Many high-protein diets could potentially be harmful to people who are genetically predisposed to a given health condition. Genetics is a major factor in the development of many health problems, but the environment to which genes are exposed also plays a significant role. In general, high protein diets, depending on the food choices of the diet, increase risk for the following: inadequate vitamins and minerals (especially antioxidants), low fiber intake, high total and saturated fat intake, excess caloric intake, excess protein intake. These problems can have long-term negative impacts.
High-protein diets may trigger food allergies. Food allergies often arise when protein is poorly digested and/or particular protein-containing foods are consumed too frequently.
High protein intakes may lead to dehydration due to excessive urine output (related to ketone production).