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Alcohol-related Problems
  Alcohol, Consequences Of / Alcoholism
 Signs, symptoms, indicators
 Conditions that suggest it
 Contributing risk factors
 It can lead to...
 Treatment recommendations
 Prevention
 


Alcoholism is the physical and emotional dependency on the use of alcohol, the removal of which causes physical and emotional withdrawal symptoms. Although two-thirds of American men and one-half of American women drink alcohol, three-fourths of drinkers experience no serious consequences from alcohol use.

Repeated studies of alcoholics have confirmed that it is almost invariably fear which drives an alcoholic to seek help; fear for his safety, health, or sanity; fear of loss of love, family, home or job. An event ferocious enough, frightening enough, appalling enough, or humiliating enough happens to breech his denial system. But the defenses of the mind are like those of the body; they rush to wall off, to localize and repair damage. No sooner has the alcoholic faced the magnitude and malignancy of his drinking problem than the denial begins to build again and he begins to temporize. As paradoxical as it seems, therefore, the first phase in any treatment approach to the alcoholic, even the alcoholic who has specifically presented himself to obtain help with his drinking problem, must center on his being confronted with the inescapable fact of his alcoholism. He must be repeatedly reminded he is an alcoholic, that he is no different from other alcoholics in his vulnerability to alcohol, and that his feelings of imperviousness to relapse are not justified. Even with persistent confrontations, it may take 3-6 months before the alcoholic's efforts to rebuild his denial system taper off, and this will be the time of greatest danger that he will drop back out of treatment.

Causes & Development; Risk Factors


The physical dependence element develops at different rates for different individuals and effects vary widely. Any human who drinks enough alcohol over enough time will become alcoholic. For some, it takes large quantities and long periods and for others, small quantities and short periods. It is difficult to predict where any given individual may be on that scale.

Genetic predisposition to easy development of alcoholism is evidenced in differing proportions in differing ethnic groups.

Signs & Symptoms
There are many symptoms of chronic alcoholism. The main ones include:
  • Denying the problem
  • Tremors
  • Blackouts
  • Mood swings upon ingestion
  • Protecting supply (many alcoholics can hold a job long after they have lost everything else, including their family)
  • A loved one or associate telling the patient they drink too much
  • Gulping drinks
  • Hiding supply
Treatment & Prevention
Alcoholics Anonymous, made up of recovering alcoholics, is as successful as any treatment program and there is no fee.

Prognosis
Amongst those who abuse alcohol, many reduce their drinking without formal treatment after personal reflection about negative consequences. However, the recovery rate is often poor even among people who seek help.





Signs, symptoms & indicators of Alcohol-related Problems:
Lab Values - Cells  Macrocytic red cells

Symptoms - Food - Beverages

  No desire/inability to recover from alcoholism or being a recovering alcoholic (confirmed)

Symptoms - Head - Nose

  An enlarged nose
 Rhinophyma (an enlarged nose) has been associated with several causes including the over-consumption of alcohol. Men are 12 times more likely to have this problem than women.

Symptoms - Mind - General

  Short-term memory failure
 Alcoholics as well as the elderly suffer gradual loss of acetylcholine, a vital neurotransmitter. The brain compensates for this change by heightening the sensitivity of the receptors carrying memory messages, but because of the acetylcholine shortage, the transmission cannot be completed and short-term recall is poor.

Conditions that suggest Alcohol-related Problems:
Digestion  Increased Intestinal Permeability / Leaky Gut

Hormones

  Low Sex Drive

Infections

  Yeast / Candida Infection
 Alcohol kills friendly bacteria, increases toxic overload of the liver and thus allows Candida to grow.

Lab Values

  High Levels Of Triglycerides

Mental

  Senile Dementia
 Alcoholism is a possible cause of senile dementia.

Metabolic

  Edema (Water Retention)
 Excessive alcohol intake can cause edema,

  Insomnia
 Depletion of tryptophan as a result of heavy drinking explains why alcoholics suffer from insomnia.

  Hemochromatosis (Iron overload)
 Use of alcohol and other hepatotoxic drugs lowers the ability of the liver to safely store iron and may accelerate the development of the liver changes seen with hemochromatosis.

