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Histadelia (Histamine High)
  Histamine High - Histadelia
 Signs, symptoms, indicators
 Conditions that suggest it
 Contributing risk factors
 It could instead be...
 Treatment recommendations
 


Histadelia, more common in males, is characterized by elevated blood levels of histamine. It is estimated that 15-20% of schizophrenics are probably histadelic. This is a disorder, prominent in males, of too much histamine in the blood, as opposed to histapenia in which case there is too little.

Signs & Symptoms


Symptoms include hyperactivity, compulsions, obsessions, inner tensions, blank mind episodes, phobias, chronic depression, and strong suicidal tendencies. Physical signs can include little tolerance for pain, rapid metabolism, lean build, profuse sweating, seasonal allergies, and frequent colds.

Treatment & Prevention
The treatment of histadelia requires great patience because six to ten weeks are often needed before the beginning of significant improvement. The treatment usually takes twelve months to complete.





Signs, symptoms & indicators of Histadelia (Histamine High):
Symptoms - Allergy  Excess mucus
 Histamine can cause additional mucus production.

Symptoms - Environment

  Good tolerance of cold
  Poor tolerance of heat

Counter-indicators:
  Good tolerance of heat
  Poor tolerance of cold

Symptoms - Gas-Int - General

  (Frequent/regular) unexplained nausea

Symptoms - General

  Poor pain tolerance

Counter-indicators:
  Good pain tolerance

Symptoms - Head - Mouth/Oral

  Abundant/excess saliva in mouth

Counter-indicators:
  (Very) dry mouth

Symptoms - Metabolic

  Hyperactivity
 Histamine speeds up metabolism producing a tendency towards hyperactivity.

  Frequent colds/flus

Symptoms - Mind - Emotional

  Phobias

Counter-indicators:
  A lack of phobias

Symptoms - Mind - General

  Being highly motivated
 Those with elevated histamine (histadelics) tend to work compulsively.

  A hard-driving personality
 Histadelics tend to work compulsively.

  Good creativity/imagination
 Histadelics are often highly creative.

Symptoms - Reproductive - General

  Strong sexual desire

Counter-indicators:
  Weak sexual desire

Symptoms - Skeletal

  Joint pain/swelling/stiffness

Symptoms - Skin - General

  Excess perspiration
  Warm skin

Conditions that suggest Histadelia (Histamine High):
Allergy  Allergic Rhinitis / Hay Fever

Mental

  Depression
 Histadelics are often chronically and suicidally depressed.

  Obsessive-Compulsive Disorder (OCD)
 Histadelics are often prone to obsessions, compulsions, and addictions.

Metabolic

  Addictions / Addictive Tendencies
 Nutritional treatment for drug and alcohol users will depend on the results of a test for blood histamine levels. In one series of such analysis, all users proved to have high histamine levels, leading the scientist to conclude that this abnormality - with its impact on brain function - is a major force in creating addiction. [Nutrition Guide for the Prevention and Cure of Common Ailments and Diseases, Carlton Fredericks, PhD. p.58]

  Headaches
  Insomnia
 The overarousal seen in histadelia may contribute to insomnia.

Musculo-Skeletal

  Muscle Pains (Myalgia)

Risk factors for Histadelia (Histamine High):
Symptoms - Skeletal  Slender fingers / toes
 Histadelics often have long fingers and toes.


Counter-indicators:
  Stubby fingers / toes
 Histadelics often have long fingers and toes.

Histadelia (Histamine High) could instead be:
Mental  Schizophrenia
 Histadelia is estimated to affect 15-20% of patients classified as "schizophrenic".

Recommendations and treatments for Histadelia (Histamine High):
Amino Acid / Protein  Methionine
 Methionine supplements lower blood levels of histamine by increasing histamine breakdown.

Diet

  Plant-Based Nutrition
 Nutritionists recommend a low-protein, high complex carbohydrate diet. Histidine, which is more common in animal proteins, should be avoided as it can be converted into histamine.

Lab Tests/Rule-Outs

  Test Histamine Levels
  Test Copper Levels
 Testing serum or hair copper levels is usually adequate for evaluating copper status when low levels of copper are suspected and hair contamination with copper can be ruled out. When in doubt, it would be better to use more accurate tests such as the 24 hour urine copper or serum ceruloplasmin.

  Test Folic Acid Levels
 Under certain conditions, such as anticipated or actual pregnancy, a simple lab test for serum folate levels is advisable. If the test results show low levels, supplementation should be considered to prevent potential birth defects.

  Test Zinc Levels
  Test for Manganese Levels

Mineral

  Calcium
  Copper
 Copper levels may be low to normal in patients with histadelia. Copper is part of the enzyme histaminase, which is involved in the metabolism of histamine.

