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Progesterone Excess
  Progesterone Excess
 Signs, symptoms, indicators
 Conditions that suggest it
 Contributing risk factors
 It can lead to...
 Treatment recommendations
 


Signs & Symptoms


Approximately 30-40% of menopausal women who take progesterone experience unpleasant PMS-like symptoms such as moodiness, irritably, breast tenderness and muscle aches. Individuals who have had significant premenstrual symptoms while they were premenopausal are more likely to be affected.

Treatment & Prevention
Some women respond to even very low doses of progesterone with symptoms of excess. This is not so much an excess susceptibility as an indication that these women's endogenous production is adequate to provide for their needs. In practice, the range of progesterone tolerance can be quite narrow, and a tiny dose is all that is needed to complete the balance between the estrogens and progesterone.

Progestins produce moodiness and irritability by effecting specific sites in the brain. Changing the type of progesterone, the dose, the route of administration and the length of treatment can lessen this effect.





Signs, symptoms & indicators of Progesterone Excess:
Lab Values - Hormones  High progesterone level

Symptoms - Mind - Emotional

  Depression with fatigue

Symptoms - Reproductive - Female Cycle

  Breast soreness during cycle

Symptoms - Sleep

  Drowsiness

Conditions that suggest Progesterone Excess:
Hormones  Low Sex Drive

Infections

  Cystitis, Bacterial bladder Infection
 One mysterious effect in the progesterone intolerant women is bladder problems. Some women have either a great increase in urinary tract infections or a feeling like they are having an infection as soon as they try taking a "normal" progesterone dose. If bladder symptoms start and stop with starting and stopping progesterone, they may be related.

  Yeast / Candida Infection

Symptoms - Immune System

  General fungal/yeast infections

Risk factors for Progesterone Excess:
Supplements and Medications  Taking high dose progesterone
  Taking excesssive/on normal dose oral progesterone
 Progesterone in high doses can cause side-effects. In one study, oral micronized progesterone at a dose of 400mg per day was associated with dizziness, abdominal cramping, headache, breast pain, muscle pain, irritability, nausea, fatigue, diarrhea and viral infections.[Medical Economics; 1999: p.125]

  High sublingual progesterone use
  On moderate/on high dose progesterone

Symptoms - Immune System

  Past general fungal/yeast infections

Symptoms - Reproductive - General

Counter-indicators:
  Being in early pregnancy

Progesterone Excess can lead to:
Hormones  Low Sex Drive

Recommendations and treatments for Progesterone Excess:
HormoneNot recommended:
  Natural Progesterone

Lab Tests/Rule-Outs

  Test for Hormones


KEY
Weak or unproven link
Strong or generally accepted link
Proven definite or direct link
Very strongly or absolutely counter-indicative
Highly recommended
Reasonably likely to cause problems


GLOSSARY

Abdomen (Abdominal)
That part of the body between the chest and the hips that contains the stomach, intestines, liver, bladder, pancreas and other organs.

Cramp (Cramping, Cramps)
A sudden, involuntary, painful muscular contraction.

Diarrhea
Excessive discharge of contents of bowel.

Endogenous
From within the body, either a native function or the product of the extended colony. Normal flora in the colon are considered endogenous.

Menopause (Menopausal)
The cessation of menstruation (usually not official until 12 months have passed without periods), occurring at the average age of 52. As commonly used, the word denotes the time of a woman's life, usually between the ages of 45 and 54, when periods cease and any symptoms of low estrogen levels persist, including hot flashes, insomnia, anxiety, mood swings, loss of libido and vaginal dryness. When these early menopausal symptoms subside, a woman becomes postmenopausal.

Milligram (mg, Milligrams)
0.001 or a thousandth of a gram.

Nausea
Symptoms resulting from an inclination to vomit.

Premenopause (Premenopausal)
The period when women of childbearing age experience relatively normal reproductive function (including regular periods).

Progesterone
This is the hormone secreted after ovulation by the corpus luteum. It is a steroid (similar to a cholesterol), enters receptive cells to stimulate their growth, and acts as an anabolic agent. Estrogen should be viewed as the primary coat underneath all the cycles during a woman's reproductive years, with progesterone, its antagonist, surging for ten or twelve days in ovulatory months. Most of the actions of progesterone cannot occur without estrogen having previously induced the growth of progesterone-receptive binding sites.

Urinary Tract (UT)
The kidneys and the lower urinary tract, which includes the ureters, bladder, and urethra.




Last updated: May 26, 2008


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