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Pantethine
  Pantethine
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Pantethine is the stable (dimer) form of pantetheine, the active form of pantothenic acid, which in turn is the basic component of coenzyme A (CoA). Among other things, the transport and catabolism of fatty acids is dependent on CoA. Because of this activity, pantethine has been shown in clinical trials to reduce serum cholesterol and triglycerides. Pantethine is also thought to inhibit cholesterol synthesis. Pantethine, the concentration of which is reduced during decreased oxygen supply to the heart, may also be indicated for angina. Pantethine is listed as an antihyperlipoproteinemic in the Merck index.





Pantethine can help with the following:
Circulation  Angina
 Heart pantethine levels decrease during times of reduced oxygen supply. Demonstrated effects in animals indicate that it would be beneficial to individuals with angina. The typical dose is 900mg per day.

  Congestive Heart Failure


KEY
Likely to help


GLOSSARY

Angina
Angina Pectoris: Severe, restricting chest pain with sensations of suffocation caused by temporary reduction of oxygen to the heart muscle through narrowed diseased coronary arteries. Often triggered by exertion. Angina Vasomotoria: Like the previous, but less dangerous and more frequently caused by purely neurologic stimulus. The pain is more spasmodic and there is usually little actual blood vessel blockage.

Cholesterol
A waxy, fat-like substance manufactured in the liver and found in all tissues, it facilitates the transport and absorption of fatty acids. In foods, only animal products contain cholesterol. An excess of cholesterol in the bloodstream can contribute to the development of atherosclerosis.

Coenzyme
A heat stable molecule that must be associated with another enzyme for the enzyme to perform its function in the body. It is necessary in the utilization of vitamins and minerals.

Fatty Acids (Fatty Acid)
Chemical chains of carbon, hydrogen, and oxygen atoms that are part of a fat (lipid) and are the major component of triglycerides. Depending on the number and arrangement of these atoms, fatty acids are classified as either saturated, polyunsaturated, or monounsaturated. They are nutritional substances found in nature which include cholesterol, prostaglandins, and stearic, palmitic, linoleic, linolenic, eicosapentanoic (EPA), and decohexanoic acids. Important nutritional lipids include lecithin, choline, gamma-linoleic acid, and inositol.

Milligram (mg, Milligrams)
0.001 or a thousandth of a gram.

Pantothenic Acid
A B-complex vitamin necessary for the normal functioning of the adrenal gland, which directly affects growth. It is also essential for the formation of fatty acids. As a coenzyme, it participates in the utilization of riboflavin and in the release of energy from carbohydrates, fats and proteins.

Serum
The cell-free fluid of the bloodstream. It appears in a test tube after the blood clots and is often used in expressions relating to the levels of certain compounds in the blood stream.

Triglyceride (Triglycerides)
The main form of fat found in foods and the human body. Containing three fatty acids and one unit of glycerol, triglycerides are stored in adipose cells in the body, which, when broken down, release fatty acids into the blood. Triglycerides are fat storage molecules and are the major lipid component of the diet.




Last updated: Apr 13, 2008


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