The root of Stillingia sylvatica was official in the USP until 1926 and in the National Formulary until 1947. Stillingia, also known as yaw root or queen's root, was considered an alternative (cure for syphilis) by many of the eclectic physicians in the 19th century. Stillingia root contains tannins, gums, starches, and volatile oils among other minor constituents. In small doses, stillingia is thought to exert a stimulatory action on the lymphatic and secretory systems. Stillingia is still added to formulas used for the cleansing of the lymph and blood systems.

In larger doses, stillingia can act as an emetic (induce vomiting) and laxative. Stillingia is a rare addition to current formulations, although herbalist in the south-eastern United States often find uses for it with their patients.