Nutrients

  Magnesium Requirement
 People who abuse alcohol are at high risk for magnesium deficiency because alcohol increases urinary excretion of magnesium. Low blood levels of magnesium occur in 30-60% of alcoholics, and in nearly 90% of patients experiencing alcohol withdrawal. In addition, alcoholics who substitute alcohol for food will usually have lower magnesium intakes. Medical doctors routinely evaluate the need for extra magnesium in this population.

  Increased Folic Acid Requirement
 Alcohol interferes with the metabolism and absorption of folic acid.

  Vitamin B1 Requirement
 Alcoholics are at significantly increased risk of developing a deficiency of thiamine (vitamin B1) and may develop a form of thiamine deficiency called wet beri beri.

  Zinc Requirement
 Zinc deficiency is frequently associated with alcoholism, due to a lower intake of food.

  Multiple Vitamin Need
 An interesting study showed significantly decreased levels of anxiety among a group of alcoholics treated with megavitamins. Over a 21-day period, the group took approximately 3gm of vitamin C, 3gm of niacin, 600mg of B6, and 600 IU of vitamin E per day. A comparison group received only inert gelatin capsules. None of the subjects in either group took antidepressants or antianxiety drugs. Anxiety levels among both groups were measured three times over the 21 days. They fell dramatically only in the group on megavitamin therapy.

Organ Health

  Cirrhosis of the Liver
 To many people, cirrhosis of the liver is synonymous with chronic alcoholism. It is a major cause, but nevertheless one of several. Alcoholic cirrhosis usually develops after more than a decade of heavy drinking. The amount of alcohol that can injure the liver varies from person to person. In women, as few as two to three drinks per day have been linked with cirrhosis and in men, as few as three to four drinks per day. Alcohol seems to injure the liver by blocking the normal metabolism of protein, fats and carbohydrates.

Respiratory

  Pneumonia
 Alcoholism is a risk factor for the development of pneumonia.

Symptoms - Food - Beverages

  Alcoholism (confirmed)

Tumors, Malignant

  Breast Cancer
 Since the original recommendation regarding alcohol was published, researchers at the Harvard Medical School found that even 3 drinks a week put women at increased risk for breast cancer. Women who had one or more drinks a day were found to be at 60% higher risk than women who did not drink.

  Esophageal Cancer
 If you are a smoker then heavy alcohol consumption can increase risk of esophageal cancer by 25% to 50%.

  Laryngeal Cancer
 In smokers, heavy alcohol consumption increases the risk of laryngeal cancer by approximately 75%.

Risk factors for Alcohol-related Problems:
Lab Values - Chemistries  Excellent HDL level
 Elevated levels of HDL cholesterol are generally considered to have a protective effect against cardiovascular disease. However, very elevated levels can be a result of liver disease or chronic intoxication.

Metabolic

  Pyroluria
 When anxiety is a factor promoting the consumption of alcohol, Pyroluria should be investigated as a possibility. As many as one-third to one-half of alcoholics have this genetic chemical imbalance.

Nutrients

  EFA (Essential Fatty Acid) Type 3 Requirement
 Polyunsaturated omega-3 fatty acid deficiency may contribute to depressive symptoms in alcoholism, multiple sclerosis and postpartum depression.

Symptoms - Food - Beverages

  Moderate/high alcohol consumption

Counter-indicators:
  Being a recovered alcoholic
  Very low alcohol consumption or never having consumed alcohol
  Complete alcohol avoidance (confirmed)

Alcohol-related Problems can lead to:
Circulation  Aneurysm / Rupture
 See the link between Smoke Damage and Aneurysm.

  Cardiomyopathy
 Cardiomyopathy occurs with greater frequency in people who drink too much alcohol. The risk of developing DCM is greater for female than for male alcoholics [JAMA 1995;274(2): pp.149-54]. Alcoholics can develop a form of thiamine deficiency called wet beri beri or Shoshin beri beri, which frequently includes cardiomyopathy.

Digestion

  Increased Intestinal Permeability / Leaky Gut

Hormones

  Low Sex Drive

Metabolic

  Insomnia
 Depletion of tryptophan as a result of heavy drinking explains why alcoholics suffer from insomnia.