  Magnesium
  Manganese

Vitamins

  Vitamin B6 (Pyridoxine)
  Vitamin C (Ascorbic Acid)

Not recommended:
  Folic Acid
 Histadelics should avoid supplemental folic acid as it can produce excess histamine. In fact, anti-folate drugs may be required. Folic acid increases depression in histadelic patients and a trial of folic acid could be used to distinguish between histapenics and histadelics. In extreme cases, folic acid in food or in multivitamins is enough to produce the adverse effects.


KEY
Weak or unproven link
Strong or generally accepted link
Weakly counter-indicative
Strongly counter-indicative
May do some good
Likely to help
Highly recommended
Reasonably likely to cause problems


GLOSSARY

Allergy (Allergies)
Hypersensitivity caused by exposure to a particular antigen (allergen), resulting in an increased reactivity to that antigen on subsequent exposure, sometimes with harmful immunologic consequences.

Chronic (Chronicity)
Usually referring to chronic illness: Illness extending over a long period of time.

Complex Carbohydrate (Complex Carbohydrates)
Includes indigestible molecules of fiber (e.g. starch and glycogen). Slowly releases sugar into the bloodstream and also adds the fiber.

Copper
An essential mineral that is a component of several important enzymes in the body and is essential to good health. Copper is found in all body tissues. Copper deficiency leads to a variety of abnormalities, including anemia, skeletal defects, degeneration of the nervous system, reproductive failure, pronounced cardiovascular lesions, elevated blood cholesterol, impaired immunity and defects in the pigmentation and structure of hair. Copper is involved in iron incorporation into hemoglobin. It is also involved with vitamin C in the formation of collagen and the proper functioning in central nervous system. More than a dozen enzymes have been found to contain copper. The best studied are superoxide dismutase (SOD), cytochrome C oxidase, catalase, dopamine hydroxylase, uricase, tryptophan dioxygenase, lecithinase and other monoamine and diamine oxidases.

Enzymes (Enzyme)
Specific protein catalysts produced by the cells that are crucial in chemical reactions and in building up or synthesizing most compounds in the body. Each enzyme performs a specific function without itself being consumed. For example, the digestive enzyme amylase acts on carbohydrates in foods to break them down.

Folic Acid
A B-complex vitamin that functions along with vitamin B-12 and vitamin C in the utilization of proteins. It has an essential role in the formation of heme (the iron containing protein in hemoglobin necessary for the formation of red blood cells) and DNA. Folic acid is essential during pregnancy to prevent neural tubular defects in the developing fetus.

Histamine
A chemical in the body tissues, produced by the breakdown of histidine. It is released in allergic reactions and causes widening of capillaries, decreased blood pressure, increased release of gastric juice, fluid leakage forming itchy skin and hives, and tightening of smooth muscles of the bronchial tube and uterus. Histamine is the chemical that drives the initial acute allergic reaction, causing itching, swelling and congestion.

Histidine
An amino acid. Precursor to histamine, a vasodilator and gastric juice stimulant. Has been used as a therapeutic aid for arthritis.

Metabolism (Metabolic, Metabolize, Metabolizes, Metabolizing)
The chemical processes of living cells in which energy is produced in order to replace and repair tissues and maintain a healthy body. Responsible for the production of energy, biosynthesis of important substances, and degradation of various compounds. Also defined as the sum total of changes in an organism in order to achieve a balance (homeostasis): Catabolic burns up, anabolic stores and builds up; the sum of their work is metabolism.

Methionine
Essential amino acid. Dietary source of sulfur and methyl groups. Important for proper growth in infants, nitrogen balance in adults, healthy nails and skin and the synthesis of taurine, cysteine, phosphatidylcholine (lecithin), bile, carnitine and endorphins. It is an antioxidant nutrient and lipotropic agent which promotes the physiological utilization of fat.

Mucus (Mucous)
The viscous, slippery substance that consists chiefly of mucin, water, cells, and inorganic salts and is secreted as a protective lubricant coating by cells and glands of the mucous membranes.

Protein (Proteins)
Compounds composed of hydrogen, oxygen, and nitrogen present in the body and in foods that form complex combinations of amino acids. Protein is essential for life and is used for growth and repair. Foods that supply the body with protein include animal products, grains, legumes, and vegetables. Proteins from animal sources contain the essential amino acids. Proteins are changed to amino acids in the body.

Serum
The cell-free fluid of the bloodstream. It appears in a test tube after the blood clots and is often used in expressions relating to the levels of certain compounds in the blood stream.




Last updated: May 11, 2008


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