Atrophic Gastritis

Atrophic Gastritis: Overview

This is a common condition in the elderly which comes from the inability to secrete sufficient stomach acid to kill bacteria.  Ingested bacteria can thus survive and reside in the stomach and the upper part of the small bowel.  This problem affects approximately 20% of people between 60 and 69 years of age, and 40% of people over 80. These bacteria, which are not killed by the normal stomach acid, interfere with the absorption of vitamin B12.  Putting these patients on antibiotics to reduce the number of bacteria returns their B12 levels to normal.  The deficiency of vitamin B12 may not be severe enough to show up in the blood, but it can be associated with psychiatric dementias.  These deficiencies may be disguised as Alzheimer's disease or senile dementia.

Atrophic gastritis is characterized by atrophy of the stomach wall with reduced or absent gastric acid secretion.  It may also lead to reduced levels of intrinsic factor.

Treatment and Prevention

A significant number of elderly people have atrophic gastritis with hypo- or achlorhydria, predisposing them to bacterial overgrowth.  A study showed that elderly atrophic gastritis subjects are more easily populated with specific lactobacilli than normal subjects.  This study also showed that organisms found in yogurt have no impact on the flora of healthy elderly subjects and a relatively small impact on elderly atrophic gastritis subjects.

Lactobacillus gasseri was the only one among several organisms administered that was successfully implanted in healthy and atrophic gastritis individuals.

Atrophic Gastritis

Information On This Page

Signs, symptoms & indicators of Atrophic Gastritis:

Symptoms - Food - General

Symptoms - Gas-Int - General

Symptoms - Metabolic

Conditions that suggest Atrophic Gastritis:

Circulation

Megaloblastic Anemia / Pernicious Anemia often suggests Atrophic GastritisMegaloblastic Anemia / Pernicious Anemia
Gastric autoimmune disease has been classified into types A and B, based on the changes in different portions of the stomach.  Patients with antibodies to parietal cells (PCA) or intrinsic factor, or both, have atrophy of the fundal mucosa (Type A) and a very high rate of pernicious anemia, often associated with other autoimmune endocrine disorders.  In cases of Type B gastritis, PCA are lacking and there is no association with pernicious anemia or other autoimmune endocrine disorders.

Digestion

Metabolic

Edema (Water Retention) may suggest Atrophic GastritisEdema (Water Retention)
Edema may be due to low levels of circulating proteins from poor protein digestion.

Musculo-Skeletal

Rheumatoid Arthritis often suggests Atrophic GastritisRheumatoid Arthritis
Chronic atrophic gastritis occurs in up to 63% of rheumatoid arthritis patients.  Achlorhydria also occurs frequently and is associated with changes in gastric microbial patterns.
Osteoporosis - Osteopenia often suggests Atrophic GastritisOsteoporosis - Osteopenia
Stomach acid is required to enhance the absorption of minerals such as calcium.  Reduced calcium absorption encourages bone loss.

Nutrients

Zinc Requirement may suggest Atrophic GastritisZinc Requirement
Those with atrophic gastritis, vagotomy or gastric resection may be at increased risk for zinc deficiency.

Symptoms - Gas-Int - General

Counter-indicators:

Atrophic Gastritis can lead to:

Digestion

Musculo-Skeletal

Atrophic Gastritis sometimes leads to Rheumatoid ArthritisRheumatoid Arthritis
Chronic atrophic gastritis occurs in up to 63% of rheumatoid arthritis patients.  Achlorhydria also occurs frequently and is associated with changes in gastric microbial patterns.

Tumors, Malignant

Atrophic Gastritis sometimes leads to Stomach CancerStomach Cancer
Gastric cancer is 5 to 10 times more likely in those with chronic atrophic gastritis; the same increased incidence is also found in first-degree relatives of patients with gastric cancer and pernicious anemia.

Recommendations for Atrophic Gastritis:

Digestion

Lab Tests/Rule-Outs

Mineral

Iron may help with Atrophic GastritisIron
Ferric iron absorption is decreased in achlorhydria but heme iron absorption is not.

Vitamins

Vitamin C (Ascorbic Acid) often helps with Atrophic GastritisVitamin C (Ascorbic Acid)
There may be a localized deficiency of Vitamin C in atrophic gastritis.  Recent evidence suggests that beta-carotene and/or vitamin C along with vitamin E may reverse or reduce the risk of atrophic gastritis and/or gastric cancer.  Another study showed vitamin C levels to be low in atrophic gastritis and Helicobacter Pylori infection.

KEY

Weak or unproven link: may be a sign or symptom of; may suggest; sometimes leads to
Weak or unproven link:
may be a sign or symptom of; may suggest; sometimes leads to
Strong or generally accepted link: is often a sign or symptom of; often suggests; often leads to
Strong or generally accepted link:
is often a sign or symptom of; often suggests; often leads to
Definite or direct link: strongly suggests
Definite or direct link:
strongly suggests
Definitely or absolutely counter-indicates: strongly contraindicates
Definitely or absolutely counter-indicates:
strongly contraindicates
May be useful: may help with
May be useful:
may help with
Moderately useful: often helps with
Moderately useful:
often helps with
Very useful: is highly recommended for
Very useful:
is highly recommended for