Nutrients

  Magnesium Requirement
 People who abuse alcohol are at high risk for magnesium deficiency because alcohol increases urinary excretion of magnesium. Low blood levels of magnesium occur in 30-60% of alcoholics, and in nearly 90% of patients experiencing alcohol withdrawal. In addition, alcoholics who substitute alcohol for food will usually have lower magnesium intakes. Medical doctors routinely evaluate the need for extra magnesium in this population.

  Multiple Vitamin Need
 An interesting study showed significantly decreased levels of anxiety among a group of alcoholics treated with megavitamins. Over a 21-day period, the group took approximately 3gm of vitamin C, 3gm of niacin, 600mg of B6, and 600 IU of vitamin E per day. A comparison group received only inert gelatin capsules. None of the subjects in either group took antidepressants or antianxiety drugs. Anxiety levels among both groups were measured three times over the 21 days. They fell dramatically only in the group on megavitamin therapy.

  Vitamin B1 Requirement
 Alcoholics are at significantly increased risk of developing a deficiency of thiamine (vitamin B1) and may develop a form of thiamine deficiency called wet beri beri.

  Zinc Requirement
 Zinc deficiency is frequently associated with alcoholism, due to a lower intake of food.

Recommendations and treatments for Alcohol-related Problems:
Botanical  Chlorella

Not recommended:
  Kava

Diet

  Raw Food Diet
 In a study where the average intake of uncooked food comprised 62% of calories ingested, 80% of those who drank alcohol abstained spontaneously. [South Med J 1985 Jul;78(7): pp.841-4]

  Therapeutic Fasting
 Fasting makes it easier to overcome bad habits and addictions. Many people have overcome tobacco and alcohol addictions, and even drug addictions, by fasting. Fasting rapidly dissipates the craving for alcohol.

Drug

  GHB (Gamma-Hydroxybutyrate)
 GHB shows great promise in the treatment of alcoholism. In Europe, one of its primary uses is to relieve withdrawal symptoms, cravings and anxiety among alcoholics.

In a rigorous, double-blind, placebo-controlled study conducted on alcoholics, “...nearly all withdrawal symptoms disappeared within 2-7 hours” after administration of GHB. On a severe-moderate-mild-or-none scale, withdrawal symptoms remained below moderate during the entire period. The only side-effect observed was slight, occasional and transient dizziness. The researchers concluded, “...the results clearly indicated that GHB is effective for the suppression of withdrawal symptoms in alcoholics” [Gallimberti, 1989].

  Conventional Drug Avoidance
 It can be dangerous to drink if you are taking prescription or over-the-counter medications. Medication that slows you down or sedates you can be very dangerous when combined with alcohol. You might find you have difficulty breathing and a great deal of difficulty thinking clearly. You need to be careful with the following drugs:
  • Barbiturates, which should never be taken with alcohol
  • Benzodiazepines, such as Valium or Halcion
  • Codeine
  • Anti-histamines, which are often taken for allergies and colds
  • Some painkillers, which can combine with alcohol to damage the stomach lining and cause bleeding
  • Anti-depressants, such as Prozac


Not recommended:
  Aspirin
 Aspirin can prevent stomach enzymes from processing the alcohol. If taking aspirin, leave more time between drinks so the liver can cope.

  Antibiotics
 Some antibiotics do not work well when combined with alcohol.

Lab Tests/Rule-Outs

  Test Zinc Levels
 It is clear that brain zinc content changes during disease states and that brain zinc deficiency is possibly dynamically related to alcoholism. McLardy (1973) observed a 30% deficit in brain zinc levels amongst chronic alcoholics.

  Test for Manganese Levels
  Test for Urine Kryptopyrroles
  Test Copper Levels

Mineral

  Zinc
 Low zinc status has been observed in 30% to 50% of alcoholics. Alcohol decreases the absorption of zinc and increases loss of zinc in urine. In addition, many alcoholics do not eat an acceptable variety or amount of food, so their dietary intake of zinc may be inadequate.

Nutrient

  Alpha Lipoic Acid
 Alpha-lipoic acid should not be given in high doses to patients suspected of having a thiamine deficiency unless the thiamine deficiency is also corrected. Individuals who may be deficient in vitamin B1 (such as alcoholics) should supplement vitamin B1 along with alpha-lipoic acid.

