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Topical Estrogen
  Estrogen, Topical
 Recommended for…
 


Estrogens are a class of hormones produced in the ovaries, or made from other hormones in fat cells. There are three estrogens: estradiol, estratiol and estrone. These natural hormones work more efficiently compared to synthetic estrogens or, even worse, animal estrogens. The most common (though cruelly-produced) animal product is Conjugated Equine Estrogens (Premarin). The proper dose is titrated against the pituitary hormones of LH and FSH. These are prescription drugs, but soy products can act as a surrogate for estrogen. Although estrogen may be good for men, according to studies, it is generally recommended only to women. Using estrogen alone in women, with their uterus still present, could, in a few percent, cause cancer of that organ.





Topical Estrogen can help with the following:
Circulation  Poor/Slow Wound Healing
 Complications are more likely to develop in aging skin, such as the progression of a wound to a chronic non-healing state. This is related to an increased amount of elastase in the wound. Elastase is an enzyme that breaks down elastic proteins and is upregulated in impaired wound healing states. In a study [Ashcroft et al. 1999] involving 36 patients over the age of 70, half male and half female, topical estrogen was found to decrease delays in wound healing in both the male and female patients. Wound size, collagen levels, and fibronectin levels all improved with topical estrogen, indicating improved wound healing. In this study, estrogen was delivered to the wound site for 24 hours as a patch routinely used in female estrogen replacement therapy. Fibronectin levels have been found to be deficient in chronic wounds of the aged, such as venous ulcers in humans or laboratory wounds in aged animals [Herrick et al. 1997].

Uro-Genital

Not recommended for:
  Pregnancy-Related Issues
 There are essentially no reasons during pregnancy why any woman would be advised to take hormones.


KEY
May do some good
Avoid absolutely


GLOSSARY

Cancer
Refers to the various types of malignant neoplasms that contain cells growing out of control and invading adjacent tissues, which may metastasize to distant tissues.

Chronic (Chronicity)
Usually referring to chronic illness: Illness extending over a long period of time.

Collagen
The primary protein within white fibers of connective tissue and the organic substance found in tendons, ligaments, cartilage, skin, teeth and bone.

Enzymes (Enzyme)
Specific protein catalysts produced by the cells that are crucial in chemical reactions and in building up or synthesizing most compounds in the body. Each enzyme performs a specific function without itself being consumed. For example, the digestive enzyme amylase acts on carbohydrates in foods to break them down.

Estrogen (Oestrogen)
One of the female sex hormones produced by the ovaries.

Hormones (Hormone)
Chemical substances secreted by a variety of body organs that are carried by the bloodstream and usually influence cells some distance from the source of production. Hormones signal certain enzymes to perform their functions and, in this way, regulate such body functions as blood sugar levels, insulin levels, the menstrual cycle, and growth. These can be prescription, over-the-counter, synthetic or natural agents. Examples include adrenal hormones such as corticosteroids and aldosterone; glucagon, growth hormone, insulin, testosterone, estrogens, progestins, progesterone, DHEA, melatonin, and thyroid hormones such as thyroxine and calcitonin.

Ovary (Ovaries)
Ovaries are about the size of an almond and lie on either side of the lower abdomen beside the uterus. They usually produce one egg each month and whether the egg is fertilized or not, the reproductive process follows a monthly cycle, with constant changes in various hormone levels, preparing another opportunity for conception. The ovary is responsible for most of the estrogen production in women. At menopause (sometime after middle-age), egg production ceases and hormone levels drop significantly.

Pituitary (Pituitary Gland)
The pituitary gland is a small (half-inch), bean-shaped organ that hangs down from the lower center of the brain on a stalk attached to another gland, the hypothalamus. Weighing less than one gram, the pituitary gland is often called the "master gland" since it controls the secretion of hormones by other endocrine glands. It regulates many body activities, and is partitioned into front and back lobes. The front lobe is stimulated by the hypothalamus, and produces any one of six different hormones that in turn stimulate the thyroid, adrenal and reproductive glands, and also breast milk production.

Protein (Proteins)
Compounds composed of hydrogen, oxygen, and nitrogen present in the body and in foods that form complex combinations of amino acids. Protein is essential for life and is used for growth and repair. Foods that supply the body with protein include animal products, grains, legumes, and vegetables. Proteins from animal sources contain the essential amino acids. Proteins are changed to amino acids in the body.

Topical
Most commonly 'topical application': Administration to the skin.

Ulcer (Ulceration, Ulcers)
Lesion on the skin or mucous membrane.

Uterus (Uterine)
The part of the female reproductive system specialized to allow the implantation, growth and nourishment of a fetus during pregnancy.

Venous
Pertaining to the veins.




Last updated: Sep 28, 2008


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