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Thyroid Cancer
  Cancer, Thyroid
 Conditions that suggest it
 Contributing risk factors
 Conditions suggested by it
 Treatment recommendations
 Prevention
 


Thyroid cancers are relatively rare and develop from cells of the thyroid gland. If the cancer is not treated, cancer cells from the original site may break away and spread to other parts of the body. Risk Factors


Risk factors include:
  • Gender - Thyroid cancer is slightly more common in women than in men.
     
  • Radiation - People who have had radiotherapy applied to their neck, or who work with certain radioactive substances (e.g. nuclear industry workers, scientists or students) have an increased risk of thyroid cancer later in life (often 10-30 years later). This risk is highest when treatment took place at a young age. There was a high incidence of thyroid cancer in Belorussian and Ukranian children who have been exposed to radiation after the Chernobyl accident.
     
  • Genetic conditions - About 1 in 10 people with a certain type of thyroid cancer called medullary thyroid cancer carry an abnormal gene. This condition is known as MEN2 syndrome. They may pass the gene on to the next generation. A family member with this genetic defect is at an increased risk of developing thyroid cancer.
Signs & Symptoms
Symptoms may vary, and are not unique to thyroid cancer. They include a lump in the neck that gradually increases in size, with or without pain; difficulties swallowing or breathing - this can happen occasionally as a result of the cancer pressing on the esophagus or trachea (windpipe).

Diagnosis & Tests
Diagnosis may involve the following:
  • Having some blood taken to check thyroid hormone levels.
     
  • An ultrasound scan to look at the thyroid and neck and determine whether there are lots of lumps or just one, and whether the lumps are solid or filled with fluid (cysts). A single, solid lump is most likely to be cancer. An ultrasound may also be used to help find the thyroid lump during a needle biopsy.
     
  • A needle biopsy, used to obtain a small amount of thyroid tissue, which can be looked at under a microscope. This is the only way to be sure if a lump is cancer or not.





Conditions that suggest Thyroid Cancer:
Symptoms - Cancer  Thyroid cancer (confirmed)

Risk factors for Thyroid Cancer:
Symptoms - Cancer  History of thyroid cancer

Symptoms - Food - Intake

  High iodine consumption
 Excessive iodine has a complex disruptive effect on the thyroid and may cause an increased risk of thyroid cancer.

Thyroid Cancer suggests the following may be present:
Tumors, Malignant  Cancer, General

Recommendations and treatments for Thyroid Cancer:
Drug  Chemotherapy
 Chemotherapy is not very effective against thyroid cancer. However, doctors may use it to treat thyroid cancer that has spread when other treatments have failed.

  Hydrazine Sulfate
 See the link between Cancer (General) and Hydrazine Sulfate.

Environmental

  Radiation Therapy (Radio Therapy)
 Radiotherapy may be given following surgery to destroy any remaining cancer cells. It may also be used to treat thyroid cancer that has spread to other parts of the body. However, this treatment may not be effective for some types of thyroid cancer.

Surgery/Invasive

  Surgery
 Surgery is the main treatment for thyroid cancer. In most cases, doctors will remove the entire thyroid gland.

Preventive measures against Thyroid Cancer:
MineralNot recommended:
  Iodine
 Excessive iodine has a complex disruptive effect on the thyroid and may, in susceptible individuals, cause an increased risk of getting thyroid cancer.


KEY
Weak or unproven link
Strong or generally accepted link
Proven definite or direct link
May do some good
Likely to help
Highly recommended
May have adverse consequences


GLOSSARY

Biopsy
Removal of a sample of tissue from a living being for diagnosis. A pathologist later uses a microscope to look for certain features, such as cancer cells, in the sample. A fine-needle aspiration biopsy involves inserting a thin needle to remove a small amount of tissue, sometimes using CT or ultrasound to guide the needle. A core biopsy involves obtaining a sample of tissue with a thick needle or by inserting a thin, lighted tube (laparoscope) into a small incision in the abdomen. Another biopsy method is to remove tissue during an operation.

Cancer
Refers to the various types of malignant neoplasms that contain cells growing out of control and invading adjacent tissues, which may metastasize to distant tissues.

