Low Sex Hormone
Binding Globulin

Low Sex Hormone Binding Globulin: Overview

Decreased SHBG levels are often seen in cases of hirsutism, acne vulgaris and the polycystic ovary syndrome.  SHBG levels may be modestly reduced in hypothyroidism, acromegaly, Cushing's disease and hyperprolactinemia.

Treatment and Prevention

The use of dexamethasone in the treatment of women with hyperandrogenic hirsutism typically leads to an increase in SHBG concentrations.

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Low Sex Hormone Binding Globulin:

Risk factors for Low Sex Hormone Binding Globulin:

Hormones

Hypothyroidism

Thyroid diseases such as hypothyroid affect hormonal balance.

Lab Values - Hormones

Counter-indicators

Metabolic

Problems Caused By Being Overweight

Obesity tends to increase the levels of sex hormone (estrogen, testosterone) activity, and decrease levels of sex hormone binding globulin.

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Recommendations for Low Sex Hormone Binding Globulin:

Diet

Plant-Based Nutrition

It has been observed that a vegetarian diet is associated with high plasma levels of sex hormone-binding globulin, reducing clearance of sex hormones and probably risk of breast and prostate cancer.

Weight Loss

Obesity tends to decrease levels of sex hormone binding globulin.

Extract

Not recommended
DIM / I3C

Aromatase inhibitors such as DIM, I3C, and Chrysin should be avoided, as they will enhance any preexisting androgen/estrogen dominance.

Lab Tests/Rule-Outs

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