The 'low', 'normal' and 'high' ranges vary with age, and are also lab-specific. However, a reasonable normal range is 0.002-0.2mg/dl.
A high level of IgE can indicate a parasite infection. Also, high levels of IgE are found in people who have allergic reactions, asthma, atopic dermatitis, some types of cancer, and certain autoimmune diseases. Rarely, a high level of IgE may indicate IgE multiple myeloma.
IgE myeloma is extremely rare and should be sought after abnormal protein electrophoresis (restriction) and/or abnormal kappa/lambda ratio unexplained by IgG, IgA, or IgM. The principal limitation of this test is the wide overlapping range of IgE values between atopic and non-atopic disease states. IgE is elevated 4-30 times normal in various diseases, among which atopic disorders and parasitic disorders are most prominent.