Vasculitis

Vasculitis: Overview

Vasculitis is an inflammation of the blood vessels.  It is commonly associated with diseases such as SLE, scleroderma, ulcerative colitis, rheumatoid arthritis and dermatomyositis. Immune complexes are formed when antigens bind to antibodies.  If not excessive, and assuming a healthy immune response, these complexes are usually cleared from the circulation by the phagocytic system.  These responses are usually delayed, occurring hours or even days after exposure to the antigen, from whatever source.  When these complexes persist in the circulation, their interaction with platelets results in the release of vasoactive amines.  Vasoactive amines cause increased vessel permeability, platelet aggregation (clotting) and initiation of the arachidonic acid cascade (inflammation).  These immune complexes can also settle out within the postcapillary venules, with subsequent tissue inflammation, irritation and damage by complement activation, more inflammatory cells coming to the area and destructive lysosomal enzyme release.

Liver diseases such as chronic hepatitis, alcoholic cirrhosis and biliary cirrhosis are associated with lowered hepatic clearance and increased circulating immune complexes.

Causes and Development

Drugs, complement deficiencies, viral, bacterial and protozoan infections have all been implicated.

Signs and Symptoms

Vasculitis can cause many different symptoms, depending upon what tissues are involved and the severity of the tissue damage.  Some patients are not ill and only notice occasional spots on their skin.  Others are very ill with systemic symptoms and major organ damage.  A list of symptoms based on the tissues in which vasculitis occurs include:
  • Systemic symptoms
    Fever, generally feeling bad ("malaise"), muscle and joint pain, poor appetite, weight loss and fatigue.  This set of complaints can occur in many illnesses and is not specific to vasculitis.
  • Skin
    Red or purple dots ("petechiae"), usually most numerous on the legs.  When the spots are larger, about the size of the end of a finger, they are called "purpura".  Some look like large bruises.  These are the most common vasculitis skin lesions, but hives, an itchy lumpy rash, and painful or tender lumps can occur.  Areas of dead skin can appear as ulcers (especially around the ankles), small black spots at the ends of the fingers or around the fingernails and toes ("nail fold infarcts"), or gangrene of fingers or toes.
  • Joints
    Aching in joints and a frank arthritis with pain, swelling and heat in joins.  Deformities resulting from this arthritis are rare.
  • Brain
    Vasculitis in the brain can cause many problems, from mild to severe.  They include headaches, behavioral disturbances, confusion, seizures and strokes.
  • Peripheral Nerves
    Peripheral nerve symptoms may include numbness and tingling (usually in an arm or a leg, or in areas which would be covered by gloves or socks), loss of sensation or loss of strength (especially in the feet or hands).
  • Intestines
    Inadequate blood flow in the intestines can cause crampy abdominal pain and bloating.  If areas in the wall of the intestine develop gangrene, blood will appear in the stool.  If the intestinal wall develops a hole (called a "perforation"), surgery may be required.
  • Heart
    Vasculitis in the coronary arteries is unusual in lupus.  If it occurs, it can cause a feeling of heaviness in the chest during exertion ("angina"), which is relieved by rest.  Heart attacks rarely occur as a result of vasculitis.
  • Lungs
    Vasculitis in this tissue can cause pneumonia-like attacks with chest X-ray changes that look like pneumonia, and symptoms of fever and cough.  Inflammation can occasionally lead to scarring of lung tissue with chronic shortness of breath.
  • Kidneys
    Vasculitis is not common in kidneys of people with lupus, even those who have lupus nephritis.  It may not cause any symptoms, although most patients with renal vasculitis have high blood pressure.
  • Eyes
    Vasculitis involving the small blood vessels of the retina can occur in cases of lupus.  The retina is a tissue at the back of the eye which contains cells that have to be activated to form a visual image.  Vasculitis of the eyes occasionally causes no symptoms but usually there is visual blurring which comes on suddenly and stays, or a person may even lose a portion of their vision.  In other non-lupus types of vasculitis, such as temporal arteritis, there is sudden loss of part or all of the vision in one eye, usually accompanied by sever headache.

Treatment and Prevention

Treatment revolves around the removal or reduction of circulating immune complexes, dampening down the inflammatory response, stabilising lysosomal cell membranes and improving circulation to damaged tissues.

Sometimes drugs, hidden infections and food allergens increase the level of circulating immune complexes.  Exposure to these should be reduced.  Avoid temperature extremes, as cold can precipitate immune complexes.

Vasculitis

Information On This Page

Signs, symptoms & indicators of Vasculitis:

Lab Values - Cells

Conditions that suggest Vasculitis:

Symptoms - Cardiovascular

Risk factors for Vasculitis:

Autoimmune

Lupus, SLE may increase risk of VasculitisLupus, SLE (Systemic Lupus Erythromatosis)
In the vasculitis caused by lupus, the antigens causing the immune complexes are often not known.  In some cases, the complexes contain DNA and anti-DNA antigens, or Ro (also called SS-A) and anti-Ro antigens.  Another antibody, ANCA (anti-neutrophil cytoplasm antibody), can cause vasculitis in some individuals.

Recommendations for Vasculitis:

Digestion

Digestive Enzymes often helps with VasculitisDigestive Enzymes
Decreasing circulating immune complexes may be accelerated by breaking them down with the use of trypsin, chymotrypsin and pancreatin.  These enzymes must be given at least one hour before meals.  One of the basic concepts in systemic enzyme therapy is that all kinds of inflammatory processes respond to enzymes.  Hydrolytic enzymes directly attack the microclots breaking open the clogged vessels and reestablishing circulation.  By restoring normal blood flow, post inflammatory pain and edema are reduced more rapidly.

Nutrient

Essential Fatty Acids may help with VasculitisEssential Fatty Acids
An essential fatty acid Omega-6/Omega-3 imbalance or deficiency can contribute to inflammation, which is part of the problem in vasculitis.

Vitamins

Vitamin E may help with VasculitisVitamin E
A membrane's lipid bilayers are high in polyunsaturated fatty acids which are subject to oxidation.  Vitamin E's function in maintaining membrane integrity might be attributed to its prevention of the membrane damage.  It has been hypothesized vitamin E protects the lysosomal membranes from rupturing and destroying the cells.
Bioflavonoids may help with VasculitisBioflavonoids
Due to its antioxidant effect, quercetin can inhibit inflammatory processes mediated by "leukotrienes" (inflammatory agents a thousand times more powerful than histamines), hyaluronidase (collagen-destroying enzymes), and lysosomal enzymes (other promoters of localized inflammation.)

KEY

Weak or unproven link: may be a sign or symptom of; may increase risk of
Weak or unproven link:
may be a sign or symptom of; may increase risk of
Definite or direct link: strongly suggests
Definite or direct link:
strongly suggests
May be useful: may help with
May be useful:
may help with
Moderately useful: often helps with
Moderately useful:
often helps with