Progesterone Excess

Progesterone Excess: Overview

Progesterone, like all hormones, needs to be in balance to ensure proper health.  Progesterone is naturally produced during the second week of a woman's period, but her ovaries may produce it in excess. A woman's body produces progesterone to prepare the lining of the uterus to accept a fertilized egg.  When no egg is fertilized, progestin levels fall and the lining is shed, which is what produces menstruation.

Progesterone is a member of a group of hormones known as progestogens or progestins (the exogenous or synthetic versions.) These can be found in birth-control pills, in hormones given during menopause for replacement therapy, or in medications to correct abnormal bleeding problems during menses.  These hormones are also used to counteract PMS syndrome, infertility, and pregnancy loss.  Many women are aware of the effects of too little or too much estrogen, but have never looked up progesterone side-effects.

Causes and Development

Progesterone levels rise during pregnancy and fall when menstruation begins.  High progesterone levels will be present when a woman is having a multiple birth – twins, triplets, etc.  – or sometimes in cases of luteal ovarian cysts, molar pregnancies, and some forms of ovarian cancer.

Signs and Symptoms

If a woman has too much progesterone she will suffer from a series of side-effects including fatigue, breast tenderness, bloating, mood swings, sedation, loss of libido, and vaginal dryness.

Approximately 30-40% of menopausal women who take progesterone experience unpleasant PMS-like symptoms such as moodiness, irritably, and muscle aches.  Individuals who have had significant premenstrual symptoms while they were premenopausal are more likely to be affected.

Treatment and Prevention

Some women respond to even very low doses of progesterone with symptoms of excess.  This is not so much an excess susceptibility as an indication that these women's endogenous production is adequate to provide for their needs.  In practice, the range of progesterone tolerance can be quite narrow, and a tiny dose is all that is needed to complete the balance between the estrogens and progesterone.

Progestins produce moodiness and irritability by affecting specific sites in the brain.  Changing the type of progesterone, the dose, the route of administration and the length of treatment can lessen this effect.

Signs, symptoms & indicators of Progesterone Excess:

Lab Values - Hormones

Symptoms - Mind - Emotional

Symptoms - Reproductive - Female Cycle

Symptoms - Sleep

Conditions that suggest Progesterone Excess:

Hormones

Infections

Urinary Tract Infection (UTI) may suggest Progesterone Excess Urinary Tract Infection (UTI)

One mysterious effect in the progesterone intolerant women is bladder problems.  Some women have either a great increase in urinary tract infections or a feeling like they are having an infection as soon as they try taking a "normal" progesterone dose.  If bladder symptoms start and stop with starting and stopping progesterone, they may be related.

Symptoms - Immune System

Risk factors for Progesterone Excess:

Supplements and Medications

Taking excesssive oral progesterone increases risk of Progesterone Excess On normal dose/taking excesssive oral progesterone

Progesterone in high doses can cause side-effects.  In one study, oral micronized progesterone at a dose of 400mg per day was associated with dizziness, abdominal cramping, headache, breast pain, muscle pain, irritability, nausea, fatigue, diarrhea and viral infections.[Medical Economics; 1999: p.125]

Symptoms - Immune System

Symptoms - Reproductive - General

Counter-indicators

Progesterone Excess can lead to:

Hormones

Recommendations for Progesterone Excess:

Hormone

Not recommended

Lab Tests/Rule-Outs

KEY

Weak or unproven link: may be a sign or symptom of; may suggest; may increase risk of
Weak or unproven link:
may be a sign or symptom of; may suggest; may increase risk of
Strong or generally accepted link: often suggests; often increases risk of; often leads to
Strong or generally accepted link:
often suggests; often increases risk of; often leads to
Definite or direct link: is a sign or symptom of; increases risk of
Definite or direct link:
is a sign or symptom of; increases risk of
Definitely or absolutely counter-indicates: decreases risk of
Definitely or absolutely counter-indicates:
decreases risk of
Very useful: is highly recommended for
Very useful:
is highly recommended for
Often counterindicated: is often not recommended for
Often counterindicated:
is often not recommended for