An essential mineral found in trace amounts in tissues of the body. Adults normally contain an average of 10 to 20mg of manganese in their bodies, most of which is contained in bone, the liver and the kidneys. Manganese is essential to several critical enzymes necessary for energy production, bone and blood formation, nerve function and protein metabolism. It is involved in the metabolism of fats and glucose, the production of cholesterol and it allows the body to use thiamine and Vitamin E. It is also involved in the building and degrading of proteins and nucleic acid, biogenic amine metabolism, which involves the transmitting of nerve impulses.

	Alfalfa As A Treatment "...The powdered form also contains high amounts of calcium, phosphorus, manganese, iron, zinc, and copper..." Allergic Rhinitis / Hay Fever Recommendation Test for Manganese Levels "Low blood manganese levels may accentuate allergies..." Atherosclerosis Relationship to Manganese Requirement "Manganese strengthens arterial tissues, making them more resistant to plaque formation..." Attention Deficit Hyperactivity Disorder (ADHD) Recommendation Test Zinc Levels "Hyperactive children may be deficient in zinc, manganese and vitamin B6 and have an excess of lead and copper..." Cirrhosis of the Liver Relationship to Manganese Requirement "Preliminary research suggests that individuals with cirrhosis may not be able to properly excrete manganese..." Copper Toxicity Recommendation Vitamin C (Ascorbic Acid) "See link between copper toxicity and manganese..." Recommendation Zinc "Zinc and manganese with vitamin C remove copper from the tissues..." Recommendation Manganese "Vitamin C, zinc and manganese all interfere with copper absorption..." Depression Relationship to Manganese Requirement "Low blood manganese levels may accentuate depression..." Diabetes Type II Relationship to Manganese Requirement "People with diabetes often have low manganese levels and this deficiency contributes to an inability to process sugars..." Female Hair Loss Relationship to Zinc Requirement "See the link between Hair Loss and Manganese..." Relationship to Manganese Requirement "Mineral metabolism of 19 patients with hair loss was examined and the analysis showed manganese deficiency in all..." General Mineral Requirement The Condition "...More than 70% of other essential trace minerals such as manganese, boron, chromium and selenium also are lost..." Heavy Metal Toxicity The Condition "...Some heavy metals - such as cobalt, copper, iron, manganese, molybdenum, vanadium, strontium, and zinc - are essential to health in trace amounts..." Relationship to Parkinson's Disease "Metals such as iron, manganese, cadmium, copper, and mercury (from dental amalgams) have been implicated as causative factors in the development of Parkinson's disease..." Hemochromatosis (Iron overload) Recommendation Manganese "Manganese can protect against the free radical damage from excess iron..." High Levels Of Triglycerides Relationship to Manganese Requirement "See the link between Low HDL/LDL Cholesterol Ratio and Manganese Need..." High Total Cholesterol Relationship to Manganese Requirement "See the link between Low HDL/LDL Cholesterol Ratio and Manganese Need..." Histapenia (Histamine Low) The Condition "...Treatment & Prevention The treatment program consists of the administration of zinc, manganese, vitamin C, niacin, vitamin B12, and folic acid..." Recommendation Zinc "...Zinc and manganese allow for the normal storage of histamine in both basophils and the brain..." Recommendation Manganese "...Manganese and zinc supplementation increase copper excretion..." Recommendation Vitamin C (Ascorbic Acid) "Zinc and manganese with vitamin C remove copper from the tissues..." Hyperparathyroidism The Condition "...with primary hyperparathyroidism who also has borderline nutritional status may develop deficiencies in the following substances that are necessary for normal bone formation: Vitamin C, Vitamin K, Manganese..." Indoor Allergies Recommendation Test for Manganese Levels "Low blood manganese levels may accentuate allergies..." LDL/HDL Ratio, High Relationship to Manganese Requirement "Manganese can help lower high triglyceride and cholesterol levels, with a particular effect on stabilizing LDL and decreasing its atherogenic potential..." Male Hair Loss Relationship to Calcium Requirement "See the link between Hair Loss and Manganese..." Relationship to Manganese Requirement "...The analysis showed manganese deficiency in all 19..." Relationship to Zinc Requirement "See the link between Hair Loss and Manganese..." Manganese As A Treatment "Sometimes called a "cell protector", the name manganese comes from the Greek word for magic, because it was thought to have magical properties..." Manganese Requirement The Condition "Causes & Development The increasing consumption of refined flours and sugars is the now the most common cause of low manganese levels..." Our Question about Perthes disease "Zinc, Manganese and vitamin B6 have been helpful in treating osteochondrosis (Leg-hip Perthes disease)..." Metabolic Diet Type The Condition "...Nutrients to De-emphasize: Potassium, Magnesium, Chromium, Copper, Iron, Manganese, Silicone, Boron, Vitamins B1, B2, B3, B6, C, D, Paba, biotin, and Folic