Histapenia (Histamine Low)

Histapenia (Histamine Low): Overview

Serum copper levels in these patients are abnormally high.  Since copper is a brain stimulant and destroys histamine, the elevated serum (and presumably brain) copper level probably accounts for many symptoms, including the low blood histamine level. Histapenia (hista-: histamine; -penia: deficiency of) is a shortage of histamine in the body.  Histamine is an important brain chemical involved in many reactions.

Signs and Symptoms

Behavioral symptoms in high-copper histapenia include paranoia and hallucinations in younger patients, but depression may predominate in older patients.  The patient is usually classified as having chronic or process schizophrenia.  Some studies of schizophrenics have revealed high blood copper, as seen in histadelia, with low urinary copper (showing that copper is being retained) as well as low blood zinc.

Treatment and Prevention

The treatment program consists of the administration of zinc, manganese, vitamin C, niacin, vitamin B12, and folic acid.  With this treatment the high blood copper is slowly reduced and symptoms are slowly relieved in several months' time.

Low Histamine

Information On This Page
Signs and symptoms Conditions that suggest it Contributing risk factors What has similar symptoms Recommendations

Signs, symptoms & indicators of Histapenia (Histamine Low):

Symptoms - Mind - General

Occasional/frequent racing thoughts is often a sign or symptom of Histapenia (Histamine Low)Occasional/frequent racing thoughts

Symptoms - Nervous

(Very) high tolerance for pain is often a sign or symptom of Histapenia (Histamine Low)(Very) high tolerance for pain
Counter-indicators:
(Very) low tolerance for pain often contraindicates Histapenia (Histamine Low)(Very) low tolerance for pain

Conditions that suggest Histapenia (Histamine Low):

Hormones

Low Sex Drive often suggests Histapenia (Histamine Low)Low Sex Drive

Mental

Depression often suggests Histapenia (Histamine Low)Depression

Risk factors for Histapenia (Histamine Low):

Childhood

(Severe) childhood hyperactivity often increases risk of Histapenia (Histamine Low)(Severe) childhood hyperactivity
Low histamine children are hyperactive while often healthy in other respects.

Histapenia (Histamine Low) could instead be:

Mental

Schizophrenia is sometimes misdiagnosed as Histapenia (Histamine Low)Schizophrenia
It has been found that 50% of patients classified as "schizophrenic" have low histamine levels in the blood and it rises to normal as they improve.  These same patients are found to have high copper levels.  Elevated copper decreases blood histamine.  Excess copper is linked with psychosis.  People with histapenia tend to have classic signs of schizophrenia, including canker sores, difficult orgasm with sex, no headaches or allergies, heavy growth of body hair, ideas of grandeur, undue suspicion of people, racing thoughts, the feeling that someone controls one's mind, seeing or hearing things abnormally, ringing in the ears, and others.

Recommendations for Histapenia (Histamine Low):

Amino Acid / Protein

Histidine often helps with Histapenia (Histamine Low)Histidine

Diet

High/Increased Protein Diet often helps with Histapenia (Histamine Low)High/Increased Protein Diet

Lab Tests/Rule-Outs

Test Copper Levels is highly recommended for Histapenia (Histamine Low)Test Copper Levels
Test Histamine Levels is highly recommended for Histapenia (Histamine Low)Test Histamine Levels
Test for Manganese Levels is highly recommended for Histapenia (Histamine Low)Test for Manganese Levels
Test Zinc Levels often helps with Histapenia (Histamine Low)Test Zinc Levels

Mineral

Manganese is highly recommended for Histapenia (Histamine Low)Manganese
Copper levels are usually elevated in patients with histapenia.  Manganese and zinc supplementation increase copper excretion.
Not recommended:
Copper is NOT recommended for Histapenia (Histamine Low)Copper
Excess copper may be acquired from commercial vitamins and minerals or drinking water flowing through copper pipes.  Distilled water may occasionally be needed to reduce copper intake.

Nutrient

Essential Fatty Acids often helps with Histapenia (Histamine Low)Essential Fatty Acids

Vitamins

Folic Acid is highly recommended for Histapenia (Histamine Low)Folic Acid
The rationale underlying this treatment is that folic acid in conjunction with vitamin B12 injections raises the blood histamine while lowering the degree of symptoms.
Vitamin B3 (Niacin) is highly recommended for Histapenia (Histamine Low)Vitamin B3 (Niacin)
Vitamin C (Ascorbic Acid) often helps with Histapenia (Histamine Low)Vitamin C (Ascorbic Acid)
Zinc and manganese with vitamin C remove copper from the tissues.  Copper destroys histamine and therefore as copper levels decrease, histamine levels should return towards normal.
Vitamin B12 (Cobalamine) often helps with Histapenia (Histamine Low)Vitamin B12 (Cobalamine)
Vitamin B6 (Pyridoxine) often helps with Histapenia (Histamine Low)Vitamin B6 (Pyridoxine)

KEY

Strong or generally accepted link: is often a sign or symptom of; often suggests; often increases risk of; is sometimes misdiagnosed as
Strong or generally accepted link:
is often a sign or symptom of; often suggests; often increases risk of; is sometimes misdiagnosed as
Strong counter-indication: often contraindicates
Strong counter-indication:
often contraindicates
Moderately useful: often helps with
Moderately useful:
often helps with
Very useful: is highly recommended for
Very useful:
is highly recommended for
Should be avoided: is NOT recommended for
Should be avoided:
is NOT recommended for
Last updated: Apr 25, 2013