Psychological

  Alcoholics Anonymous (AA)

Vitamins

  Vitamin B-Complex
 Regular use of a quality high potency multiple vitamin may be important in alcoholism. Alcoholics are classically deficient in most of the B vitamins. These deficiencies result from a variety of mechanisms: low dietary intake, deactivation of the active form, impaired conversion to the active form by ethanol or acetaldehyde, impaired absorption, and decreased storage capacity. A thiamine deficiency is both the most common and the most serious of the B-vitamin deficiencies, since a deficiency causes beriberi and the Wernicke-Korsakoff Syndrome. A functional pyridoxine deficiency is also common in alcoholics, due not so much to inadequate intake as impaired conversion to its active form, pyridoxal-5-phosphate, and enhanced degradation.

  Vitamin B1 (Thiamine)
  Inositol Hexaniacinate
  Vitamin C (Ascorbic Acid)

Preventive measures against Alcohol-related Problems:
DietNot recommended:
  Caffeine/Coffee Avoidance
 A study published in the journal "Archives of Internal Medicine" in 2006 indicates that coffee may greatly reduce the risk of liver damage in those who consume alcohol regularly. Every daily cup of coffee reduced the incidence of cirrhosis, a condition that destroys liver tissue, by 22%, according to researchers at the Kaiser Permanente Medical Care Program. However, Dr. Arthur Klatsky, the leader of the study, said the results "should not be interpreted as giving a license to drink without worry, because of all the other problems connected with drinking." adding, "the only proper advice is to drink less."


KEY
Weak or unproven link
Strong or generally accepted link
Proven definite or direct link
Very strongly or absolutely counter-indicative
May do some good
Likely to help
Highly recommended
Reasonably likely to cause problems


GLOSSARY

Acetylcholine
A neurotransmitter widely distributed in body tissues with a primary function of mediating synaptic activity of the nervous system and skeletal muscles.

Allergy (Allergies)
Hypersensitivity caused by exposure to a particular antigen (allergen), resulting in an increased reactivity to that antigen on subsequent exposure, sometimes with harmful immunologic consequences.

Aneurysm
Localized enlargement of an artery.

Antidepressant (Antidepressants)
Literally, substances meant to oppose depressions or sadness, and generally heterocyclic types such as Elavil, MAO inhibitors like phenelzine, or lithium carbonate. This category of substances formerly included stuff like amphetamines and other stimulants. Botanical examples include Hypericum, Peganum and Oplopanax.

Anxiety
Apprehension of danger, or dread, accompanied by nervous restlessness, tension, increased heart rate, and shortness of breath unrelated to a clearly identifiable stimulus.

Bacteria (Bacterial, Bacterium)
Microscopic germs. Some bacteria are "harmful" and can cause disease, while other "friendly" bacteria protect the body from harmful invading organisms.

Cancer
Refers to the various types of malignant neoplasms that contain cells growing out of control and invading adjacent tissues, which may metastasize to distant tissues.

Candidiasis (Candida)
Infection of the skin or mucous membrane with any species of candida, usually Candida albicans. The infection is usually localized to the skin, nails, mouth, vagina, bronchi, or lungs, but may invade the bloodstream. It is a common inhabitant of the GI tract, only becoming a problem when it multiplies excessively and invades local tissues. Growth is encouraged by a weakened immune system, as in AIDS, or with the prolonged administration of antibiotics. Vaginal symptoms include itching in the genital area, pain when urinating, and a thick odorless vaginal discharge. Candidiasis is also known as: Candida; Candida albicans; Candida Related Complex; Chronic Candida Syndrome; (Chronic) Systemic Candidiasis; Monilia; Candidiasis Hypersensitivity Syndrome; Candidosis; (Chronic) Mucocutaneous Candidosis; Thrush (oral or vaginal); Moniliasis; Polysystematic Candidiasis.

Carbohydrates (Carbohydrate)
The sugars and starches in food. Sugars are called simple carbohydrates and found in such foods as fruit and table sugar. Complex carbohydrates are composed of large numbers of sugar molecules joined together, and are found in grains, legumes, and vegetables like potatoes, squash, and corn.

Cardiovascular
Pertaining to the heart and blood vessels.

Cholesterol
A waxy, fat-like substance manufactured in the liver and found in all tissues, it facilitates the transport and absorption of fatty acids. In foods, only animal products contain cholesterol. An excess of cholesterol in the bloodstream can contribute to the development of atherosclerosis.

