Vitamin A Toxicity

Vitamin A Toxicity: Overview

This is a potentially serious problem.  It usually occurs by taking more that 50,000-250,000 IU per day for more than 3 months.  It can lead to dry skin, mouth sores, vomiting, and poor appetite.  Eventually, it can cause increased pressure within the brain, headaches, and problems thinking clearly.  It may also lead to an enlarged liver or to liver failure. Vitamin A is normally a fat-soluble vitamin.  It occurs in nature as preformed vitamin A and provitamin A (primarily beta carotene).  The carotenes are converted into vitamin A in the intestines.  Fat-soluble vitamin A can accumulate in the liver, causing side-effects, but consuming too much carotene will not result in vitamin A toxicity.  Thyroxine, zinc and vitamin E enhance the conversion of carotene to vitamin A.  Water-soluble vitamin A results in higher blood levels, with less accumulation in the liver, and, though hard to find, can be used safely in much higher doses.

Laboratory tests appear unreliable for monitoring toxicity, since serum vitamin A levels correlate poorly with toxicity, and SGOT and SGPT are elevated only in symptomatic patients.  More importantly, there is concern about the teratogenicity of massive dosages of vitamin A.  Women of child-bearing age should use effective birth control during treatment and for at least one month after discontinuation.

Some may take too much vitamin A at once, absorbed via overdose (or by doing something stupid such as eating polar bear liver!) This can cause stomach pain, nausea, vomiting, headache, and difficulty sleeping.

Signs and Symptoms

Chapped lips and dry skin, which may be early symptoms, will generally occur in the majority of patients, particularly in dry weather.  The first significant toxic symptom is usually headache followed by fatigue, emotional lability, and muscle and joint pain.

Signs, symptoms & indicators of Vitamin A Toxicity:

Symptoms - General

Symptoms - Head - Mouth/Oral

Chapped lips may be a sign or symptom of Vitamin A Toxicity Chapped lips

Chapped lips and dry skin, which may be early symptoms, will generally occur in the majority of patients, particularly in dry weather.

Symptoms - Mind - Emotional

Symptoms - Skeletal

Conditions that suggest Vitamin A Toxicity:

Metabolic

Musculo-Skeletal

Skin-Hair-Nails

Dry skin may suggest Vitamin A Toxicity Dry skin

Chapped lips and dry skin, which may be early symptoms, will occur in a majority of patients with vitamin A toxicity, particularly in dry weather.

Male Hair Loss may suggest Vitamin A Toxicity Male Hair Loss

Vitamin A toxicity symptoms include skin that has a rough and dry appearance, hair loss and brittle nails.

Female Hair Loss may suggest Vitamin A Toxicity Female Hair Loss

Vitamin A toxicity symptoms include skin that has a rough and dry appearance, hair loss and brittle nails.

Vitamin A Toxicity can lead to:

Metabolic

Skin-Hair-Nails

Vitamin A Toxicity usually leads to Dry skin Dry skin

Chapped lips and dry skin, which may be early symptoms, will occur in a majority of patients with vitamin A toxicity, particularly in dry weather.

Vitamin A Toxicity often leads to Male Hair Loss Male Hair Loss

Vitamin A toxicity symptoms include skin that has a rough and dry appearance, hair loss and brittle nails.

Vitamin A Toxicity often leads to Female Hair Loss Female Hair Loss

Vitamin A toxicity symptoms include skin that has a rough and dry appearance, hair loss and brittle nails.

Recommendations for Vitamin A Toxicity:

Vitamins

Not recommended
Vitamin A is NOT recommended for Vitamin A Toxicity Vitamin A

The (obvious) treatment is to stop taking vitamin A immediately.  The symptoms usually improve in a few days.

KEY

Weak or unproven link: may be a sign or symptom of; may suggest
Weak or unproven link:
may be a sign or symptom of; may suggest
Strong or generally accepted link: often leads to
Strong or generally accepted link:
often leads to
Definite or direct link: usually leads to
Definite or direct link:
usually leads to
Should be avoided: is NOT recommended for
Should be avoided:
is NOT recommended for