA-approved naltrexone, in a low dose (only 3mg), can boost the immune system, helping those with HIV
, cancer, and autoimmune
diseases. LDN is currently under experimental use for many conditions. Preliminary results are very encouraging: Naltrexone increases the body's production of the beta and metenkephalin endorphins
and blood tests have indicated that it can double or even triple the activity of natural killer cells. The web site that presents the current available information on this therapy can be accessed by clicking here
The following diseases have been benefited by LDN use according to Dr. Bernard Bihari, MD.:
How is it possible that one medication can impact such a wide range of disorders? The disorders listed above all share a particular feature: the immune system plays a central role in all of them. Indeed, research by others has found opioid (endorphin
) receptors in brain tumors
(both astrocytoma and glioblastoma), breast cancer, endometrial cancer, head and neck squamous cell carcinoma
, myeloid leukemia, lung
cancer (both small cell and non- small cell), and in neuroblastoma. These findings suggest the possibility for a beneficial effect in a wide variety of other cancers.
The brief blockade of opioid (endorphin) receptors that is caused by taking LDN at bedtime each night is believed to produce a prolonged improvement in vital elements of the immune system by causing an increase in endorphin production. Normal volunteers who have taken LDN in this fashion have been found to have much higher levels of beta-endorphins circulating in their blood in the following days.
The treatment seems to work by causing the body to secrete endorphins
(metenkephalin and beta-endorphin) which attach to cancers having opiate receptors, shrinking the tumors
and inhibiting their growth. When metenkephalin and/or beta-endorphins are attached to cancer cells while they are dividing, it seems to stimulate a process of programmed cell death or apoptosis
, thus killing some cancer cells. In addition, it is believed that the endorphins act to increase natural killer cells and other healthy immune defenses against cancer.
LDN comes in 3mg capsules and is taken once a day at bedtime.
LDN is non-toxic and has no side-effects. Its only interaction with other drugs is with narcotics
(such as morphine, Demerol and Percocet), which it briefly blocks.