Chemotherapy
A treatment of disease by any chemicals. Used most often to refer to the chemical treatments used to combat cancer cells. Chemotherapy is usually given in cycles: a treatment period followed by a recovery period, then another treatment period, and so on. Most anticancer drugs are given by injection into a blood vessel (IV); some are given by mouth. Chemotherapy is a systemic therapy, meaning that the drugs enter the bloodstream and travel throughout the body. Usually, a patient has chemotherapy as an outpatient (at the hospital, at the doctor's office, or at home). However, depending on which drugs are given and the patient's general health, a short hospital stay may be needed.

Cysts (Cyst)
A closed pocket or pouch of tissue; a cyst may form within any tissue in the body and can be filled with air, fluid, pus, or other material. Cysts within the lung generally are air-filled, while cysts involving the lymph system or kidneys are fluid filled. Cysts under the skin are benign, extremely common, movable lumps. These may develop as a result of infection, clogging of sebaceous glands, developmental abnormalities or around foreign bodies.

Esophagus (Esophageal)
Commonly called the "food pipe", it is a narrow muscular tube, about nine and a half inches long, that begins below the tongue and ends at the stomach. It consists of an outer layer of fibrous tissue, a middle layer containing smoother muscle, and an inner membrane, which contains numerous tiny glands. It has muscular sphincters at both its upper and lower ends. The upper sphincter relaxes to allow passage of swallowed food that is then propelled down the esophagus into the stomach by the wave-like peristaltic contractions of the esophageal muscles. There is no protective mucosal layer, so problems can arise when digestive acids reflux into the esophagus from the stomach.

Hormones (Hormone)
Chemical substances secreted by a variety of body organs that are carried by the bloodstream and usually influence cells some distance from the source of production. Hormones signal certain enzymes to perform their functions and, in this way, regulate such body functions as blood sugar levels, insulin levels, the menstrual cycle, and growth. These can be prescription, over-the-counter, synthetic or natural agents. Examples include adrenal hormones such as corticosteroids and aldosterone; glucagon, growth hormone, insulin, testosterone, estrogens, progestins, progesterone, DHEA, melatonin, and thyroid hormones such as thyroxine and calcitonin.

Iodine
A essential mineral that is an integral part of the thyroid hormones, thyroxin and triiodothyronine which have important metabolic roles and govern basal metabolism. The best known iodine deficiency symptom is goiter. Other iodine deficiency problems are reduced vitality, hypothyroidism, inability to think clearly, low resistance to infection, loss of control of the muscles of the mouth resulting in mouth contortion and drooling, defective teeth, tendency to obesity and cretinism which is a congenital abnormal condition marked by physical stunting and mental deficiency.

Radiation Therapy (Radiotherapy)
The use of high-energy rays to kill cancer cells. Depending on the stage of the disease, treatment with radiation may be given alone or with chemotherapy. Radiation therapy is local therapy; it affects cancer cells only in the treated area. External radiation does not cause the body to become radioactive. Most often, treatment is given on an outpatient basis in a hospital or clinic.

Syndrome
A medical condition characterized by a collection of related symptoms (what the patient feels) and signs (what a doctor can observe or measure).

Thyroid (Thyroid Gland)
The thyroid gland is an organ with many veins, anchored around the front of the throat near the voice box. It is essential to normal body growth in infancy and childhood. It absorbs iodine from the diet and releases thyroid hormones - iodine-containing compounds that help govern the rate of the body's metabolism (its total life processes), affecting body temperature, and regulating protein, fat and carbohydrate catabolism in all cells. They keep up growth hormone release, skeletal maturation, and heart rate, force, and output. They promote central nervous system growth, stimulate the making of many enzymes, and are necessary for muscle tone and vigor. To a high degree, metabolism is regulated by the hormone thyroxine, which can be made by the thyroid if enough organic iodine is available. An enlarged thyroid gland that is not cancer is sometimes called goitre.

Trachea
The cartilage tube that brings air from the larynx to the two bronchi that enter the lungs. It is lined with mucous membranes and ciliated epithelia.

Ultrasound
Ultrasound testing uses sound waves projected into the body to produce an image of internal organs, structures, tumors, etc. In this procedure, a gel is applied to the patient's skin, and a small device that emits ultrasonic pulses is slowly passed over the area. The sonic image produced is viewed on a monitor.




Last updated: Sep 28, 2008


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