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Werners Syndrome
  Werners Syndrome
 It could instead be...
 


Werners syndrome (WS), a rare familial disease with symptoms resembling premature aging, is considered a partial model of human aging. Causes & Development


The gene responsible for WS (known as WRN) has been identified (and even cloned) by National Institute on Aging-funded researchers [Yu et al., Science 4/12/96] as one that produces an enzyme involved in DNA metabolism and repair. Several signs of defective DNA metabolism have been identified in cells obtained from WS patients. The consequences of the defective WRN gene may be related to the accumulation of DNA damage in the cells of people with WS leading to the premature development of age-related diseases.

Signs & Symptoms
Sufferers of WS have a generally aged appearance including early graying, loss of hair, and skin wrinkling.

Complications
People with WS develop a vast array of age-related diseases including arteriosclerosis, malignant neoplasms, cancer, type II diabetes mellitus, ocular cataracts and osteoporosis in early adult life.





Werners Syndrome could instead be:
Aging  Premature/Signs of Aging
 The symptoms of Werners Syndrome closely resemble premature aging.


KEY
Weak or unproven link


GLOSSARY

Arteriosclerosis
A common arterial disorder. Characterized by calcified yellowish plaques, lipids, and cellular debris in the inner layers of the walls of large and medium-sized arteries.

Cancer
Refers to the various types of malignant neoplasms that contain cells growing out of control and invading adjacent tissues, which may metastasize to distant tissues.

Cataract (Cataracts)
A steadily worsening disease of the eye in which the lens becomes cloudy as a result of the precipitation of proteins. Most cataracts are caused by the functions of the body breaking down. Eye trauma, such as from a puncture wound, may also result in cataracts.

Diabetes Mellitus (Diabetes, Diabetic, Diabetics)
A disease with increased blood glucose levels due to lack or ineffectiveness of insulin. Diabetes is found in two forms; insulin-dependent diabetes (juvenile-onset) and non-insulin-dependent (adult-onset). Symptoms include increased thirst; increased urination; weight loss in spite of increased appetite; fatigue; nausea; vomiting; frequent infections including bladder, vaginal, and skin; blurred vision; impotence in men; bad breath; cessation of menses; diminished skin fullness. Other symptoms include bleeding gums; ear noise/buzzing; diarrhea; depression; confusion.

DNA
Deoxyribonucleic acid, the large molecule that is the main carrier of genetic information in cells. DNA is found mainly in the chromosomes of cells.

Enzymes (Enzyme)
Specific protein catalysts produced by the cells that are crucial in chemical reactions and in building up or synthesizing most compounds in the body. Each enzyme performs a specific function without itself being consumed. For example, the digestive enzyme amylase acts on carbohydrates in foods to break them down.

Malignant (Cancerous)
Dangerous. Mainly used to describe a cancerous growth -- when used this way, it means the growth is cancerous and predisposed to spreading.

Metabolism (Metabolic, Metabolize, Metabolizes, Metabolizing)
The chemical processes of living cells in which energy is produced in order to replace and repair tissues and maintain a healthy body. Responsible for the production of energy, biosynthesis of important substances, and degradation of various compounds. Also defined as the sum total of changes in an organism in order to achieve a balance (homeostasis): Catabolic burns up, anabolic stores and builds up; the sum of their work is metabolism.

Osteoporosis
A disease in which bone tissue becomes porous and brittle. The disease primarily affects postmenopausal women.

Syndrome
A medical condition characterized by a collection of related symptoms (what the patient feels) and signs (what a doctor can observe or measure).




Last updated: Apr 13, 2008


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