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Low Sex Hormone
Binding Globulin
  Sex Hormone Binding Globulin, Low
 Contributing risk factors
 Treatment recommendations
 


Decreased SHBG levels are often seen in cases of hirsutism, acne vulgaris and the polycystic ovary syndrome. SHBG levels may be modestly reduced in hypothyroidism, acromegaly, Cushing's disease and hyperprolactenimia.

Treatment & Prevention


The use of dexamethasone in in the treatment of women with hyperandrogenic hirsutism typically leads to an increase in SHBG concentrations.





Risk factors for Low Sex Hormone Binding Globulin:
Hormones  Hypothyroidism
 Thyroid diseases such as hypothyroid affect hormonal balance.

Lab Values - Hormones

  Very/moderately low SHBG

Counter-indicators:
  Elevated SHBG

Metabolic

  Problems Caused By Being Overweight
 Obesity tends to increase the levels of sex hormone (estrogen, testosterone) activity, and decrease levels of sex hormone binding globulin.

Uro-Genital

  Polycystic Ovary Syndrome (PCOS)

Recommendations and treatments for Low Sex Hormone Binding Globulin:
Diet  Plant-Based Nutrition
 It has been observed that a vegetarian diet is associated with high plasma levels of sex hormone-binding globulin, reducing clearance of sex hormones and probably risk of breast and prostate cancer.

  Weight Loss
 Obesity tends to decrease levels of sex hormone binding globulin.

Extract

Not recommended:
  DIM (di-indolmethane)/I3C (Indole-3-Carbinol)
 Aromatase inhibitors such as DIM, I3C, and Chrysin should be avoided, as they will enhance any preexisting androgen/estrogen dominance.

Lab Tests/Rule-Outs

  Test Sex Hormone Binding Globulin (SHBG)


KEY
Strong or generally accepted link
Proven definite or direct link
Very strongly or absolutely counter-indicative
May do some good
Likely to help
Highly recommended
Reasonably likely to cause problems


GLOSSARY

Acne
A chronic skin disorder due to inflammation of hair follicles and sebaceous glands (secretion glands in the skin).

Androgen
Any steroid hormone that increases male characteristics.

Cancer
Refers to the various types of malignant neoplasms that contain cells growing out of control and invading adjacent tissues, which may metastasize to distant tissues.

Estrogen (Oestrogen)
One of the female sex hormones produced by the ovaries.

Hormones (Hormone)
Chemical substances secreted by a variety of body organs that are carried by the bloodstream and usually influence cells some distance from the source of production. Hormones signal certain enzymes to perform their functions and, in this way, regulate such body functions as blood sugar levels, insulin levels, the menstrual cycle, and growth. These can be prescription, over-the-counter, synthetic or natural agents. Examples include adrenal hormones such as corticosteroids and aldosterone; glucagon, growth hormone, insulin, testosterone, estrogens, progestins, progesterone, DHEA, melatonin, and thyroid hormones such as thyroxine and calcitonin.

Hypothyroidism (Hypothyroid)
Diminished production of thyroid hormone, leading to low metabolic rate, tendency to gain weight, and sleepiness.

Ovary (Ovaries)
Ovaries are about the size of an almond and lie on either side of the lower abdomen beside the uterus. They usually produce one egg each month and whether the egg is fertilized or not, the reproductive process follows a monthly cycle, with constant changes in various hormone levels, preparing another opportunity for conception. The ovary is responsible for most of the estrogen production in women. At menopause (sometime after middle-age), egg production ceases and hormone levels drop significantly.

Prostate
The prostate gland in men that surrounds the neck of the bladder and the urethra and produces a secretion that liquefies coagulated semen.

SHBG (Sex Hormone Binding Globulin, Sex Hormone-Binding Globulin)
A glycoprotein, synthesized in the liver, which binds testosterone and 5 alpha-dihydrotestosterone strongly, and estradiol somewhat less strongly. Circulating testosterone is mainly bound to protein - primarily SHBG, but also to albumin and cortisol-binding globulin. Since variations in the carrier protein levels may affect the concentration of testosterone in circulation, SHBG levels are commonly measured as a supplement to total testosterone determinations. The "free androgen index" (FAI), calculated as the ratio of total testosterone to SHBG, has proved to be a useful indicator of abnormal androgen status in conditions such as hirsutism.

Syndrome
A medical condition characterized by a collection of related symptoms (what the patient feels) and signs (what a doctor can observe or measure).

Testosterone
The principal male sex hormone that induces and maintains the changes that take place in males at puberty. In men, the testicles continue to produce testosterone throughout life, though there is some decline with age. A naturally occurring androgenic hormone.

Thyroid (Thyroid Gland)
The thyroid gland is an organ with many veins, anchored around the front of the throat near the voice box. It is essential to normal body growth in infancy and childhood. It absorbs iodine from the diet and releases thyroid hormones - iodine-containing compounds that help govern the rate of the body's metabolism (its total life processes), affecting body temperature, and regulating protein, fat and carbohydrate catabolism in all cells. They keep up growth hormone release, skeletal maturation, and heart rate, force, and output. They promote central nervous system growth, stimulate the making of many enzymes, and are necessary for muscle tone and vigor. To a high degree, metabolism is regulated by the hormone thyroxine, which can be made by the thyroid if enough organic iodine is available. An enlarged thyroid gland that is not cancer is sometimes called goitre.

Vegetarian (Lacto-Ovo-Vegetarian, Vegetarianism, Vegetarians)
A person who consumes no meat, fish or fowl (chicken, turkey, etc.), but who may consume animal products such as dairy products (milk, cheese, butter, etc.), eggs or honey.




Last updated: Nov 21, 2008


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