Serum copper levels in these patients are abnormally high. Since copper is a brain stimulant and destroys histamine, the elevated serum (and presumably brain) copper level probably accounts for many symptoms, including the low blood histamine level. Histapenia (hista-: histamine; -penia: deficiency of) is a shortage of histamine in the body. Histamine is an important brain chemical involved in many reactions.
It has been found that 50% of patients classified as "schizophrenic" have low histamine levels in the blood and it rises to normal as they improve. These same patients are found to have high copper levels. Elevated copper decreases blood histamine. Excess copper is linked with psychosis. People with histapenia tend to have classic signs of schizophrenia, including canker sores, difficult orgasm with sex, no headaches or allergies, heavy growth of body hair, ideas of grandeur, undue suspicion of people, racing thoughts, the feeling that someone controls one's mind, seeing or hearing things abnormally, ringing in the ears, and others.
Zinc should be given once testing confirms a low zinc or high copper level. Zinc and manganese allow for the normal storage of histamine in both basophils and the brain. During treatment, the largest tissues of the body – namely the liver and muscles – are flushed of their copper first so that the serum copper may rise to aggravate mental symptoms. If this occurs then the dose of zinc should be reduced for a two week period.
Excess copper may be acquired from commercial vitamins and minerals or drinking water flowing through copper pipes. Distilled water may occasionally be needed to reduce copper intake.