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Chemotherapy Side-Effects
  Chemotherapy, Side-Effects Of
 Signs, symptoms, indicators
 Conditions that suggest it
 Contributing risk factors
 It can lead to...
 Treatment recommendations
 


Chemotherapy is the use of drugs to destroy cancer cells. Chemotherapy works by destroying very active cancer cells that grow rapidly. Unfortunately, chemotherapy also effects normal cells that grow rapidly such as blood cells forming in the bone marrow, cells in the hair follicles, or cells in the mouth and intestines.





Signs, symptoms & indicators of Chemotherapy Side-Effects:
Symptoms - Nails  Black/brown fingernails
 Black line(s) across the nails are common in dark-skinned persons but may also be the result of injury or chemotherapy.

Conditions that suggest Chemotherapy Side-Effects:
Circulation  Megaloblastic Anemia / Pernicious Anemia
 Some chemotherapy agents are known inhibitors of folic acid enzymes and as such can induce a megaloblastic anemia.

Digestion

  Increased Intestinal Permeability / Leaky Gut

Immunity

  Weakened Immune System

Lab Values

  Low White Count
 Radiation therapy and chemotherapy destroy fast-growing cells such as white blood cells. Patients receiving a combination of radiation therapy and chemotherapy are at greater risk of a low white count.

Risk factors for Chemotherapy Side-Effects:
Symptoms - Cancer  Recent/past chemotherapy use

Chemotherapy Side-Effects can lead to:
Circulation  Megaloblastic Anemia / Pernicious Anemia
 Some chemotherapy agents are known inhibitors of folic acid enzymes and as such can induce a megaloblastic anemia.

Digestion

  Increased Intestinal Permeability / Leaky Gut

Immunity

  Weakened Immune System

Lab Values

  Low White Count
 Radiation therapy and chemotherapy destroy fast-growing cells such as white blood cells. Patients receiving a combination of radiation therapy and chemotherapy are at greater risk of a low white count.

Recommendations and treatments for Chemotherapy Side-Effects:
Amino Acid / Protein  Glutamine
 Several studies have shown that glutamine, when used as an oral rinse, can help to reduce cancer chemotherapy-induced mouth sores.


KEY
Weak or unproven link
Strong or generally accepted link
Proven definite or direct link
Likely to help


GLOSSARY

Anemia (Anaemia, Anemias)
A condition resulting from an unusually low number of red blood cells or too little hemoglobin in the red blood cells. The most common type is iron-deficiency anemia in which the red blood cells are reduced in size and number, and hemoglobin levels are low. Clinical symptoms include shortness of breath, lethargy and heart palpitations.

Cancer
Refers to the various types of malignant neoplasms that contain cells growing out of control and invading adjacent tissues, which may metastasize to distant tissues.

Chemotherapy
A treatment of disease by any chemicals. Used most often to refer to the chemical treatments used to combat cancer cells. Chemotherapy is usually given in cycles: a treatment period followed by a recovery period, then another treatment period, and so on. Most anticancer drugs are given by injection into a blood vessel (IV); some are given by mouth. Chemotherapy is a systemic therapy, meaning that the drugs enter the bloodstream and travel throughout the body. Usually, a patient has chemotherapy as an outpatient (at the hospital, at the doctor's office, or at home). However, depending on which drugs are given and the patient's general health, a short hospital stay may be needed.

Enzymes (Enzyme)
Specific protein catalysts produced by the cells that are crucial in chemical reactions and in building up or synthesizing most compounds in the body. Each enzyme performs a specific function without itself being consumed. For example, the digestive enzyme amylase acts on carbohydrates in foods to break them down.

Folic Acid
A B-complex vitamin that functions along with vitamin B-12 and vitamin C in the utilization of proteins. It has an essential role in the formation of heme (the iron containing protein in hemoglobin necessary for the formation of red blood cells) and DNA. Folic acid is essential during pregnancy to prevent neural tubular defects in the developing fetus.

Glutamine
A "conditionally essential" amino acid, glutamine is considered to be a brain fuel. Glutamine has been used therapeutically for alcoholism, mild depression and to reduce the craving for sweets. Glutamine is very important in the functioning of the metabolism and muscle maintenance. Glutamine supplementation can help prevent muscle and other tissue breakdown by providing the body with nitrogen and fuel.

Megaloblast (Megaloblastic, Megaloblasts)
An abnormally large nucleated red blood cell found especially in people having pernicious anemia or certain vitamin deficiencies.

Radiation Therapy (Radiotherapy)
The use of high-energy rays to kill cancer cells. Depending on the stage of the disease, treatment with radiation may be given alone or with chemotherapy. Radiation therapy is local therapy; it affects cancer cells only in the treated area. External radiation does not cause the body to become radioactive. Most often, treatment is given on an outpatient basis in a hospital or clinic.

White Blood Cell (WBC, White Blood Cells)
A blood cell that does not contain hemoglobin: a blood corpuscle responsible for maintaining the body's immune surveillance system against invasion by foreign substances such as viruses or bacteria. White cells become specifically programmed against foreign invaders and work to inactivate and rid the body of a foreign substance. White blood cells are composed primarily of neutrophils, monocytes and lymphocytes. Lymphocytes are either T-cells or B-cells. T-cells (CD3 cells) are divided into T-helper (CD4 cells) and T-suppressor/cytotoxic (CD8 cells) cells.




Last updated: Jun 28, 2008


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