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Question Category:
SUPPLEMENTS AND MEDICATIONS
 


In the 'Supplements And Medications' section of our in-depth questionnaire we ask the following question about H2-blocker antacid use:
 
Have you used H2 blockers such as Tagamet, Pepcid or Zantac?

 

Your answer  

...indicates  

...and suggests
1.   "No / don't know"      
2.   "Minor use in the past"    Past H2-blocker antacid use   A risk factor
3.   "Significant use in the past"    Past H2-blocker antacid use   A risk factor
4.   "Currently using, for up to 6 months"    H2-blocker antacid use   A risk factor
5.   "Currently using, for over 6 months"    H2-blocker antacid use   A risk factor


Your answer will affect the likelihoods of the conditions below.  Any answers in green reduce the likelihood of the condition.
 
Answers Condition Comment

 

 

 

4

5

Heartburn / GERD / Acid Reflux

--

 

 

3

4

5

Increased Folic Acid Requirement

There is some evidence that H2 blockers may slightly reduce the absorption of folate. Folate is an important nutrient and one that is commonly deficient in the diet, so if you are taking H2 blockers you should probably take folate supplements as well.

 

 

3

4

5

Iron Requirement

By reducing stomach acid levels, H2 blockers might interfere with the absorption of iron, zinc, and perhaps other minerals.

 

 

3

4

5

Vitamin B12 Requirement

H2-receptor blockers appear to impair the absorption of vitamin B12 from food. This is thought to occur because the vitamin B12 in food is attached to proteins. Stomach acid separates them and allows the B12 to be absorbed.

 

 

3

4

5

Zinc Requirement

By reducing stomach acid levels, H2 blockers might interfere with the absorption of iron, zinc and perhaps other minerals. Gastric acid secretion plays an important role in the regulation of zinc absorption in men. Drugs that keep stomach pH values of 3 or greater for at least 24 hours may predispose individuals to zinc deficiency.



GLOSSARY

Cobalamin (B12, B-12, Cobalamine, Vitamin B12)
Essential for normal growth and functioning of all body cells, especially those of bone marrow (red blood cell formation), gastrointestinal tract and nervous system, it prevents pernicious anemia and plays a crucial part in the reproduction of every cell of the body i.e. synthesis of genetic material (DNA).

Gastric
Of, relating to, or associated with the stomach.

H2 Blockers (H2 Blocker)
Medications in this family sharply decrease stomach acid production. They are widely used for the treatment of ulcers as well as for mild cases of esophageal reflux (heartburn). Drugs that fall into this family include cimetidine (Tagamet, Tagamet HB); famotidine (Pepcid, Pepcid AC, Pepcid RPD); nizatidine (Axid, Axid AR); ranitidine hydrochloride (Zantac, Zantac EFFERdose, Zantac GELdose, Zantac 75).

Iron
An essential mineral. Prevents anemia: as a constituent of hemoglobin, transports oxygen throughout the body. Virtually all of the oxygen used by cells in the life process are brought to the cells by the hemoglobin of red blood cells. Iron is a small but most vital, component of the hemoglobin in 20,000 billion red blood cells, of which 115 million are formed every minute. Heme iron (from meat) is absorbed 10 times more readily than the ferrous or ferric form.

Mineral (Minerals)
Plays a vital role in regulating many body functions. They act as catalysts in nerve response, muscle contraction and the metabolism of nutrients in foods. They regulate electrolyte balance and hormonal production, and they strengthen skeletal structures.

pH
A measure of an environment's acidity or alkalinity. The more acidic the solution, the lower the pH. For example, a pH of 1 is very acidic; a pH of 7 is neutral; a pH of 14 is very alkaline.

Protein (Proteins)
Compounds composed of hydrogen, oxygen, and nitrogen present in the body and in foods that form complex combinations of amino acids. Protein is essential for life and is used for growth and repair. Foods that supply the body with protein include animal products, grains, legumes, and vegetables. Proteins from animal sources contain the essential amino acids. Proteins are changed to amino acids in the body.

Stomach
A hollow, muscular, J-shaped pouch located in the upper part of the abdomen to the left of the midline. The upper end (fundus) is large and dome-shaped; the area just below the fundus is called the body of the stomach. The fundus and the body are often referred to as the cardiac portion of the stomach. The lower (pyloric) portion curves downward and to the right and includes the antrum and the pylorus. The function of the stomach is to begin digestion by physically breaking down food received from the esophagus. The tissues of the stomach wall are composed of three types of muscle fibers: circular, longitudinal and oblique. These fibers create structural elasticity and contractibility, both of which are needed for digestion. The stomach mucosa contains cells which secrete hydrochloric acid and this in turn activates the other gastric enzymes pepsin and rennin. To protect itself from being destroyed by its own enzymes, the stomach’s mucous lining must constantly regenerate itself.

Zinc
An essential trace mineral. The functions of zinc are enzymatic. There are over 70 metalloenzymes known to require zinc for their functions. The main biochemicals in which zinc has been found to be necessary include: enzymes and enzymatic function, protein synthesis and carbohydrate metabolism. Zinc is a constituent of insulin and male reproductive fluid. Zinc is necessary for the proper metabolism of alcohol, to get rid of the lactic acid that builds up in working muscles and to transfer it to the lungs. Zinc is involved in the health of the immune system, assists vitamin A utilization and is involved in the formation of bone and teeth.




Last updated: May 10, 2007


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