Chronic (Chronicity)
Usually referring to chronic illness: Illness extending over a long period of time.

Cirrhosis (Liver Cirrhosis)
A long-term disease in which the liver becomes covered with fiber-like tissue. This causes the liver tissue to break down and become filled with fat. All functions of the liver then decrease, including the production of glucose, processing drugs and alcohol, and vitamin absorption. Stomach and bowel function, and the making of hormones are also affected.

Crave (Craving, Cravings)
To have a strong desire for; to feel the need for.

Cup (Cups)
A unit of volume measurement equal to 8 fluid oz, or roughly 250ml. It also equals 1/2 pint, 1/4 quart and 1/16 gallon.

DCM
Dilated Congestive Cardiomyopathy, the most common type of cardiomyopathy.

Dementia (Senile Dementia)
An acquired progressive impairment of intellectual function. Marked compromise exists in at least three of the following mental activity spheres: memory, language, personality, visuospatial skills, and cognition (i.e. abstraction and calculation).

Edema
Abnormal accumulation of fluids within tissues resulting in swelling.

Enzymes (Enzyme)
Specific protein catalysts produced by the cells that are crucial in chemical reactions and in building up or synthesizing most compounds in the body. Each enzyme performs a specific function without itself being consumed. For example, the digestive enzyme amylase acts on carbohydrates in foods to break them down.

Esophagus (Esophageal)
Commonly called the "food pipe", it is a narrow muscular tube, about nine and a half inches long, that begins below the tongue and ends at the stomach. It consists of an outer layer of fibrous tissue, a middle layer containing smoother muscle, and an inner membrane, which contains numerous tiny glands. It has muscular sphincters at both its upper and lower ends. The upper sphincter relaxes to allow passage of swallowed food that is then propelled down the esophagus into the stomach by the wave-like peristaltic contractions of the esophageal muscles. There is no protective mucosal layer, so problems can arise when digestive acids reflux into the esophagus from the stomach.

Fatty Acids (Fatty Acid)
Chemical chains of carbon, hydrogen, and oxygen atoms that are part of a fat (lipid) and are the major component of triglycerides. Depending on the number and arrangement of these atoms, fatty acids are classified as either saturated, polyunsaturated, or monounsaturated. They are nutritional substances found in nature which include cholesterol, prostaglandins, and stearic, palmitic, linoleic, linolenic, eicosapentanoic (EPA), and decohexanoic acids. Important nutritional lipids include lecithin, choline, gamma-linoleic acid, and inositol.

Folic Acid
A B-complex vitamin that functions along with vitamin B-12 and vitamin C in the utilization of proteins. It has an essential role in the formation of heme (the iron containing protein in hemoglobin necessary for the formation of red blood cells) and DNA. Folic acid is essential during pregnancy to prevent neural tubular defects in the developing fetus.

Gram (gm, gms, Gramme, Grammes, Grams)
A metric unit of weight, there being approximately 28 grams in one ounce.

Hemochromatosis
A rare disease in which iron deposits build up throughout the body. Enlarged liver, skin discoloration, diabetes mellitus, and heart failure may occur.

Hepatotoxic (Hepatotoxicity)
Being toxic or destructive to the liver.

High-Density Lipoprotein (HDL)
Also known as "good" cholesterol, HDLs are large, dense, protein-fat particles that circulate in the blood picking up already used and unused cholesterol and taking them back to the liver as part of a recycling process. Higher levels of HDLs are associated with a lower risk of cardiovascular disease because the cholesterol is cleared more readily from the blood.

Iron
An essential mineral. Prevents anemia: as a constituent of hemoglobin, transports oxygen throughout the body. Virtually all of the oxygen used by cells in the life process are brought to the cells by the hemoglobin of red blood cells. Iron is a small but most vital, component of the hemoglobin in 20,000 billion red blood cells, of which 115 million are formed every minute. Heme iron (from meat) is absorbed 10 times more readily than the ferrous or ferric form.

IU (mIU, uIU)
International Unit: An arbitrarily defined but agreed upon unit that depends on what is being measured.
mIU: 0.001 or one thousandth of an IU.
uIU: 0.000001 or one millionth of an IU.

