 Signs, symptoms & indicators of Uric Acid Levels Low:
Conditions that suggest Uric Acid Levels Low: | |  | | | Autoimmune |  Multiple Sclerosis | It has been proposed - and research is supporting the idea - that low uric acid levels are associated with increased frequency and longer bouts of multiple sclerosis. Uric acid works by inactivating peroxynitrite, a toxic compound that may cause damage to the central nervous system in MS patients. Researchers report that they found lower levels of uric acid in the blood of MS patients than of people without the disease. It appears that high serum uric acid levels protect against the development of MS. These results raise the possibility that the natural biologic product, uric acid, or a more soluble peroxynitrite scavenger that penetrates the blood brain-barrier more readily might have clinical utility in the treatment of MS. [Proceedings of the National Academy of Sciences 1998;95: pp.675-680] |
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Risk factors for Uric Acid Levels Low: | | | | | Nutrients |  Molybdenum Need| | Xanthine oxidase, the enzyme that immediately produces uric acid, uses molybdenum as a cofactor. Molybdenum is known to raise uric acid levels, which is why people with gout (a condition of elevated high uric acid levels) are told to avoid molybdenum supplements. |
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Uric Acid Levels Low can lead to: | | | | | Autoimmune |  Multiple Sclerosis| | It has been proposed - and research is supporting the idea - that low uric acid levels are associated with increased frequency and longer bouts of multiple sclerosis. Uric acid works by inactivating peroxynitrite, a toxic compound that may cause damage to the central nervous system in MS patients. Researchers report that they found lower levels of uric acid in the blood of MS patients than of people without the disease. It appears that high serum uric acid levels protect against the development of MS. These results raise the possibility that the natural biologic product, uric acid, or a more soluble peroxynitrite scavenger that penetrates the blood brain-barrier more readily might have clinical utility in the treatment of MS. [Proceedings of the National Academy of Sciences 1998;95: pp.675-680] |
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Recommendations and treatments for Uric Acid Levels Low: | | | | | Lab Tests/Rule-Outs |  Test Copper Levels |
Mineral |
Molybdenum| | Uric acid levels can be raised with supplemental molybdenum. While taking molybdenum orally may raise uric acid levels, IV administration may be required in some cases. Further evidence of an interaction comes from a study of men who consumed 10 to 15mg of molybdenum per day for prolonged periods who then developed high serum uric acid levels. |
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Vitamins |
 Vitamin B3 (Niacin) |
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KEY | | Weak or unproven link | | | Strong or generally accepted link | | | Proven definite or direct link |  | | Very strongly or absolutely counter-indicative | | | Likely to help | | | Highly recommended |
GLOSSARY
Antioxidant (Antioxidants)
A chemical compound that slows or prevents oxygen from reacting with other compounds. Some antioxidants have been shown to have cancer-protecting potential because they neutralize free radicals. Examples include vitamins C and E, beta carotene, the minerals selenium and germanium, superoxide dismutase (SOD), coenzyme Q10, catalase, and some amino acids.
Central Nervous System (CNS)
A collective term for the brain, spinal cord, their nerves, and the sensory end organs. More broadly, this can even include the
neurotransmitting hormones instigated by the CNS that control the chemical nervous system, the endocrine glands.
Cofactor (Cofactors)
A substance that acts with another substance to bring about certain effects, often a coenzyme.
Copper
An essential mineral that is a component of several important enzymes in the body and is essential to good health. Copper is found in all body tissues. Copper deficiency leads to a variety of abnormalities, including anemia, skeletal defects, degeneration of the nervous system, reproductive failure, pronounced cardiovascular lesions, elevated blood cholesterol, impaired immunity and defects in the pigmentation and structure of hair. Copper is involved in iron incorporation into hemoglobin. It is also involved with vitamin C in the formation of collagen and the proper functioning in central nervous system. More than a dozen enzymes have been found to contain copper. The best studied are superoxide dismutase (SOD), cytochrome C oxidase, catalase, dopamine hydroxylase, uricase, tryptophan dioxygenase, lecithinase and other monoamine and diamine oxidases.
Enzymes (Enzyme)
Specific protein catalysts produced by the cells that are crucial in chemical reactions and in building up or synthesizing most compounds in the body. Each enzyme performs a specific function without itself being consumed. For example, the digestive enzyme amylase acts on carbohydrates in foods to break them down.
Gout
A disease characterized by an increased blood uric acid level and sudden onset of episodes of acute arthritis.
Intravenous Infusion (IV)
A small needle placed in the vein to assist in fluid replacement or the giving of medication.
Milligram (mg, Milligrams)
0.001 or a thousandth of a gram.
Molybdenum
An essential trace element. It helps regulate iron stores in the body and is a key component of at least three enzymes: xanthine oxidase, aldehyde oxidase and sulfite oxidase. These enzymes are involved with carbohydrate metabolism, fat oxidation and urine metabolism. The average adult has about 9mg of molybdenum concentrated mostly in the liver, kidney, adrenal glands, bones and skin. Molybdenum deficiencies are associated with esophageal cancer, sexual impotency and tooth decay.
Multiple Sclerosis (MS)
Demyelinating disorder of the central nervous system, causing patches of sclerosis (plaques) in the brain and spinal cord, manifested by loss of normal neurological functions, e.g. muscle weakness, loss of vision, and mood alterations.
Serum
The cell-free fluid of the bloodstream. It appears in a test tube after the blood clots and is often used in expressions relating to the levels of certain compounds in the blood stream.
Uric Acid (Hyperuricemia)
The final end product of certain native or dietary proteins, especially the nucleoproteins found in the nucleus of cells. Unlike the much smaller nitrogenous waste product urea, which is mostly recycled to form many amino acids, uric acid is an unrecycleable metabolite that must be excreted: nucleoprotein to purine to uric acid to the outside in the urine or the sweat. Hyperuricemia: Having elevated blood uric acid, either from a rapid rate of cell breakdown and synthesis (such as might occur from fasting, heavy training, trauma or any number of major diseases), a high consumption of organ meats, glandular supplements or spirulina, or the inability (usually hereditary) to excrete uric acid in the urine as fast as it is produced, even though production itself is not elevated.
Last updated: Apr 13, 2008
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