Low Sex Hormone
Binding Globulin

Low Sex Hormone Binding Globulin: Overview

Decreased SHBG levels are often seen in cases of hirsutism, acne vulgaris and the polycystic ovary syndrome.  SHBG levels may be modestly reduced in hypothyroidism, acromegaly, Cushing's disease and hyperprolactenimia.

Treatment and Prevention

The use of dexamethasone in in the treatment of women with hyperandrogenic hirsutism typically leads to an increase in SHBG concentrations.

Low Sex Hormone Binding Globulin

Information On This Page

Risk factors for Low Sex Hormone Binding Globulin:

Hormones

Hypothyroidism often increases risk of Low Sex Hormone Binding GlobulinHypothyroidism
Thyroid diseases such as hypothyroid affect hormonal balance.

Lab Values - Hormones

Counter-indicators:

Metabolic

Problems Caused By Being Overweight often increases risk of Low Sex Hormone Binding GlobulinProblems Caused By Being Overweight
Obesity tends to increase the levels of sex hormone (estrogen, testosterone) activity, and decrease levels of sex hormone binding globulin.

Reproductive

Recommendations for Low Sex Hormone Binding Globulin:

Diet

Plant-Based Nutrition often helps with Low Sex Hormone Binding GlobulinPlant-Based Nutrition
It has been observed that a vegetarian diet is associated with high plasma levels of sex hormone-binding globulin, reducing clearance of sex hormones and probably risk of breast and prostate cancer.
Weight Loss may help with Low Sex Hormone Binding GlobulinWeight Loss
Obesity tends to decrease levels of sex hormone binding globulin.

Extract

Not recommended:
DIM / I3C is often not recommended for Low Sex Hormone Binding GlobulinDIM / I3C
Aromatase inhibitors such as DIM, I3C, and Chrysin should be avoided, as they will enhance any preexisting androgen/estrogen dominance.

Lab Tests/Rule-Outs

KEY

Strong or generally accepted link: often increases risk of
Strong or generally accepted link:
often increases risk of
Definite or direct link: increases risk of
Definite or direct link:
increases risk of
Definitely or absolutely counter-indicates: decreases risk of
Definitely or absolutely counter-indicates:
decreases risk of
May be useful: may help with
May be useful:
may help with
Moderately useful: often helps with
Moderately useful:
often helps with
Very useful: is highly recommended for
Very useful:
is highly recommended for
Often counterindicated: is often not recommended for
Often counterindicated:
is often not recommended for