Sex Hormone Binding Globulin (SHBG) is a protein produced by the liver which binds to three sex hormones found in both men and women: estrogen, dihydrotestosterone (DHT), and testosterone. SHBG carries these three hormones through the blood to where they are needed.
Decreased SHBG levels are often seen in cases of hirsutism, acne vulgaris and the polycystic ovary syndrome. SHBG levels may be modestly reduced in hypothyroidism, acromegaly, Cushing's disease and hyperprolactinemia.
Although SHBG binds with three hormones, the critical one for testing purposes is testosterone.
The use of dexamethasone in the treatment of women with hyperandrogenic hirsutism typically leads to an increase in SHBG concentrations.
Your body is a highly complex, interconnected system. Instead of guessing at what might be wrong, let us help you discover what is really going on inside your body based on the many clues it is giving.
Our multiple symptom checker provides in-depth health analysis by The Analyst™ with full explanations, recommendations and (optionally) doctors available for case review and answering your specific questions.