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Conjugated Linoleic Acid (CLA) is a potent antioxidant, immune stimulant, and anticancer agent in all species of animals tested. It has also been found to 'repartition' their bodies, decreasing fat and increasing lean body mass. At least one human study confirms these results, with other studies underway.
Source
CLA is a natural fatty acid found in beef, lamb, turkey and cheese. Most Americans consume only 1gm of conjugated linoleic acid per day. Whole milk usually contains 2mg per gram of fat but can be increased by feeding cows corn oil.
Function
Preliminary studies in rat models showed that Conjugated Linoleic Acid has a powerful anticarcinogenic effect against mammary tumors. CLA may have a direct effect by reducing the cancer risk of the target organ. It is noted that, unlike CLA, most anticarcinogenic substances come from plant sources.
Cow's Milk - CLA appears to have an antiproliferative effect on human malignancy. In vitro studies have shown that the milk phospholipid, sphingomyelin, affects three different major antiproliferative pathways which influence oncogenesis. These pathways are inhibition of cell growth, induction of differentiation, and apoptosis.
One-third of all milk triglycerides contain one molecule of butyric acid, which is a potent inhibitor of proliferation and inducer of differentiation and apoptosis in a wide range of neoplastic lines. An animal study suggests that dietary butyrate may also inhibit mammary tumorigenesis, as well as being an important colon cancer protective agent.
Directions
Dose: 1 to 3gm per day is a normal dose for healthy people. A 70kg individual (154 pounds) would need to consume 3.5gm of CLA daily to receive benefit.
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CLA (Conjugated Linoleic Acid) can help with the following:
KEY | | May do some good |  | | Likely to help |  | | Avoid absolutely |
GLOSSARY
Antioxidant (Antioxidants)
A chemical compound that slows or prevents oxygen from reacting with other compounds. Antioxidants are substances that protect cells from oxidative damage caused by molecules called free radicals. These chemicals can damage important parts of cells, such as proteins, membranes, and DNA. Some antioxidants have been shown to have cancer-protecting potential because they neutralize free radicals. Examples include vitamins C and E, beta carotene, the minerals selenium and germanium, superoxide dismutase (SOD), coenzyme Q10, catalase, and some amino acids.
Apoptosis
Programmed cell death as signaled by the nuclei in normally functioning human and animal cells when age or state of cell health and condition dictates. Cancerous cells, however, are unable to experience the normal cell transduction or apoptosis-driven natural cell death process.
Butyrate
Butyrate is an important short chain fatty acid that provides fuel for colon cells and may help protect against colon cancer. The most potent dietary source is butter (3%).
Cancer
Refers to the various types of malignant neoplasms that contain cells growing out of control and invading adjacent tissues, which may metastasize to distant tissues.
Colon (Colonic)
The part of the large intestine that extends to the rectum. The colon takes the contents of the small intestine, moving them to the rectum by contracting.
Fatty Acids (Fatty Acid)
Chemical chains of carbon, hydrogen, and oxygen atoms that are part of a fat (lipid) and are the major component of triglycerides. Depending on the number and arrangement of these atoms, fatty acids are classified as either saturated, polyunsaturated, or monounsaturated. They are nutritional substances found in nature which include cholesterol, prostaglandins, and stearic, palmitic, linoleic, linolenic, eicosapentanoic (EPA), and decohexanoic acids. Important nutritional lipids include lecithin, choline, gamma-linoleic acid, and inositol.
Gram (gm, gms, Gramme, Grammes, Grams)
A metric unit of weight, there being approximately 28 grams in one ounce.
Kilogram (kg, kgs, Kilogramme, Kilogrammes, Kilograms)
1000 grams, 2.2lbs.
Milligram (mg, Milligrams)
0.001 or a thousandth of a gram.
Phospholipid
A fat or lipid containing phosphorus found in high quantities in the brain and very important to the function of cellular membranes and to the nervous system.
Triglyceride (Triglycerides)
The main form of fat found in foods and the human body. Containing three fatty acids and one unit of glycerol, triglycerides are stored in adipose cells in the body, which, when broken down, release fatty acids into the blood. Triglycerides are fat storage molecules and are the major lipid component of the diet.
Last updated: Nov 07, 2008
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