Larynx (Laryngeal, Voice Box)
The short passageway shaped like a triangle that is just below the pharyx in the neck.

Liver (Hepatic)
The largest and one of the most complex organs of the body, the liver is responsible for much of the metabolism of fats, proteins and carbohydrates. It is the site of much of the body's detoxification. It is connected very closely with digestion and the regulation of blood sugar, among many other functions. Found behind the ribs on the right side of the abdomen, it has many important functions such as removing harmful material from the blood, making enzymes and bile that help digest food, and converting food into substances needed for life and growth. Hepatic: Pertaining to the liver.

Magnesium
An essential mineral. The chief function of magnesium is to activate certain enzymes, especially those related to carbohydrate metabolism. Another role is to maintain the electrical potential across nerve and muscle membranes. It is essential for proper heartbeat and nerve transmission. Magnesium controls many cellular functions. It is involved in protein formation, DNA production and function and in the storage and release of energy in ATP. Magnesium is closely related to calcium and phosphorus in body function. The average adult body contains approximately one ounce of magnesium. It is the fifth mineral in abundance within the body--behind calcium, phosphorus, potassium and sodium. Although about 70 percent of the body's magnesium is contained in the teeth and bones, its most important functions are carried out by the remainder which is present in the cells of the soft tissues and in the fluid surrounding those cells.

Metabolism (Metabolic, Metabolize, Metabolizes, Metabolizing)
The chemical processes of living cells in which energy is produced in order to replace and repair tissues and maintain a healthy body. Responsible for the production of energy, biosynthesis of important substances, and degradation of various compounds. Also defined as the sum total of changes in an organism in order to achieve a balance (homeostasis): Catabolic burns up, anabolic stores and builds up; the sum of their work is metabolism.

Milligram (mg, Milligrams)
0.001 or a thousandth of a gram.

Multiple Sclerosis (MS)
Demyelinating disorder of the central nervous system, causing patches of sclerosis (plaques) in the brain and spinal cord, manifested by loss of normal neurological functions, e.g. muscle weakness, loss of vision, and mood alterations.

Neurotransmitters (Neurotransmitter)
Chemicals in the brain that aid in the transmission of nerve impulses. Various Neurotransmitters are responsible for different functions including controlling mood and muscle movement and inhibiting or causing the sensation of pain.

Niacin (B3, B-3, Niacinamide, Vitamin B3)
A coenzyme B-complex vitamin that assists in the breakdown of carbohydrates, fats and proteins. Essential for the health of the skin, nerves, tongue and digestive system. It is found in every cell of the body and is necessary for energy production. Niacin is also needed for DNA formation.

Over-The-Counter (OTC, Over The Counter)
A drug or medication that can legally be bought without a doctor's prescription being required.

Pneumonia (Pneumonitis)
Inflammation, usually infectious, of the lungs. Unless the result of only moderate chemical or smoke irritation, it is a potentially life-threatening condition. There are so many defenses against an infection this deep in the body that the very presence of pneumonia signals a pathogen of great virulence or impaired or exhausted immunity, or all three. Pneumonitis: Inflammation of the lungs, from whatever cause. It may be concurrent with pneumonia or pleurisy.

Polyunsaturated
Polyunsaturated fats or oils. Originate from vegetables and are liquid at room temperature. These oils are a good source of the unsaturated fatty acids. They include flaxseed with added vitamin B6 (pyridoxine), sunflower oil, safflower oil, and primrose oil.

Postpartum Depression
The "baby blues" are a very frequent and completely normal consequence of childbirth, usually wearing off soon afterwards as hormonal and psychological systems get back to normal. Postpartum depression is a less common but severe depression that begins in the weeks following delivery. It impairs the ability of the mother to care for the child and fall in love with it. This makes her feel even more depressed and inadequate thinking that she can not be a good mother. At the extreme, postpartum depression may lead to dangerous delusions (for example, thinking the baby is in some way deformed or cursed) or hallucinations (that may command violent acts). This can occasionally result in a tragic episode of suicide and/or infanticide.

Protein (Proteins)
Compounds composed of hydrogen, oxygen, and nitrogen present in the body and in foods that form complex combinations of amino acids. Protein is essential for life and is used for growth and repair. Foods that supply the body with protein include animal products, grains, legumes, and vegetables. Proteins from animal sources contain the essential amino acids. Proteins are changed to amino acids in the body.

