Molybdenum Need

Molybdenum Need: Overview

Molybdenum is an essential trace mineral.  It is needed for the proper function of certain enzyme-dependent processes, including the metabolism of iron.

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Although molybdenum is an essential mineral, no known deficiencies have been reported in humans at the time of writing.  However, molybdenum cofactor deficiency has been identified in a large number of patients.  A diet low in sulfur amino acids can be therapeutic.  Molybdenum cofactor deficiency results in the loss of 2 molybdenum-dependent enzymes, namely sulfate oxidase and xanthine dehydrogenase.

Conditions that suggest Molybdenum Need:

Environment / Toxicity

Copper Toxicity

The exact mechanism by which molybdenum prevents copper toxicity is poorly understood.  However, it is known that an insoluble complex of copper and molybdenum can be formed in the gastrointestinal tract thus reducing copper absorption.  This theory is substantiated by the fact that increasing dietary copper is an effective treatment of molybdenum toxicity.

Lab Values

Uric Acid Levels Low

Xanthine oxidase, the enzyme that immediately produces uric acid, uses molybdenum as a cofactor.  Molybdenum is known to raise uric acid levels, which is why people with gout (a condition of elevated high uric acid levels) are told to avoid molybdenum supplements.

Metabolic

Molybdenum Need suggests the following may be present:

Nutrients

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Molybdenum Need can lead to:

Environment / Toxicity

Copper Toxicity

The exact mechanism by which molybdenum prevents copper toxicity is poorly understood.  However, it is known that an insoluble complex of copper and molybdenum can be formed in the gastrointestinal tract thus reducing copper absorption.  This theory is substantiated by the fact that increasing dietary copper is an effective treatment of molybdenum toxicity.

Recommendations for Molybdenum Need:

Lab Tests/Rule-Outs

Test Copper Levels

Copper and molybdenum are antagonistic.  If copper levels are elevated, copper should be avoided during molybdenum treatment, but rechecked later to make sure it hasn't gone too low.

Mineral

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Weak or unproven link:
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Definite or direct link: strongly suggests
Definite or direct link:
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