acid..." Multiple Mineral Supplementation As A Treatment "...Trace minerals include boron, chromium, copper, germanium, iodine, iron, manganese, molybdenum selenium, silicon, sulfur, vanadium and zinc..." Multiple Vitamin Need The Condition "...a marginal nutrient status? Treatment & Prevention Select populations will benefit from specific supplementation as in the following examples ... A 1989 study found calcium, magnesium, iron and manganese were low in teenage girls..." Multiple Vitamin Supplement As A Treatment "..... The best multiple vitamins should contain a broad range of vitamins and minerals, particularly vitamins A, D, K, all of the B vitamins, and trace minerals, like boron, chromium, copper, iron, manganese, selenium, and zinc..." Myasthenia Gravis Recommendation Manganese "Manganese deficiency has been linked to myasthenia gravis..." Osteoarthritis Relationship to Manganese Requirement "Bone cartilage can’t grow or repair itself adequately without manganese - an essential part of glucosamine, which is in turn a major joint building block..." Osteoporosis - Osteopenia Relationship to Manganese Requirement "Individuals with osteoporosis sometimes have low blood levels of manganese..." Recommendation Copper "Trace minerals (zinc, copper, manganese, and boron) are required for strong bone formation..." Recommendation Calcium "...One study found that a supplement containing calcium, manganese, zinc and copper prevented bone loss in postmenopausal women, whereas calcium alone was ineffective..." Parkinson's Disease The Condition "...of this research is that one can lower one's risk of developing Parkinson's disease by reducing one's intake of animal fats and sugar, avoiding excessive exposure to metals such as aluminum, iron, manganese, mercury, cadmium and copper, and by ensuring an adequate intake of antioxidants..." Poor/Slow Wound Healing Recommendation Vitamin B5 (Pantothenic Acid) "...These "recruited" minerals included copper, magnesium, and manganese, all proven to enhance wound repair..." Pregnancy-Related Issues Relationship to Manganese Requirement "There is a risk of fetal malformations, including increases in neural tube defects, without an adequate amount of manganese..." Premenstrual Syndrome Relationship to Manganese Requirement "In a double blind study of women with normal menstrual cycles, lower dietary manganese (1..." Pyroluria The Condition "...Supplementation with vitamin B6 until daily dream recall returns (a normal phenomenon) as well as with zinc and manganese needs to be continued daily..." Recommendation Vitamin B6 (Pyridoxine) "Pyrolurics commonly respond within a few months to B6, zinc and manganese..." Rheumatoid Arthritis Recommendation Manganese "Manganese functions in the antioxidant enzyme superoxide dismutase (manganese SOD), which is deficient in patients with rheumatoid arthritis..." Recommendation Superoxide Dismutase "In a Danish study, arthritis patients were treated with injections of superoxide dismutase, an enzyme containing copper (or manganese and zinc) that is found within the cells..." Seizure Disorder Relationship to Manganese Requirement "At least six different studies have confirmed confirmed that people who experience seizures have below normal manganese levels..." Recommendation Test for Manganese Levels "Sohler (1979) compared blood manganese (Mn) levels in a group of patients with seizure activity to those in a control group..." Superoxide Dismutase As A Treatment "...Nevertheless, three minerals are needed by the body to make its own SOD: zinc, copper and manganese..." Tardive Dyskinesia Relationship to Manganese Requirement "Administration of the trace mineral manganese (at 15mg per day) may prevent the development of tardive dyskinesia and higher amounts (up to 60mg per day) may reverse tardive dyskinesia that has already developed..." Recommendation Melatonin "...Other natural substances that have been reported to improve tardive dyskinesia include vitamin E, manganese and vitamin B6..." Test for Manganese Levels As A Treatment "Whole blood manganese levels are considered to be a reliable measure of body manganese..." Vitamin B6 Requirement Our Question about Perthes disease "Zinc, Manganese and vitamin B6 have been helpful in treating osteochondrosis (Leg-hip Perthes disease)..." Weakened Immune System The Condition "...A high-quality multivitamin and mineral supplement (especially B6, B12, folate, pantothenic acid, C, zinc, selenium, chromium, and manganese) can be an important starting point..." Zinc Requirement The Condition "...Along with copper and manganese, zinc is a precursor of the antioxidant enzyme superoxide dismutase (SOD)..." Our Question about Perthes disease "Zinc, Manganese and vitamin B6 have been helpful in treating osteochondrosis (Leg-hip Perthes disease)..." Zinc Toxicity Relationship to Manganese Requirement "An insidious effect of excess zinc over a period of years is the reduction of serum manganese, 90% of which is contained in the erythrocytes..." Relationship to Autoimmune Tendency "Prolonged large doses of zinc may, by lowering manganese levels, increase susceptibility to autoimmune reactions..." Recommendation Test for Manganese Levels "Zinc causes a decrease in serum manganese levels..."

Last updated: May 10, 2007