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Human Growth Hormone (HGH)
 


HGH is tauted by some as the elixir of youth of the 21st century. Its "legitimate" use is for pituitary-related child dwarfism, although an article in The Lancet gave credence to claims that it will render congenitally short-statured children into normal size adults. History; Source


First discovered in 1921, HGH was isolated in 1956 and over the ensuing three decades its 191 amino acid sequence has been worked out, first by Genentech in 1986 and later by several other drug companies using recombiant DNA techniques.

Bio-engineered growth hormone can be produced in vast quantities by special bacteria or by mamalian cells. Previously, it had to be harvested form cadavers and was abandoned in 1987, because of a contaminating virus causing disease in the recipient similar to Mad Cow Disease, CJD.

Function
The physiology of HGH is complex and the decline in production is age-related. It is secreted by the pituitary gland and causes growth and repair of the body's tissue through several mediations such as IGF-1.





GLOSSARY

Amino Acid (Amino Acids)
An organic acid containing nitrogen chemical building blocks that aid in the production of protein in the body. Eight of the twenty-two known amino acids are considered "essential," and must be obtained from dietary sources because the body can not synthesize them.

Bacteria (Bacterial, Bacterium)
Microscopic germs. Some bacteria are "harmful" and can cause disease, while other "friendly" bacteria protect the body from harmful invading organisms.

DNA
Deoxyribonucleic acid, the large molecule that is the main carrier of genetic information in cells. DNA is found mainly in the chromosomes of cells.

Hormones (Hormone)
Chemical substances secreted by a variety of body organs that are carried by the bloodstream and usually influence cells some distance from the source of production. Hormones signal certain enzymes to perform their functions and, in this way, regulate such body functions as blood sugar levels, insulin levels, the menstrual cycle, and growth. These can be prescription, over-the-counter, synthetic or natural agents. Examples include adrenal hormones such as corticosteroids and aldosterone; glucagon, growth hormone, insulin, testosterone, estrogens, progestins, progesterone, DHEA, melatonin, and thyroid hormones such as thyroxine and calcitonin.

IGF-1
Insulin-like growth factor.

Pituitary (Pituitary Gland)
The pituitary gland is a small (half-inch), bean-shaped organ that hangs down from the lower center of the brain on a stalk attached to another gland, the hypothalamus. Weighing less than one gram, the pituitary gland is often called the "master gland" since it controls the secretion of hormones by other endocrine glands. It regulates many body activities, and is partitioned into front and back lobes. The front lobe is stimulated by the hypothalamus, and produces any one of six different hormones that in turn stimulate the thyroid, adrenal and reproductive glands, and also breast milk production.

Virus (Viri, Viruses)
Any of a vast group of minute structures composed of a protein coat and a core of DNA and/or RNA that reproduces in the cells of the infected host. Capable of infecting all animals and plants, causing devastating disease in immunocompromised individuals. Viruses are not affected by antibiotics, and are completely dependent upon the cells of the infected host for the ability to reproduce.




Last updated: Apr 13, 2008


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