Pyridoxine
A B-complex vitamin that plays a role as a coenzyme in the breakdown and utilization of carbohydrates, fats and proteins. It facilitates the release of glycogen for energy from the liver and muscles. It also participates in the utilization of energy in the brain and nervous tissue and is essential for the regulation of the central nervous system.

Pyroluria
This condition is caused by an overproduction during hemoglobin synthesis of kryptopyrrole, which chemically combines with vitamin B6 and zinc, resulting in their excretion and a severe deficiency of both of these essential nutrients. Most pyroluric individuals never develop
schizophrenia symptoms.

Rhinophyma
A condition of the skin that can severely deform the nose.

Stomach
A hollow, muscular, J-shaped pouch located in the upper part of the abdomen to the left of the midline. The upper end (fundus) is large and dome-shaped; the area just below the fundus is called the body of the stomach. The fundus and the body are often referred to as the cardiac portion of the stomach. The lower (pyloric) portion curves downward and to the right and includes the antrum and the pylorus. The function of the stomach is to begin digestion by physically breaking down food received from the esophagus. The tissues of the stomach wall are composed of three types of muscle fibers: circular, longitudinal and oblique. These fibers create structural elasticity and contractibility, both of which are needed for digestion. The stomach mucosa contains cells which secrete hydrochloric acid and this in turn activates the other gastric enzymes pepsin and rennin. To protect itself from being destroyed by its own enzymes, the stomach’s mucous lining must constantly regenerate itself.

Syndrome
A medical condition characterized by a collection of related symptoms (what the patient feels) and signs (what a doctor can observe or measure).

Thiamine (B1, B-1, Thiamin, Vitamin B1)
A B-complex vitamin that acts as a coenzyme necessary for the conversion of carbohydrates into glucose, which is burned in the body for energy. It is essential for the functioning of the nervous system.

Tryptophan
Essential amino acid. Natural relaxant and sleep aid due to its precursor role in serotonin (a neurotransmitter) synthesis. Along with tyrosine, it is used in the treatment of addictions.

Vitamin B6 (B6, B-6)
Influences many body functions including regulating blood glucose levels, manufacturing hemoglobin and aiding the utilization of protein, carbohydrates and fats. It also aids in the function of the nervous system.

Vitamin C (Ascorbic Acid)
A water-soluble antioxidant vitamin essential to the body's health. When bound to other nutrients, for example calcium, it would be referred to as "calcium ascorbate". As an antioxidant, it inhibits the formation of nitrosamines (a suspected carcinogen). Vitamin C is important for maintenance of bones, teeth, collagen and blood vessels (capillaries), enhances iron absorption and red blood cell formation, helps in the utilization of carbohydrates and synthesis of fats and proteins, aids in fighting bacterial infections, and interacts with other nutrients. It is present in citrus fruits, tomatoes, berries, potatoes and fresh, green leafy vegetables.

Vitamin E
An essential fat-soluble vitamin. As an antioxidant, helps protect cell membranes, lipoproteins, fats and vitamin A from destructive oxidation. It helps protect red blood cells and is important for the proper function of nerves and muscles. For Vitamin E only, 1mg translates to 1 IU.

Wernicke-Korsakoff
Wernicke-Korsakoff syndrome stems from causes similar to those of beriberi, depletion of the body's stores of thiamine (vitamin B1) from many years of malnutrition due to alcoholism. Symptoms include anemia, anxiety, depression, and confusion. About 40 percent of those affected also have anemia as a result of folic acid deficiency.

Zinc
An essential trace mineral. The functions of zinc are enzymatic. There are over 70 metalloenzymes known to require zinc for their functions. The main biochemicals in which zinc has been found to be necessary include: enzymes and enzymatic function, protein synthesis and carbohydrate metabolism. Zinc is a constituent of insulin and male reproductive fluid. Zinc is necessary for the proper metabolism of alcohol, to get rid of the lactic acid that builds up in working muscles and to transfer it to the lungs. Zinc is involved in the health of the immune system, assists vitamin A utilization and is involved in the formation of bone and teeth.




Last updated: Apr 13, 2008


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