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Histadelia (Histamine High): Overview
Histadelia, more common in males, is characterized by elevated blood levels of histamine. It is estimated that 15-20% of schizophrenics are probably histadelic.
This is a disorder, prominent in males, of too much histamine in the blood, as opposed to histapenia in which case there is too little.
Signs and Symptoms
Symptoms include hyperactivity, compulsions, obsessions, inner tensions, blank mind episodes, phobias, chronic depression, and strong suicidal tendencies. Physical signs can include little tolerance for pain, rapid metabolism, lean build, profuse sweating, seasonal allergies, and frequent colds.
Treatment and Prevention
The treatment of histadelia requires great patience because six to ten weeks are often needed before the beginning of significant improvement. The treatment usually takes twelve months to complete.
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Signs, symptoms & indicators of Histadelia (Histamine High):
Conditions that suggest Histadelia (Histamine High): | | | | | Allergy |  Allergic Rhinitis / Hay Fever |
Mental |
Depression | Histadelics are often chronically and suicidally depressed. |
Obsessive-Compulsive Disorder (OCD) | Histadelics are often prone to obsessions, compulsions, and addictions. |
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Metabolic |
Addictions / Addictive Tendencies | Nutritional treatment for drug and alcohol users will depend on the results of a test for blood histamine levels. In one series of such analysis, all users proved to have high histamine levels, leading the scientist to conclude that this abnormality - with its impact on brain function - is a major force in creating addiction. [Nutrition Guide for the Prevention and Cure of Common Ailments and Diseases, Carlton Fredericks, PhD. p.58] |
 Headaches
Insomnia | The overarousal seen in histadelia may contribute to insomnia. |
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Musculo-Skeletal |
Muscle Pains (Myalgia) |
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Risk factors for Histadelia (Histamine High):
Histadelia (Histamine High) could instead be:
Recommendations and treatments for Histadelia (Histamine High): | | | | | Amino Acid / Protein |  Methionine |
Diet |
 Plant-Based Nutrition |
Lab Tests/Rule-Outs |
Test Histamine Levels
Test Copper Levels | Testing serum or hair copper levels is usually adequate for evaluating copper status when low levels of copper are suspected and hair contamination with copper can be ruled out. When in doubt, it would be better to use more accurate tests such as the 24 hour urine copper or serum ceruloplasmin. |
Test Folic Acid Levels | Under certain conditions, such as anticipated or actual pregnancy, a simple lab test for serum folate levels is advisable. If the test results show low levels, supplementation should be considered to prevent potential birth defects. |
Test Zinc Levels
Test for Manganese Levels |
Mineral |
 Calcium
Copper | Copper levels may be low to normal in patients with histadelia. Copper is part of the enzyme histaminase, which is involved in the metabolism of histamine. |
Magnesium
Manganese |
Vitamins |
Vitamin B6 (Pyridoxine)
Vitamin C (Ascorbic Acid)
Not recommended:
 Folic Acid | Histadelics should avoid supplemental folic acid as it can produce excess histamine. In fact, anti-folate drugs may be required. Folic acid increases depression in histadelic patients and a trial of folic acid could be used to distinguish between histapenics and histadelics. In extreme cases, folic acid in food or in multivitamins is enough to produce the adverse effects. |
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KEY | Weak or unproven link: may be a sign or symptom of; may suggest | | Strong or generally accepted link: is often a sign or symptom of; often suggests; often increases risk of; is sometimes misdiagnosed as |  | Weakly counter-indicative: may contraindicate |  | Strong counter-indication: often contraindicates; often decreases risk of | | May be useful: may help with | | Moderately useful: often helps with | | Very useful: is highly recommended for | | Often counterindicated: is often not recommended for |
Last updated: Mar 13, 2012
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